ID H2UNP5_TAKRU Unreviewed; 716 AA.
AC H2UNP5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=T-box transcription factor 3 {ECO:0000313|Ensembl:ENSTRUP00000038566.3};
GN Name=tbx3 {ECO:0000313|Ensembl:ENSTRUP00000038566.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038566.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000038566.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000038566.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; H2UNP5; -.
DR STRING; 31033.ENSTRUP00000038566; -.
DR Ensembl; ENSTRUT00000038705.3; ENSTRUP00000038566.3; ENSTRUG00000015097.3.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158066; -.
DR HOGENOM; CLU_023038_1_0_1; -.
DR InParanoid; H2UNP5; -.
DR OMA; QGIAMSP; -.
DR OrthoDB; 5323209at2759; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000005226; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF91; T-BOX TRANSCRIPTION FACTOR TBX3; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 108..291
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 307..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 77783 MW; E705497EA30371BF CRC64;
MNFLMRDPVI QGSSMAYHPF IPHRGPELAM SAMLGHQPPF FPALALPHTG SLSLPGALGK
PIMDQLMGAA ETGLHFSSLG HQAAAAHLRP LKTLEPEEEV EDDPKVHLEA KELWELFHKK
GTEMVITKSG RRMFPPFKVR CTGLDKKAKY ILLMDIVAAD DCRYKFHNSR WMVAGKADPE
MPKRMYIHPD SPATGEQWMS KVVNFHKLKL TNNISDKHGF VSSTNTILNS MHKYQPRFHI
VRANDILKLP YSTFRTYVFP ETDFIAVTAY QNDKITQLKI DHNPFAKGFR DTGNGRREKR
KQLALQSMRS YEEQQKKENG ASDDSSGEQA PFKCFGQASS PAVSTVGPPH LKDYCDSDED
SDDESKDGHL KDGPDSSKIS TTTEDGKDHE ASPAKAHSFP KSDAASRNRD SGPRTEKSQA
DSRQSPITVI SSTTRSGEDL KSPSLDQPKS DECRPISKDS FMPLTVQTDS PHIGHGHLHN
FGFPTGLTGQ QFFNHLGSAH PFLLHPSQFN VGGAFSNMAA GMGPLLAAVS TGGVSTMDTA
SMTSPPQSLT GAPGLPFHLQ QHVLASQGIA MSPFGGLFPY PYTYMAAAAA ASSAASSSVH
RHPFLNAVRP RLRYSPYSLP MTAPDSTLLT TAMPPSMTVG GTELKGDGLV PASPVSAVTL
DSTSEVTSHS STISSGSVSM SPKTLTEKDA ANELQSIQRL VSGLESNQDR SRSGSP
//
