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Database: UniProt
Entry: H2UPV9_TAKRU
LinkDB: H2UPV9_TAKRU
Original site: H2UPV9_TAKRU 
ID   H2UPV9_TAKRU            Unreviewed;      4904 AA.
AC   H2UPV9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000038980};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038980, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000038980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000038980}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   STRING; 31033.ENSTRUP00000038980; -.
DR   Ensembl; ENSTRUT00000039120; ENSTRUP00000038980; ENSTRUG00000015260.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155288; -.
DR   OMA; TKHILKM; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005226; Chromosome 11.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR   GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4208   4228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4432   4450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4513   4535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4650   4671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4709   4729       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4789   4811       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      207    261       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      266    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      331    388       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      571    784       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1193       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1325   1538       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      452    472       {ECO:0000256|SAM:Coils}.
FT   COILED     1859   1889       {ECO:0000256|SAM:Coils}.
FT   COILED     2819   2839       {ECO:0000256|SAM:Coils}.
FT   COILED     3554   3581       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4904 AA;  557221 MW;  F806E9A0A77D7407 CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE GGGHRTLLYG HAILLRHNHS GMYLSCLTTS
     RSLTDKLAFD VGLQEDSTEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS SERYLHLSYA
     SGDLMVDASF MQTLWNMNPI SSGCELAEFL TGGHVLRLFH GHMDECLAIA TPEEGEEKRM
     AHYEGGSVCS QARSLWRLEP LRIWSGSHMK WGQSFRIRHI TTGRYLCLDE EKGLLVVDPE
     RANTKLSAFC FRASKEKVDV AQKRDVEGMG IPEIKYGESM CFVQHVSTGL WLTYASLDAK
     AARLGMMKRK VILHQEGHMD DALTVSRSQT EESQAARMIY STVGLFRQFI GLDTLTGKNK
     SPGALSLPLE GVILSLQDLI FYFRPPDEEL EHEEKQTKLR SLRNRQNLFQ EEGMITIVLE
     CIDRLNVYNT AAHFSEFAGE EAAESWKEIV NLLYELLSLI RGNRSNCALF CDNLDWLVSK
     LDRLEASSIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKQVL DVLRSLCVCN
     GVAVRSNQNL ITENLLPGRD LLLQTNIVNY VTPNIFLGTC EGSTQYKKWY YEVMVDHVEA
     FVTAQATHLR VGWAMTEGYS PYPGGGEGWG GNGVGDDLYS YSFDGLHLWS GTVPRQVASP
     NAHTLAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNV DSLFFPVISF SAGVARFLLG
     GRHGDFKFMP PPGYAPCYEA LLPRERMRIE PIKEYKHDFN GVRNLLGPTL SLTHTSFTPC
     PVDTVQIVLP PHLERIREKL AENIHELWAV TRIEQGWTYG SFRDDNKKLH PCLVDFQSLP
     EPERNYNLQM SAETLTLLAL GCHVGMGDEK AEENLKKIKL PKYVMSNAYK PAPLDLSHVK
     LTPNQNQLVE KLAENGHNVW ARDRVRQGWT YSIVQQDILN KRNPRLVPYI LLDERTKKTN
     RDSVNNAVRT LIGYGYNIEP PDQESGHGLE NTRGDKVRIF RAEKSYAVTQ GKWYFEFEAV
     TTGEMRVGWA RPNVHSDTEL GADELAYVFN GNKAQRWHIG NEPFGRQWQS GDVVGCMIDL
     TEMNIMFTLN GEMLISDSGS EMAFKDIEIG EFIPVCTLGL SQVGRINLGQ NVSSLRYFAI
     CGLQEGFEPF AINMKRDTTM WFSKSLPQFV PVPADHNHIE VSRVDGTVDS APCLKLTHKT
     YGSQNANTDM LFLRLSMPIQ FHATFKVPAG TTPLTRALTI PEDVAVVEPD SEFEVLKKSA
     SRKEQEEDKK EPSVPKEILA ENEKDTMSEK GKKRFFSKAK KAAMTPLAPP PPPTVPRLVE
     DVVPDDRDDP EIILSTTTYY YSVRIFAGQE PSGVWVGWVT PDYHQYDQTF DLSKVRSVTV
     TVGDDKGNIY NSMKHSNCYM VWGDDLVSNH QTRFSQEDMV IGCLVDLATG LMTFTANGKE
     INTFYQFQVE PNTKLFPAVF VQPLSQNMVQ LELGKLKNIM PISAAMFRSE RNNPVPQCPP
     RLDVQMLTPV IWSRMPNRFL NPDVGRVSER LGWVVECTEP LIMMALHIPE ENCIDILELS
     ERQDLMKFHY HTLMLYCAVC ALGNNRVAHA LCSHVDESQL FYATENTYLP GPLRSGYYDL
     LISIHLESAK RARLGTNREF IVPMTEETLS IKLYPDAVKA HSLPGVGLTT CLRPKLHFSS
     INFVGTDLDL YTLSPVFPLQ ELKNRAISML TEAVLDGSQA MRDPVGGSVE FHFVPILKLI
     STLLIMGIFN DDDTKHILKM IDPNVFSGKD DEEETDKPVE GGPAEGEGDK AKGEESEEAA
     ELEDEGVGEE EEEDELKNLK GDDTEEEAEP KEEGEEEEKE EGEAKTGKVD GEKMEEEKEA
     EVVAVDLKDE EEGLEEGLLQ MKLPESVKLQ MCTLLQFFCD CELRHRVEAI VAYSDKFVHN
     IQDNQRIRYN QLMRAFTMSA AETARKTREF RSPPQDQVLL LTNFKHSLEE EECPVPDNVR
     ETLKEFHNDL LLHCIHIEEE PVEEEVDTSL RGRLLSLVDK IKSIRGKKTE EKPEVEEETK
     PTLQELISHT MIHWAQESFI QNPELVRLMF SLLHRQYDGL GELIRALPKA YAINAVSVQD
     TMDLLECLGQ IRSLLIVQMG PEEERLMIQS INIMNNKVFY QHPNLMRALG MHETVMEVMV
     NVLGGGGDSK EIRFPQMVTN CCRFLCYFCR ISRQNQRSMF DHLSYLLQNS SIGLMRGSTP
     LDVAAASCID NNELALALQE QDLEMVVTYL AGCGLQMCPM LLSKCYPDIG WNPCGGERYL
     DFLRFAVFVN LIQAGKGEAL RIRAILRSLV PIEDLVGVIS LPVQIPSYGK SQIVEPKMSA
     SFVPDHKASM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTVAFS TTEMALALNR
     YLCSAVLPLL TKCAPLFAGT DHRAIMIDSM LHTIYRLSRG RALTKAQRDV IEECLMSLCY
     LRPSMLQHLL RRLVFDVPIL NEYAKMPLKL LTNHYERCWK YYCLPNGWAN FGVTSEEELH
     LSRKLFWGIF ESLAHKKFDA ELFKIAMPCL CAIAGAIPPD YVDASYSSHT EKKASVDAEG
     NFDPKPVETT TIIPERLDAF INKYAEHTHD KWAFEKIQNN WTYGEVLDED AKTHPMLRPY
     KTFSEKDKEI YRWPIKESIK AMLAWEWTLE KARDGEGEVE KKAATRKISQ TAQATYDPSH
     GYSPQPIDIS GMTLSRELQS MAEQLAENYH NTWGRKKKVE LQSKGGTHPL LVPYDTLTAK
     EKARDREKAQ DLLKFLQLNG YAVTGMKDME QDISSIEKRF AYGFLQKLLK WMDIAQEFIA
     HLAVVSSGRV EKSPHEQEIK FFAKILLPLV NQYFKNHCLY FLSTPAKVLG SGGHSSNKEK
     EMIAIFCKLA ALVRHRVSLF TDASAVVNCL HILSRSLDAT VMKSGPEIVK AGLRQFFESA
     ADDIEKMVEN LKLGKVSSRN QVKGVSQNIN YTTIALLPVL TSLFDHIAQH QFGDDVIVDD
     LQISCYRIMC SIYSLGTVKT PHAEQRPALG ECLAHLAAAM PVAFLEPTLN EFNTFSVYTT
     KTPRERSLGL PSQVEELCPD IPELEVLMKD IHDLAESGAR YTEMPHVIEI TLPMLCNYLP
     RWWERGLENF PEQEGQICTS VTSEQLNQLL GSIMKIVVNN LGIDEASWMK RLAFAQPIVS
     RAKPEMLKSH FIPTMEKLKK RCGKVVAEED HLRMEGKTEV DSENGTIRDE FAVLCRDLYA
     LYPLLIRYVD NSARWLTNPD PDAEELFRMV GEVFIFWSKS HNFKREEQNF VVMNEINNMS
     FLTADSKSKM SKSLSGGSEQ ERTKKKRRGD RYSVQTSLIV AALKKLLPIG LNMCSPADQE
     LINLAKIRYS LKDTDEEVRE FLHNNLHLQG KVEDPAMRWQ MSLYKEMAGK AEDAEDPEKV
     VKRVQEVSAV LYHIEQTEHP FKSKKMVWHK LLSKQRRRAV VACFRMTPLY NIIHRATNMF
     LDAYKRNWLE TEGYSFEDKM IDDLSKAMEE EEEEEEETER KPDPLHQLIL HFSRTALTEK
     KLDVDHLYMS YADIMAKSCH IGEEDEGGEQ EGEEPSFEVR QTEMEKEMEK QRLLYQQSRL
     HNRGAAEMVL QMISAEPGAM VSSTLKLGIS ILNGGNSDVQ QKMLDYLKDK KDVGFFLSIQ
     SLMQTCSVLD LNAFERQNKA EGLGMVSEEG TEKVMADDEF TCDLFRFLQL LCEGHNNFQN
     YLRTQTGSTT TINVIICTVD YLLRLQESIS DFYWYYSGKD IIDEPGKRNF SKAMNVAKQV
     FNSLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMMM KLAQDSSQIG LLKELLDLQK
     DMVVMLLSLL ENVVNGTIAK QMVDMLVESS SNVEMILKFF DMFLKLKDIV ASDAFRDYVT
     DPRGLISKKD FSKAMDSQKQ YTPAEIQFLL SCSEADENEM INFEEFADRF QEPAKDIGFN
     IAVLLTNLSE HVPHDTRLQN FLEQAESVLN YFRPFLGRIE IMGASRKIER IYFEISEANR
     NQWEMPQVRE SKRQFIFDVV NEGGESEKME MFVNFCEDTI FEMNIAASIS EPEGEAAEEE
     DDEEEEEGGG QEGEPAEGEE GNGEEHAPES TSAFADFLKS VVNFFNMFTF RNLRRRYRRF
     RKMTVKEMVI GLATFVYTVV MGILMFVYSI CKGFFTLIWK VLFGGGLVES AKKMTVTDIL
     ASMPDPTQDE VHGELPPEPG SREDQDTEGG ADLLDPVGGE EEEEDSEERE GGRLPGFNTP
     GGLGDFGETT PEEPPTPEGT PLLKRKLEEE NAEHEEPPQE TEKATENGEK AKKPEAEPEV
     KEEEPVEEEE ITVKAKAKKS KKPVEEGFEL WNELEIQRVK FMNYLSRNFY NLRYLALFIA
     FALNFILLFY KVSDSPPGEE DFEGSGLFEG SGLFEGSGVQ EDGSGLDDGG EDDDEEGPLY
     YFLEESTGYM EPAMAFLSIV HTIISFLCII GYNCLKVPLV IFKREKELAR KLEFDGVYVT
     EQPEDDDIKG QWDRLVLNTS FPNNYWDKFV KRKVLDKYGD IYGRERIAEL LGMDLASLDV
     SAMTHEKKPE PDTSMFSITS IDIKYQIWKF GVVFTDNTFL YLVWYFLMSI LGHYNNFFFA
     AHLLDIAMGV KTLRTILSSV THNGKQLMMT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED
     EPDMKCDDMM TQCYLFHMYV GVRAGGGIGD EIEDPAGDEY ELYRVVFDIT FFFFVIVILL
     AIIQLIIDAF GELRDQQEQV REDMECFICG IGSDYFDTTP HGFETHTLEE HNLANYFFLM
     YLINKDETEH TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLG
//
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