ID H2UNJ8_TAKRU Unreviewed; 893 AA.
AC H2UNJ8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=DEAD/H-box helicase 11 {ECO:0000313|Ensembl:ENSTRUP00000038519.3};
GN Name=ddx11 {ECO:0000313|Ensembl:ENSTRUP00000038519.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038519.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000038519.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000038519.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR AlphaFoldDB; H2UNJ8; -.
DR Ensembl; ENSTRUT00000038658.3; ENSTRUP00000038519.3; ENSTRUG00000015074.3.
DR eggNOG; KOG1133; Eukaryota.
DR GeneTree; ENSGT00950000182970; -.
DR InParanoid; H2UNJ8; -.
DR OMA; QTHQFRD; -.
DR TreeFam; TF300435; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:1990700; P:nucleolar chromatin organization; IEA:Ensembl.
DR GO; GO:1901836; P:regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0009303; P:rRNA transcription; IEA:Ensembl.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 4..423
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100283 MW; 4D70F1BC1127F01D CRC64;
MDIGRTQFPF PYQPYDIQQQ FMQALYSALD QGKVGIFESP TGTGKSLSLI CGALSWLTDF
EEKRRQETAA LLQKGEVSLS SAAPSSSTSS SAEPDWITDF VQKKAERDLV SKLKDDELKR
QKREERLEMI RGNAQLKYAM KRKSSEDDEA FQLLQLSKDD RTEERGDEGD EELVIAEYQS
DDESKTRSRY CADEDDAGDE LVEEHITKIY YCSRTHSQLA QFVHEVQKSP FANDISLVTL
GSRQNLCINE EVRRLGSIQH INDRCMEMQK NKHEKQHQED GAKRKRGPAK STCPYNKAPA
LQRMRDEILG AVQDIEQLLK LGSETRSCPY YSTRLTIPPA QLVVLPYQML LHEATRRAAG
VQLKGQVVII DEAHNLSDTL SCIYSAELTG AQLCRAHSQL TQYTHRFKSR LKAKNLMYIK
QILFVIEGLI RVLGGKVGQN PQSQTTKAGT EMLTINNLLF KAEIDNINLF KLQKYFQKSL
ISRKLGGFVE KYAGTGMTLH PQSCSNKENR RTQGLNHYLQ TLQSNRTAPV SAADQQGSLE
AEKALAASPM MQVEGFFMAL TSSNTDGRVV VNNQETLSES SVKFLLLNPA VHFAQILKEC
RAVVIAGGTM QPVSDFKQEL LFSAGVGEER IVEFSCGHVI PPENILPLVL CNGPSGQELD
FTFQNRDSPH MMDETGRILS NICNVVPGGV VCFFPSYEYL RRITSHWETN GTLARLANKK
KIFHEPKKSN LVEQVLKDFS RCIQRCAADS GALTGALLFS VVGGKMSEGI NFSDDLGRCV
VMVGMPYPNI KSPELQEKMS YLDKHLPHNG GKSPGQALIE NLCMKAVNQS IGRAIRHRGD
YSSMVLCDRR YSRPATLAKL PAWIRDRTST HTSFGPAFAT LRKFFHERKR KQV
//
