ID H2UF05_TAKRU Unreviewed; 846 AA.
AC H2UF05;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Prospero homeobox 1 {ECO:0000313|Ensembl:ENSTRUP00000035524.3};
GN Name=prox1 {ECO:0000313|Ensembl:ENSTRUP00000035524.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035524.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035524.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035524.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_003971723.2; XM_003971674.2.
DR AlphaFoldDB; H2UF05; -.
DR STRING; 31033.ENSTRUP00000050090; -.
DR Ensembl; ENSTRUT00000035652.3; ENSTRUP00000035524.3; ENSTRUG00000013890.3.
DR eggNOG; KOG3779; Eukaryota.
DR GeneTree; ENSGT00940000154790; -.
DR HOGENOM; CLU_016051_0_0_1; -.
DR TreeFam; TF316638; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR PANTHER; PTHR12198:SF10; PROSPERO HOMEOBOX 1A; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 668..826
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
FT REGION 129..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 297..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 93406 MW; 7778F423ED527831 CRC64;
MPDHDSDSFL NRQTKRRRVD IGVKRTVGST ASSTVAAVTA TTDNIARAKA AIFSAMNSLS
SHSHHGSDTD SMECSVVQPH GGPGVVSASD NESKSNVLRK LLKRANSYED AMMPFPGTTI
ISQLLKNNMA KNGGGHDRGE RGDRGDRGDA GFPGSGLSNA SPDAPQEDAC SNSSQDSTPP
ECMSPFGRPH GLATFDIERL NDEHMRAKRA RVENIIRGMS HSPSVVIPAA SRHERNHEID
GERETELDCP PPQSQQQPPS SPRGGEVCGG SSRENKRKQR LPQQQQQSFT QLVCQRKEQK
QEERRQLKLQ LEDMQKQLRQ LQEKFFQIYD STDDSEHNDL HNDLHNDIGN MSEDSPSRSD
AAADDRGGDD LRSDNEMSDL DPGHFLDRAR ALLQEQALLA DGEKPRREGI SRSKAPGGLS
SSMHAEGKQL AETLKQELNS AMTQVVDTVV KVFAKPPRPP PQQAFHPLSI PPERFPTVNG
DNPNFHTTNP RLQCFGDVII PNPLDSFANM PGMPGATNDQ TEALPLVVRK TPSEHHQSSA
VGAQGGHHHP ALHPSSLSAS MGFSPPSFRH PFPLPLMGYP FQSPLGAPTG GYPGKEHSSP
DSMDLSRETT SLRTKMTSGH HLGHHHRSCS PAHPGSTAEG LSLSLIKSEC GDLQDMSDIS
PYPGSNIQEG LSPNHLKKAK LMFFYTRYPS SNMLKMFFSD VKFNRCITSQ LIKWFSNFRE
FYYIQMEKFA RQAINDGVTG SEELSVSRDC ELFRALNMHY NKANDFEVPD RFLEVAEVTL
REFFNAIVAG KDVDPSWKKA IYKVICKLDS EVPEVFKSPN CLQELLHDVS QIGGRSSILH
NLGWVP
//
