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Database: UniProt
Entry: H2UPW6_TAKRU
LinkDB: H2UPW6_TAKRU
Original site: H2UPW6_TAKRU 
ID   H2UPW6_TAKRU            Unreviewed;      4973 AA.
AC   H2UPW6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 38.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000038987};
GN   Name=LOC101073831 {ECO:0000313|Ensembl:ENSTRUP00000038987};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038987, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000038987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000038987}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSTRUT00000039127; ENSTRUP00000038987; ENSTRUG00000015260.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4299   4319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4512   4530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4577   4599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4716   4737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4775   4795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4854   4877       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      227    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    351       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      353    410       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    814       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1033   1229       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1352   1569       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      477    497       {ECO:0000256|SAM:Coils}.
FT   COILED     2890   2910       {ECO:0000256|SAM:Coils}.
FT   COILED     3644   3671       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4973 AA;  564446 MW;  9AEF18C9ABDD24E9 CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE AVDLDKWWHF IVHSSQGGGH RTLLYGHAIL
     LRHNHSGMYL SCLTTSRSLT DKLAFDVGLQ EDSTGEACWW TIHPASKQRS EGEKVRVGDD
     LILVSVSSER YLHLSYASGD LMVDASFMQT LWNMNPISSG CELAEGTSFL TGGHVLRLFH
     GHMDECLAIA TPEEGEEKRR MAHYEGGSVC SQARSLWRLE PLRISWSGSH MKWGQSFRIR
     HITTGRYLCL DEEKGLLVVD PERANTKLSA FCFRASKEKV DVAQKRDVEG MGIPEIKYGE
     SMCFVQHVST GLWLTYASLD AKAARLGMMK RKVILHQEGH MDDALTVSRS QTEESQAARM
     IYSTVGLFRQ FIKFRGLDTL TGKNKSPGAL SLPLEGVILS LQDLIFYFRP PDEELEHEEK
     QTKLRSLRNR QNLFQEEGMI TIVLECIDRL NVYNTAAHFS EFAGEEAAES WKEIVNLLYE
     LLASLIRGNR SNCALFCDNL DWLVSKLDRL EASSGILEVL YCVLIESPEV LNIIQENHIK
     SIISLLDKHG RNHKVLDVLR SLCVCNGVAV RSNQNLITEN LLPGRDLLLQ TNIVNYVTSV
     RPNIFLGTCE GSTQYKKWYY EVMVDHVEAF VTAQATHLRV GWAMTEGYSP YPGGGEGWGG
     NGVGDDLYSY SFDGLHLWSG TVPRQVASPN AHTLAADDVV SCCLDLSVPS ISFRINGHPV
     QGMFENFNVD SLFFPVISFS AGVKARFLLG GRHGDFKFMP PPGYAPCYEA LLPRERMRIE
     PIKEYKHDFN GVRNLLGPTL SLTHTSFTPC PVDTVQIVLP PHLERIREKL AENIHELWAV
     TRIEQGWTYG SPSKFRDDNK KLHPCLVDFQ SLPEPERNYN LQMSAETLKT LLALGCHVGM
     GDEKAEENLK KIKLPKTYVM SNAYKPAPLD LSHVKLTPNQ NQLVEKLAEN GHNVWARDRV
     RQGWTYSIVQ DILNKRNPRL VPYILLDERT KKTNRDSVNN AVRTLIGYGY NIEPPDQEST
     GHGLENTRGD KVRIFRAEKS YAVTQGKWYF EFEAVTTGEM RVGWARPNVH SDTELGADEL
     AYVFNGNKAQ RWHIGNEPFG RQWQSGDVVG CMIDLTEMNI MFTLNGEMLI SDSGSEMAFK
     DIEIGEGFIP VCTLGLSQVG RINLGQNVSS LRYFAICGLQ EGFEPFAINM KRDTTMWFSK
     SLPQFVPVPA DHNHIEVSRV DGTVDSAPCL KLTHKTYGSQ NANTDMLFLR LSMPIQFHAT
     FKVPAGTTPL TRALTIPEDV AVVEPDSEFE VLKKSASRKE QEEDKKEPSV PKEILAENEK
     DTMSEKGKKR GAKKAAMTPL APPPPPTVPR LVEDVVPDDR DDPEIILSTT TYYYSVRIFA
     GQEPSGVWVG WVTPDYHQYD QTFDLSKVRS VTVTVGDDKG NIYNSMKHSN CYMVWGDDLV
     SNHQTRFSQE DMVIGCLVDL ATGLMTFTAN GKEINTFYQV EPNTKLFPAV FVQPLSQNMV
     QLELGKLKNI MPISAAMFRS ERNNPVPQCP PRLDVQMLTP VIWSRMPNRF LNPDVGRVSE
     RLGWVVECTE PLIMMALHIP EENRCIDILE LSERQDLMKF HYHTLMLYCA VCALGNNRVA
     HALCSHVDES QLFYATENTY LPGPLRSGYY DLLISIHLES AKRARLGTNR EFIVPMTEET
     LSIKLYPDAV KAHSLPGVGL TTCLRPKLHF SSINFVGTDL DLYTLSPVFP LQELKNRAIS
     MLTEAVLDGS QAMRDPVGGS VEFHFVPILK LISTLLIMGI FNDDDTKHIL KMIDPNVFSG
     KDDEEETDKP VEGGPAEGEG DKAKGEESEE ADEEEGLEEG LLQMKLPESV KLQMCTLLQF
     FCDCELRHRV EAIVAYSDKF VHNIQDNQRI RYNQLMRAFT MSAAETARKT REFRSPPQDQ
     VLLLTNFKHS LEEEECPVPD NVRETLKEFH NDLLLHCGHV GIHIEEEPVE EEVDTSLRGR
     LLSLVDKIKS IRGKKTEEKP EVEEETKPST LQELISHTMI HWAQESFIQN PELVRLMFSL
     LHRQYDGLGE LIRALPKAYA INAVSVQDTM DLLECLGQIR SLLIVQMGPE EERLMIQSIG
     NIMNNKVFYQ HPNLMRALGM HETVMEVMVN VLGGGGDSKE IRFPQMVTNC CRFLCYFCRI
     SRQNQRSMFD HLSYLLQNSS IGLGMRGSTP LDVAAASCID NNELALALQE QDLEMVVTYL
     AGCGLQMCPM LLSKCYPDIG WNPCGGERYL DFLRFAVFVN GESVEENANV VVRLLIRRPE
     CFGPALRGEG GNGLLAAMEE AIKISEDPAR DGPTVKKAGR FGGEEQQEEN RVHLGNAIMS
     FYSALIDLLG RCAPEMHLIQ AGKGEALRIR AILRSLVPIE DLVGVISLPV QIPSYGKDSQ
     IVEPKMSASF VPDHKASMVL FLDRVYGIDN QDFLLHVLEV GFLPDMRAAA SLDTVAFSTT
     EMALALNRYL CSAVLPLLTK CAPLFAGTDH RAIMIDSMLH TIYRLSRGRA LTKAQRDVIE
     ECLMSLCKYL RPSMLQHLLR RLVFDVPILN EYAKMPLKLL TNHYERCWKY YCLPNGWANF
     GVTSEEELHL SRKLFWGIFE SLAHKKFDAE LFKIAMPCLC AIAGAIPPDY VDASYSSHTE
     KKASVDAEGN FDPKPVETTN TIIPERLDAF INKYAEHTHD KWAFEKIQNN WTYGEVLDED
     AKTHPMLRPY KTFSEKDKEI YRWPIKESIK AMLAWEWTLE KARDGEGEVE KKAATRKISQ
     TAQATYDPSH GYSPQPIDIS GMTLSRELQS MAEQLAENYH NTWGRKKKVE LQSKGGGTHP
     LLVPYDTLTA KEKARDREKA QDLLKFLQLN GYAVTRGMKD MEQDISSIEK RFAYGFLQKL
     LKWMDIAQEF IAHLGNWNFG RVEKSPHEQE IKFFAKILLP LVNQYFKNHC LYFLSTPAKV
     LGSGGHSSNK EKEMIASIFC KLAALVRHRV SLFGTDASAV VNCLHILSRS LDARTVMKSG
     PEIVKAGLRQ FFESAADDIE KMVENLKLGK VSSRNQVKGV SQNINYTTIA LLPVLTSLFD
     HIAQHQFGDD VILDDLQISC YRIMCSIYSL GTVKTPHAEK QRPALGECLA HLAAAMPVAF
     LEPTLNEFNT FSVYTTKTPR ERSILGLPSQ VEELCPDIPE LEVLMKDIHD LAESGARYTE
     MPHVIEITLP MLCNYLPRWW ERGLENFPEQ EGQICTSVTS EQLNQLLGSI MKIVVNNLGI
     DEASWMKRLA VFAQPIVSRA KPEMLKSHFI PTMEKLKKRC GKVVAEEDHL RMEGKTEVDS
     ENGTIRDEFA VLCRDLYALY PLLIRYVDNS RARWLTNPDP DAEELFRMVG EVFIFWSKSH
     NFKREEQNFV VMNEINNMSF LTADSKSKMS KSGGSEQERT KKKRRGDRYS VQTSLIVAAL
     KKLLPIGLNM CSPADQELIN LAKIRYSLKD TDEEVREFLH NNLHLQGKVE DPAMRWQMSL
     YKEMAGKAED AEDPEKVVKR VQEVSAVLYH IEVKSSNRCF KKTFQTEHPF KSKKMVWHKL
     LSKQRRRAVV ACFRMTPLYN IITHRATNMF LDAYKRNWLE TEGYSFEDKM IDDLSKAMEE
     EEEEEEETER KPDPLHQLIL HFSRTALTEK MKLDVDHLYM SYADIMAKSC HIGEEDEGGE
     QEGEEPSFEE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA CKGEPGAMVS STLKLGISIL
     NGGNSDVQQK MLDYLKDKKD VGFFLSIQSL MQTCSVLDLN AFERQNKAEG LGMVSEEGTN
     EKVMADDEFT CDLFRFLQLL CEGHNNDFQN YLRTQTGSTT TINVIICTVD YLLRLQESIS
     DFYWYYSGKD IIDEPGKRNF SKAMNVAKQV FNSLTEYIQG PCTGNQQSLA HSRLWDAVVG
     FLHVFAHMMM KLAQDSSQIG LLKELLDLQK DMVVMLLSLL EGNVVNGTIA KQMVDMLVES
     SSNVEMILKF FDMFLKLKDI VASDAFRDYV TDPRGLISKK DFSKAMDSQK QYTPAEIQFL
     LSCSEADENE MINFEEFADR FQEPAKDIGF NIAVLLTNLS EHVPHDTRLQ NFLEQAESVL
     NYFRPFLGRI EIMGASRKIE RIYFEISEAN RNQWEMPQVR ESKRQFIFDV VNEGGESEKM
     EMFVNFCEDT IFEMNIAASI SEPEGEAAEE EDDEEEEEGG GQEGEPAEGE EGNGEEHAPE
     STSAFADFLK SVVNFFNMFT FRNLRRRYRR FRKMTVKEMV IGLATFVYTV VMGILMFVYS
     ICKGFFTLIW KVLFGGGLVE SAKKMTVTDI LASMPDPTQD EVHGELPPEP GSREDQDTEG
     GADLLDPVGG EEEEEDSEER EGGRLPGFNT PGGLGDFGET TPEEPPTPEG TPLLKRKLET
     EKADTENGEK AKKPEAEPEV KEEEPVEEEE ITVKAKAKKS KKPVEEGFEL WNELEIQRVK
     FMNYLSRNFY NLRYLALFIA FALNFILLFY KFEGSGLFEG SGVQEDGSGL DDGGEDDDEE
     GPLYYFLEES TGYMEPAMAF LSIVHTIISF LCIIGYNCLK VPLVIFKREK ELARKLEFDG
     VYVTEQPEDD DIKGQWDRLV LNTPSFPNNY WDKFVKRKVL DKYGDIYGRE RIAELLGMDL
     ASLDVSAMTH EKKPEPDTSM FSWITSIDIK YQIWKFGVVF TDNTFLYLVW YFLMSILGHY
     NNFFFAAHLL DIAMGVKTLR TILSSVTHNG KQLMMTVGLL AVVVYLYTVV AFNFFRKFYN
     KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDEYELYRV VFDITFFFFV
     IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG SDYFDTTPHG FETHTLEEHN
     LANYMFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
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