ID H2UQ31_TAKRU Unreviewed; 386 AA.
AC H2UQ31;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=VPS37A subunit of ESCRT-I {ECO:0000313|Ensembl:ENSTRUP00000039052.3};
GN Name=vps37a {ECO:0000313|Ensembl:ENSTRUP00000039052.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000039052.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000039052.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000039052.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR AlphaFoldDB; H2UQ31; -.
DR Ensembl; ENSTRUT00000039193.3; ENSTRUP00000039052.3; ENSTRUG00000015286.3.
DR GeneTree; ENSGT00950000183012; -.
DR OrthoDB; 3677578at2759; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 297..386
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 43272 MW; D59B091FFF1CFEE4 CRC64;
MNWLFPLSKG SGPPPLNSLQ QQRQRQIESL KVAHPSLAEI QKDVEYRIPF TVNNSTISVN
ILLPPQFPQE KPVVSVYPPV GHHLVDSNNG TMISSPLVSN FGMHSDLGKV IQSLLDEFWK
SPPVLMSSGL SGFQYLYKSG INPYPTQAFH YGPRHMGPSH AQPTGPAPMT HPVAENAQGP
PRVPAPYGLI SDLPLPVPTG DSQAGLNGHL YKMPEIPESF PELSEMNLMQ LSNLSENEDV
LLELFVSLPQ LKQVTSDKEE LITNIVEMAK KNLQVEPQLE GKRQEMLYKF EQLTQMKSTF
ETRLQRQHEL SESCSLSALQ ARLKVAAHQA EEESEEMAES FLEGRTDIDE FLTSFMEKRT
LCHSRRAKEE KLQQSIITLG QFPTSH
//
