ID H2UEG5_TAKRU Unreviewed; 2190 AA.
AC H2UEG5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSTRUP00000035334.3};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSTRUP00000035334.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035334.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035334.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035334.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 31033.ENSTRUP00000076985; -.
DR Ensembl; ENSTRUT00000035462.3; ENSTRUP00000035334.3; ENSTRUG00000022459.2.
DR GeneTree; ENSGT00940000157469; -.
DR HOGENOM; CLU_024323_1_0_1; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 173..282
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 676..853
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1688..2149
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1277..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2162..2190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2190 AA; 248608 MW; BBDCEF2CF7FCDCD8 CRC64;
MSFRSKITFR RKTKGKRVRS LFNHLNIQEK PKAIDPLDYE AVISKLGDEL KEDPLRELLL
FPDNDFLVSA VPQESRTLKL TVPEGAELQA ECLLVREACK YYNSELNVLQ FKYDDYAGDY
RLLPRKLPKA EKLPSHSFEI DYEDVDKDED TTSLSSSKGG GGGGGGGGGG GIGVFRSGWL
YKGNFNSTVN NSITVRSFKR RYFQLTQLPD NSYIMNFYRD EKISKEPKGC IFLDSCTGVV
QNNRLRKHAF ELKMNEVTYF VLAAESEQDM EDWISTLTRI LQISPNDGPA PDRKSLDLTD
HRQDVFDLSL GDSCLQENED TVTENGINPE LAKYIAETDE RIRSARREER LNLFSLDPDT
PVLRSPRAEH SSVENGGVRP FEEKLGRRFM VTCRSLNLTL QGCISESETG PVTNIEPFFV
SLALLDVREG RKVSADFHVD LNHEAVRQML GEVNNGTAGP GTGVGAQENG LCSPAERKPG
DCYLSMDMEH WLCFPKQAIF SVTNPHTDIV MVARVEKVLM GNIACGTEPY IKNSDSSKTV
QKIVKSNKHF CSKLGKYRMP FAWSVRSVFR DNHGALDRES RFSPLFKQES NKISVDDLMK
LVSEYRRAEK TSKLQTIPGT LDIAVDYVPM EHPNCVTSSY IPVRPFEDLS KHQPTVEVEE
FVQDSTKFTL PHRVYRNHIY VYPKHLKYDS QKSFAKARNL TVYVEFRSSD DEVAKPLKCI
YGKPGGSVFT TAACSTVLHH SQNPDFYDEV KIELPTQLHD KHHLLFSFYH VTCDINAKTN
AKRKESLETP VGFSWLPLFK EGRLSSQEFS IPVSCNLPPG YLAIKEASNT KNGADVKWVD
GGKAIFKVST NVVSTVYTQD PHLNRFFQQC QKRELDLSLP PTSNFLNCLK GLLSMERIPV
IIRFLPVLFN QLFKVLTQND NDEVTTATTR VLVHIVAKCH EENLDHYLHS YIKYVFKAEA
HGFRTVHEEL AKGMTFDLKS NEHSAVRNVL KFSWFFFELI VKSMAQHLVE SDKVKLPRPQ
RFPSSYLSRV ETLVETVSEH IFWKNKDLAE ETRSANLAVA AFVKRCFSLL DRGFTFKLIS
NYINMITATD SKILCELKFE FLREVCNHEH YIPLSLPLPS ARITDHASPE PQSTHALVPE
YSLTGEFCRK HFLTGLLLRE LGLALQDEQD LRHLALSTLK TLMAKHSLDA RYATKEKQAR
IASLYLPLYG LILDNMPRFF LRDLFPIYFT SSDQGSRDDL SVGGGVTSVT RHGNSVDASF
SKEVLNSITA FSSLAVPSGN QTDSRGSLIS VDSNPSNSDR NSEKMDGCEK FARPQSLIGY
GSRCDKLDQA ETRSLLMCFL HIMKTISEDV LVSYWHRAIH QEISDFFSIL ELCLQHFRFL
GKRHIARKLA AAVKLAQSTQ ANGTLKGSNH PSQSSQPSSL FPQWMAPSGG DGHRHARSQT
MPIIRGKNAL TNPKLLQMME TDGTIQEVDS LSPTDIEANL STEVALTVLD VLELFVHHHK
KQLQLDEGQN SLLKKVLDTY LLFFQINQST TTLRHVFAAL RLFVQKFPSA FFQGKADLCG
CLCYEILKCC NHRSSSTQTE ASALLYFFMR TNFEFTKGKS IVRSHLQVIK AVSQLIADAG
IGGSRFQQSL AIINNFANGD APLKNTPFPA EVKDLTKRIR TVLMATAQMK EHEKDPEMLV
DLQYSLANSY ASTPELRRTW LESMAKVHVR NGDLSEAAMC YIHISALIAE SLKRRGYWRA
DKTRMSSVSP EESPVFNCSS LLTTSRDQDT SFCMGWAAFM CISPNVKEEG AMKEDTGTQD
TPYTEDTLVE QLKLCVDYLW KSERYELIAD INKPVIAVFE KRRDFKRLSE LYYDIHRSYL
KVTEVVNSEK RLFGRYYRVA FYGQGFFEEE ESKEFIYKEP KLTGLSEISQ RLLKLYSDKF
GADNVKMIQD SNKVNPKDLD PKFAYIQVTY VVPYFDEKEQ QEKMTDFEGH HNINRFVFET
PFTLSGKKHG DVEEQCKRRT ILTTSSSFPY LKKRIQVVEQ QSTEMNPIEV AIDEMSRKVS
ELNQLCNMEE VDMIRLQLKL QGSVSVKVNA GPMAYARAFL EEKNAKKYPD NQVKLLKEIF
RQFAEACGQA LNVNERLIKE DQLEYQEEMR AHYRDMLTEL SGVMNEQLHT SLVAASSSSL
SNSSLSTLSK TDPSHKTARN GATQRLLNGQ
//
