GenomeNet

Database: UniProt
Entry: H2UIK8_TAKRU
LinkDB: H2UIK8_TAKRU
Original site: H2UIK8_TAKRU 
ID   H2UIK8_TAKRU            Unreviewed;       636 AA.
AC   H2UIK8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN   Name=LOC101073735 {ECO:0000313|Ensembl:ENSTRUP00000036779.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036779.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036779.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036779.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC       {ECO:0000256|ARBA:ARBA00010107}.
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DR   RefSeq; XP_011601974.1; XM_011603672.1.
DR   AlphaFoldDB; H2UIK8; -.
DR   Ensembl; ENSTRUT00000036910.3; ENSTRUP00000036779.2; ENSTRUG00000014388.3.
DR   GeneID; 101073735; -.
DR   GeneTree; ENSGT00940000157744; -.
DR   OrthoDB; 118560at2759; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 4.10.320.30; -; 1.
DR   Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR002717; HAT_MYST-type.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR040706; Zf-MYST.
DR   InterPro; IPR002515; Znf_C2H2C.
DR   InterPro; IPR036060; Znf_C2H2C_sf.
DR   PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR10615:SF210; HISTONE ACETYLTRANSFERASE KAT7; 1.
DR   Pfam; PF01853; MOZ_SAS; 1.
DR   Pfam; PF01530; zf-C2HC; 1.
DR   Pfam; PF17772; zf-MYST; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF103637; CCHHC domain; 1.
DR   PROSITE; PS51726; MYST_HAT; 1.
DR   PROSITE; PS51802; ZF_CCHHC; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01143}.
FT   DOMAIN          358..632
FT                   /note="MYST-type HAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51726"
FT   REGION          1..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        534
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ   SEQUENCE   636 AA;  72717 MW;  D5D7A28EDAA070B9 CRC64;
     MKMPRRKRTA GSSSDGTEDS DFSTDLEHTE APKGSCTRSS SRLTRASLRL SQNSQDSCNP
     VRSSSPAAVG AEEAHDTVAE ASTAVAESSF SSERMVTRSQ QWAANNKAKK YSLRQSRSSG
     SDTEANDAKQ RPDQDDTPPR TPTGNTLSSE SDMEVCSPSN EVVSSSNNPI VSQEEDERLA
     KELSLKEAAA HDLSHRPKRR RFHESYNFNM KCPTPGCNSL GHLTGRHERH FSISGCPLYH
     NLSVDECKGK NTTRDKPAEE RTLTHRQDEN RHSTRSQAPS DRQLRYKEKV TEIRRKRNSN
     LNKEQKDKCM DHLQNHGVSR EPLLENITSD YDLELFRKAQ ARASDDLEKL RLAGQVSEGS
     NMIKTIVFGR YELDTWYHSP YPEEYARLGR LYMCEFCLKY MKSQTILRRH TAKCVWKHPP
     GDEIYRKGNI SVFEVDGKKN KIYCQNLCLL AKLFLDHKTL YYDVEPFLFY VMTEADNTGC
     HLVGYFSKEK NSFLNYNVSC ILTMPQYMRQ GYGKMLIDFS YLLSKVEEKV GSPERPLSDL
     GLISYRSYWK EVLLRYLCNF QGKDISIKEI SQETAVNPVD IVSTLQSLQM LKYWKGKHLI
     LKRQDLIDDW KAKETKRGHG KTIDPTALKW TPPKGT
//
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