ID H2UFD3_TAKRU Unreviewed; 603 AA.
AC H2UFD3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Vacuolar fusion protein MON1 homolog {ECO:0000256|RuleBase:RU367048};
GN Name=MON1B {ECO:0000313|Ensembl:ENSTRUP00000035653.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035653.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035653.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035653.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in membrane trafficking through the
CC secretory apparatus. {ECO:0000256|RuleBase:RU367048}.
CC -!- SIMILARITY: Belongs to the MON1/SAND family.
CC {ECO:0000256|ARBA:ARBA00008968, ECO:0000256|RuleBase:RU367048}.
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DR AlphaFoldDB; H2UFD3; -.
DR STRING; 31033.ENSTRUP00000035653; -.
DR Ensembl; ENSTRUT00000035781.3; ENSTRUP00000035653.3; ENSTRUG00000013942.3.
DR eggNOG; KOG0997; Eukaryota.
DR GeneTree; ENSGT00390000006665; -.
DR InParanoid; H2UFD3; -.
DR OMA; LEPTDLH; -.
DR OrthoDB; 73361at2759; -.
DR TreeFam; TF314665; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR004353; Mon1.
DR PANTHER; PTHR13027; SAND PROTEIN-RELATED; 1.
DR PANTHER; PTHR13027:SF13; VACUOLAR FUSION PROTEIN MON1 HOMOLOG B; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
DR PRINTS; PR01546; YEAST73DUF.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 166..288
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 327..428
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 457..563
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 67640 MW; 06CBCD0375E8D6D5 CRC64;
MDRDNQQADE AEGGKICDPP ADTLATSLSL LGNHMFPERN YIPSMKNEEH NDSLYETTED
QSEEAQADDV TKPETEKAEC FECQESVSSP PADRGLEDAT CPADSDHADS GEFVVTMLAK
AKLEEQGLGV EGQSSPLLEA GAQDSPGFAS HRDEDVTADS WRQHRKHVFV LSEAGKPIYS
RYGSEEALSS TMGVMMALVS FVQSGDNIIR SFYSEEHTVV FLHKEPLVLV CVSSSRQSER
QLRGELLYVY YQIISMLTQA SISRIFEHKK NYDLRRLLAG SEKILDGLLN LLDSDPSFLL
AAVHCLPLAS SLRDSLSQIL QKAITPNLVF SILIARNQLL TIVQEKTVIE DTRLEPADVL
LLLNLIGASS AFQAGEIWTP ICLPLFNPDC YFYAYISYLD PPECTVCLLL LSTDKEAFYA
VAECKRKIEG AMVAQNSLSL IAKVQPYSVS QVGVSDLRHF MYKPFDVPDN HRQLTQFTSP
EMEAPYSSEE EQLRLLDLYR YMHSRIHSTS RPLKLIYHVA ERETLLAWVT SKFELYSCFS
PLVTKACAIT AITKLLRWIK KEEDRLFIRY PPKYSTTPNP SKSSRAGKSD QQDSTDNGFL
SLL
//
