ID H2UF73_TAKRU Unreviewed; 1412 AA.
AC H2UF73;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Adhesion G protein-coupled receptor L1 {ECO:0000313|Ensembl:ENSTRUP00000035592.3};
GN Name=ADGRL1 {ECO:0000313|Ensembl:ENSTRUP00000035592.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035592.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035592.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035592.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 31033.ENSTRUP00000082451; -.
DR Ensembl; ENSTRUT00000035720.3; ENSTRUP00000035592.3; ENSTRUG00000013918.3.
DR GeneTree; ENSGT00940000159684; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd16007; 7tmB2_Latrophilin-1; 1.
DR CDD; cd22844; Gal_Rha_Lectin_LPHN1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR031234; Latrophilin-1_TM.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF62; ADHESION G PROTEIN-COUPLED RECEPTOR L1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 821..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..101
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 111..370
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 444..501
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 823..1064
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 389..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 112..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1412 AA; 158467 MW; 0613D44BC7A647E8 CRC64;
MMPFGLMRRE LACEGYPIEL RCPGSDVIMV ETANYGRTDD KICDADPFQM ENVQCYLPDA
FKIMSQRCNN RTQCVVVAGS DVFPDPCPGT YKYLEIQYEC VPYSEYQQFF VCPGKLLRVQ
AASSLQEAEH QAGAWCKDPL QSGDRLYVMP WTPYRTDMLY EYASWEDFKQ SRATTSYKLP
NRVDGTGFVV YDGAVFYNKE RTRNIVKYDL RTRIKSGEAI ITNANYHDTS PYRWGGKSDI
DLAVDENGLW VIYATEANNG RLVVSQVNPY TLRFEGTWET SFDKRMASNA FMACGVLYAV
RSVYQDDDSE AGGDLVLYAY NTNHGQEEPV HIAFPNPYQY ISSVDYNPRD NQLYVWNNYN
VLRYELEFGP PDPTTGPQTT TQVTTTLPAR PFTSSASPTT ARPLASTSRP VGSINKHPDL
RPITATVPVT RRPHYPPHSL EPYFCETKLV RGVQWPTTQR GDTVERPCPK GSLGIASFRC
LAEQVMWNPR GPDLSNCTSP WVNQVAQKIK SGENAANIAT ELVNHTQSRI QAGDVSSSVR
LIEQLLDILD AQLQSLRPGS KESVPRNYNN YNKRRERTCR AYIQAVVQTV NNLLRPEALE
SWKDMNSTEQ AHTATMLLDV LEEGAFLLAN NMYGTRFSDS AANIDLEVHV LNTELDQQDL
SFPQNSSSES TIQLSASTIK QYSRNGQVKV VFVLYKNLGS FLSTENATVK MEVEGPMSEK
RHLAVNSHII AASINKESSR VFLTEPVVFT LKHLQLDNYH TPNCSFWNYS ERSMTGQWSS
LGCRLLHTNS THTTCSCSHL TNFAVLMALH EPDYQGRMHE LILFVITWVG IVISLVCLAI
CISTFCFLRG LQTDRNTIHK NLCINLFVAE LLFLIGIDKT DNQIACPIFA GLLHFFFLAA
FSWMCLEGVQ LYLMLVEVFE SEYSRKKYYY LCGYCFPALV VGISAAIDYR SYGTKKACWL
RVDNYFIWSF IGPVSFVIML NLIFLMVTLH KMICNSSALK PDSSRLDNIK SWSLGAITLL
FLLGLTWAFG LLFINENTVI MAYLFTIFNA FQGMFIFIFH CALQKKVHKE YSKCLRHSYC
CSRTSTSSSH GSLKNSGLRT NNRYYSSSQT RHSRIRRMWN DTVRKQTESS FMAGDINNTP
TLNRATMGNH LLTNPVLQTR GGTSPYNTLL AESFTPPSPG VFNSTGYKCN SLHARDPCGM
ETLPLNGNFN NSYSLRSGPA GETLAGGTRR NIPDAAAFEK MIISELVHNN LRGGVVGGGG
GGGGGDVGGR PHAQRTPQDV ELLYKALEEP LLLQRAQSVL YQSDPEDSES YTVDLTETPD
SPARDSLYTS ITNLRDSPYP DSSPEPLEVV PRSAQPPEEL YYSSGRPALG SRGAPMQTFY
QAQLQRPSGE VHQPQEPAHS EGDGQMQLVT SL
//
