ID H2UHI8_TAKRU Unreviewed; 303 AA.
AC H2UHI8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=SEC22 homolog A, vesicle trafficking protein {ECO:0000313|Ensembl:ENSTRUP00000036409.1};
GN Name=sec22a {ECO:0000313|Ensembl:ENSTRUP00000036409.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036409.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000036409.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000036409.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000256|ARBA:ARBA00003595}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003962201.1; XM_003962152.2.
DR AlphaFoldDB; H2UHI8; -.
DR STRING; 31033.ENSTRUP00000036409; -.
DR Ensembl; ENSTRUT00000036540.3; ENSTRUP00000036409.1; ENSTRUG00000014240.3.
DR GeneID; 101069654; -.
DR KEGG; tru:101069654; -.
DR CTD; 26984; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000158470; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; H2UHI8; -.
DR OMA; NTGMQEC; -.
DR OrthoDB; 129635at2759; -.
DR TreeFam; TF105933; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; LONGIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46258:SF3; VESICLE-TRAFFICKING PROTEIN SEC22A; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000259|PROSITE:PS50859"
SQ SEQUENCE 303 AA; 34269 MW; A3C1C67A0560F5D2 CRC64;
MSMVLFASVV RVEDGLPLSA STDYEQDKEL LETKKHLKGL SKKLGQFPDR CTLKAGSYNV
NFTSSLGVGY LMVCTSNYPN VLAFCFLDEL QREFIVTYDR KRISSALRPY SFIEFDTFIQ
KTKQRYNSPR SLSTKINLAD MQMEIKLRPP YQLSPEDLRA VNGYSAHVPS KYKGLAPSLM
LEPVSLPGVV SCVLSVLCGG LNLLRGVHAI ESVLQNEEED FNYVIAFFLG TAACLYQCYL
FAYFAVWRSS KSVLAFALVC LSNMYLYELR NVWQILFHVA VGAFMTLQIR LRQPLGKAPD
YNV
//
