ID H2UHS3_TAKRU Unreviewed; 868 AA.
AC H2UHS3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSTRUP00000036494.3};
GN Name=LOC101074459 {ECO:0000313|Ensembl:ENSTRUP00000036494.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036494.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000036494.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000036494.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2UHS3; -.
DR Ensembl; ENSTRUT00000036625.3; ENSTRUP00000036494.3; ENSTRUG00000004327.3.
DR GeneTree; ENSGT00940000162782; -.
DR OMA; MWLLLQT; -.
DR OrthoDB; 4098716at2759; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF418; C-FAMILY ODORANT RECEPTOR OLFCQ19-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..868
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025346067"
FT TRANSMEM 599..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 600..865
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 868 AA; 96400 MW; 67401E00FEF96004 CRC64;
MADITGTLGL FFTLITLFVS SSTSFNAPIC KLWRKFQFNE MHEPGDVLLG GLFQVHYGSV
FPEWTFTSEP HQPVCTGFDI LGFRHAMTMA FAVQEINKNP DLLPNLTLGY RLYDNCGALV
VGFSGALALA SGQEEAFALQ GGCAGSPPVL GIVGDSLSTF TIASASVLGL YKIPMVSFFA
TCSCLTNRQR FPSFFRTIPS DAFQVRAMIQ ILKHFGWTWV GLLVSDDDYG LHVARSFQSD
LAQSGQGCLA YLEVLPWDGD LSENRRIVHV IKESTARVLM MFAHEFHMIH LMDEVVRQKV
TGLQWLASEA MTAAAVLQTP DIMPYLNGML GIAIRRGEIT GLRDFLLRIR PGQISNNTSY
NMVQQFWEYS FQCKFGASGS AEACTGDENI QQVDAEFLDV SNLRPEYNIY KAVYALAYAL
DDMLQCEPGR GPFSGGNCAD IHKLEPWQFV HYLQHVNFTT TFGDQVSFDE NGDVLPIYDI
VNWQWLPNGR TQVQNVGEVK RSPSRGEELQ IHEDKIFWNF ESNKPPQSVC SESCPPGTRM
SRKKGQPVCC FDCLPCSEGE ISNTTDSMEC TSCPEDFWSS PQRDHCVPKK TEFLSYHEPL
GICLTAASLL GTVISAVVLG IFIHHRSTPV VRANNSELSF LLLVSLKLCF LCSLLFIGRP
RLWTCQLRHA AFGISFVLCV SCILVKTMVV LAVFRASKPG GGATLKWFGA VQQRGTVLGL
TSVQAAICTT WLVSYSPEPH KNTQYYNYKI VYECVVGSPI GFAVLMGYIG LLAVLSFQLA
FLARNLPDNF NEAKLITFSM LIFCAVWVAF VPAYINSPGK YADAVEVFAI LASSFGLLVA
LFGPKCYIIL LRPERNTKKA IMDRDTRK
//
