ID H2UTG5_TAKRU Unreviewed; 2282 AA.
AC H2UTG5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 1A {ECO:0000313|Ensembl:ENSTRUP00000040238.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040238.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000040238.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000040238.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 31033.ENSTRUP00000040238; -.
DR Ensembl; ENSTRUT00000040380.3; ENSTRUP00000040238.3; ENSTRUG00000015743.3.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000154658; -.
DR InParanoid; H2UTG5; -.
DR OMA; PFATWSE; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0010874; P:regulation of cholesterol efflux; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF34; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1367..1388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1675..1697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1717..1743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1786..1810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1873..1896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 905..1136
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1932..2164
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1158..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2282 AA; 255996 MW; 101AA26FD192D70B CRC64;
MAVSTQLGLL LWKNFTYRRR QTIQLLIEII WPLFIFFILI SVRTYYPPYE QHECHFPNKA
MPSAGTLPWV QGIICNANNP CFRNPTPGES PGMVGNFNDS IISRLLIDAK KILLYTQNDR
SYEGYSKLLR ALRKMQKNTA HFKLKDFLKD DETLSHFLHR NASLPHHALK QIVEADVNLE
KVLTKGFGFH LRDLCNATPL EEFVHIADRN VSRLTQEIIC KSSSDWLNKA QSHFLSNLDF
FKPIRDVRSD PKVVQEVSAA TNYLLENLGA LAVEVTGTRS WKDMRREIMF LTANATGSPN
QMYQAVSRIV CGHPEGGGLK IKSLNWYEDN NYKALFGNHG NDSDSETRST YDNSSTPYCN
NLMKNMESSP ISRMIWRALK PLLMGKILYT PDTPATQRII HEVNKTFQEL GVLRELGGMW
DEVKPRILNF IENSEEMDLV RTMLQNNASA AFLNSQLSGT EWRVSDISLF LSKAAKDPRR
PGSPYTWRDV FNETDHAIQT ISRFMECVNL DKLEPVANEE RLVNKSMGLL DNQRFWAGIV
FPDIEPSNST ELPAKVNYKI RMDIDNVERT NKIKDSYWDP GPRADPFEDL RYIWGGFSYL
QDIIEHGIIR AVTGTTEKIG VYLQQMPYPC YVDDIFLRVM SRSMPLFMTL AWMYSVAIII
KGVVYEKEAR LKETMRIMGL NNGILWLSWF ISSLIPLLIS AGLLVMLLKM GNLLPYSDPG
VVFLFLGSFG VVTIMQCFLI STLFSRANLA AACGGIIYFT LYLPYVLCVA WQDYVGFGAK
IVVSLLSPVA FGFGCEYFAL FEEQGVGIQW SNLLASPLEE DSYNLTTSIC LMLFDAVLYG
VMTWYIEAVF PGQYGIPRAW YFPFTRTYWC GEKENQNLSS SLSKGNAEGT NLCIEEEPAH
IEPGVYIENL VKVYSNGNKL AVDGLSLKFY NGQITSFLGH NGAGKTTTMS ILTGLFPPTS
GTAYILGKDI RTELSTIRQN LGVCPQHNVL FSMLTVEEHI WFYARLKGLP EEKVKAEMEQ
IVNDVGLPHK RQSRTSTLSG GMQRKLSVAL AFVGGSKVVI LDEPTAGVDP YARRGIWDLL
LKYRQGRTIL LSTHHMDEAD ILGDRIAIIS HGKLCCVGSS LFLKTQLGTG YYLTLVKRDY
DLTLQSCRNS ASTVSYSKKE DSVSESSSDA GLGSEPDSET TTIGKNDSSV HTLGDSFNVS
LISNVIFKHV SEARLVEDLG HELTYVLPYQ SAKDGAFVEL FHELDDRLTD LGISSYGISD
TTLEEIFLKV AEDSGVDSVE LSDGVVPTRT RRRHAFGDHQ SCLKPFTEDD FDFNDSEGDP
DSRETDWLGG TDGKGSYQVK GWSLKRQQFV ALLWKRFLYA RRSRKGFFAQ IVLPAVFVCI
ALVFSLIVPP FGKYPSLVLD PTMYGEQFAF ISNDQPENHH INKLQAALTE KPGFGTRCMD
GGPSLDAPCA PAESDWNVPD VSQSVTELFE RGNWSVENPS PLCECSCGGR KRMLPECPPG
AGGLPPPQMK INDNITLQNL TGRNISDYLV KTYAKIIGKS LKNKIWVNEF RYGGFSLGAR
QSQLMAHADE MDEAIAALRQ RFHLERGTAG DRFFHSLSNF IQGMDTKNIV KIWFNNKGWH
SIGSFLNVMN NGILRANLQA GKDPKTFGIN AYNHPLNLTK EQLSQVALMT TSVDVLVSIC
VIFAMSFVPA SFVVFLIQER VNKAKHMQFI SGVQPFLYWL ANFVWDMCNY IVPATLVIVI
FVCFQQEAYV SSTNLPVLAL LLLLYGWSIT PLMYPASFFF KIPSTAYVVL TSVNILIGIN
GSVSTFVLEL FGSNEIGGIN DILKNVFLIF PHFCLGRGLI DMVKNQAMAD ALERFGENRF
RSPLAWDMVG KNLFAMAIEG VIFFSITVLI QYHFFFKARS STSHLKPIGE EDEDVARERQ
RILSGGGQSD ILELRQLTKI YKRKQKPAVD RLCVGIPRGE CFGLLGVNGA GKTSTFKMLT
GDSMVTGGEA YLASKSVTKE IDEVHQNMGY CPQFDAINDL LTGREHLEFY AILRGVPEKE
VCEVADWGIR KLGLMKYVDK AAGSYSGGNM RKLSTAIALI GGPPVVFLDE PTTGMDPKAR
RALWNAILSI IKEGRSVVLT SHSMEECEAL CTRMAIMVNG RFRCLGSVQH LKNRFGDGYT
IILRVAGPDP DLRPVMGFIE RELPGSTLKE KHRNMLQYQL PTSLTSLARI FSLLSKNKEA
LSIEDYSVSQ TTLDQVFVNF AKDQSDEDHF KEVNLNKRDA VVVDLSQLNP FLTDNSTRES
CV
//
