UniProt: H2ULB2

Database: UniProt
Entry: H2ULB2_TAKRU

LinkDB:  H2ULB2_TAKRU 
Original site:  H2ULB2_TAKRU

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Ontology (6)   
   GO (6)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (15)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (3)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (25)   

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ID   H2ULB2_TAKRU            Unreviewed;      1969 AA.
AC   H2ULB2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Myosin heavy chain, fast skeletal muscle {ECO:0000313|Ensembl:ENSTRUP00000037733.3};
GN   Name=myhm86-1 {ECO:0000313|Ensembl:ENSTRUP00000037733.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000037733.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000037733.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000037733.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC       ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   Ensembl; ENSTRUT00000037869.3; ENSTRUP00000037733.3; ENSTRUG00000015032.3.
DR   eggNOG; KOG0161; Eukaryota.
DR   GeneTree; ENSGT00940000162888; -.
DR   InParanoid; H2ULB2; -.
DR   OMA; LWQYRIL; -.
DR   TreeFam; TF314375; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd01377; MYSc_class_II; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.340; -; 5.
DR   Gene3D; 1.20.5.370; -; 5.
DR   Gene3D; 1.20.5.4820; -; 1.
DR   Gene3D; 1.20.58.530; -; 1.
DR   Gene3D; 6.10.250.2420; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR004009; Myosin_N.
DR   InterPro; IPR008989; Myosin_S1_N.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR   PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF02736; Myosin_N; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 6.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51844; SH3_LIKE; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          33..82
FT                   /note="Myosin N-terminal SH3-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51844"
FT   DOMAIN          86..783
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   REGION          660..682
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   REGION          1585..1604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1690..1928
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         179..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ   SEQUENCE   1969 AA;  225212 MW;  0E977021785D917E CRC64;
     MSTDAEMEQY GPASIYLRKP ERERIEAQNT PFDAKTAYFV AEPAEMYLKG KLIKREGGKA
     TVETVTGKTI TVKEDDIHAM NPPKFDKIED MAMMTHLNEP SVLYNLKERF ASWMIYTYSG
     LFCVVVNPYK WLPVYDAQVV NAYRGKKRIE APPHIFSISD NAYQFMLTDR ENQSVLITGE
     SGAGKTVNTK RVIQYFATIA VAGGGKKAEQ GSGKIQGSLE DQIIAANPLL EAYGNAKTVR
     NDNSSRFGKF IRIHFGSSGK LASADIETYL LEKSRVTFQL SAERSYHIFY QLMTGHKPEL
     LEALLITTNP YDYPMISQGE ITVKSINDVE EFIATDTAIE ILGFTAEEKI AIYKLTGAVM
     HHGNMKFKQK QREEQAEPDG TEEADKIAYL MGLNSADMLK CLCYPRVKVG NEMVTKGQTV
     PQVNNAVSAL CKSVYEKMFL WMVIRINEML DTKQSRSFFI GVLDIAGFEI FDFNSLEQLC
     INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE
     CMFPKATDTS FKNKLHDQHL GKTKAFEKPK PAKGKAEAHF SLVHYAGTVD YNINGWLDKN
     KDPLNDSVVQ LYQKSSNKLL SMLYAAHAGA DDAAAGGGKK GGKKKGGSFQ TVSALFRENL
     GKLMTNLRST HPHFVRCLIP NETKTPGLME NFLVIHQLRC NGVLEGIRIC RKGFPSRILY
     GDFKQRYKVL NASVIPEGQF IDNKKASEKL LGSIDVDHTQ YKFGHTKVFF KAGLLGTLEE
     MRDEKLAELV TMTQALCRGF LMRKEFVKMM ERRDAIFTIQ YNVRSFMNVK NWPWMHLYFK
     IKPLLKSAET EKELAQMKEN YGKMQTDLAT ALAKKKELEE KMVSLLQEKN DLQLQVASES
     ENLSDAEERC EGLIKSKIQL EAKLKETTER LEDEEEINAE LTAKKRKLED ECSELKKDID
     DLELTLAKVE KEKHATENKV KNLTEEMASQ DESIAKLTKE KKALQESHQQ TLDDLQAEED
     KVNTLTKAKT KLEQQVDDLE GSLEQEKKLR MDLERAKRKL EGDLKLAQES IMDLENDKQQ
     SDEKLKKKDF EISQLLSKIE DEQSLGAQLQ KKIKELQARI EELEEEIEAE RAARAKVEKQ
     RADLSRELEE ISERLEEAGG ATAAQIEMNK KREAEFQKLR RDLEESTLQH EATAAALRKK
     QADSVAELGE QIDNLQRVKQ KLEKEKSEFK MEIDDLSSNM EAVAKAKANL EKMCRTLEDQ
     LSEIKSKNDE NVRQLNDLSA QKARLQTENG EFSRQIEEKE ALISQLTRGK QAYTQQIDEL
     KRHIEEEVKA KNALAHAVQS ARHDCDLLRE QYEEEQEAKA ELQRAMSKAN SEVAQWRTKY
     ETDAIQRTEE LEEAKKKLAQ RLQDAEESIE AVNSKCASLE KTKQRLQGEV EDLMIDVERA
     NSLAANLDKK QRNFDKVLAE WKQKYEEGQA ELEGAQKEAR SLSTELFKMK NSYEEALDHL
     ETLKRENKNL QQEISDLTEQ IGENGKSIHE LEKAKKAVES EKAEIQTALE EAEGTLEHEE
     SKILRVQLEL NQIKGEVDRK LAEKDEEMEQ IKRNSQRVID SMQSTLDAEV RSRNDALRVK
     KKMEGDLNEM EIQLSHANRQ AAEAQKQLRN VQGQLKDAQL HLDDAVRGQE DMKEQVAMVE
     RRNGLMMAEI EELRAALEQT ERGRKVAEQE LVDASERVGL LHSQNTSLLN TKKKLEADLV
     QVQGEVDDSV QEARNAEEKA KKAITDAAMM AEELKKEQDT SAHLERMKKN LEVTVKDLQH
     RLDEAENLAM KGGKKQLQKL ESRVRELEAE VEAEQRRGVD AVKGVRKYER RVKELTYQTE
     EDKKNVNRLQ DLVDKLQLKV KAYKRQAEEA EEQANTHMSR LRKVQHEMEE AQERADIAES
     QVNKLRAKSR DVGKVLCAII HCLNIPNINS GIYNNFTIIT IRFHFLFLH
//

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