ID H2UU20_TAKRU Unreviewed; 1538 AA.
AC H2UU20;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Adhesion G protein-coupled receptor B3 {ECO:0000313|Ensembl:ENSTRUP00000040444.3};
GN Name=ADGRB3 {ECO:0000313|Ensembl:ENSTRUP00000040444.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040444.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000040444.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000040444.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 31033.ENSTRUP00000040444; -.
DR Ensembl; ENSTRUT00000040586.3; ENSTRUP00000040444.3; ENSTRUG00000015830.3.
DR GeneTree; ENSGT00940000155081; -.
DR InParanoid; H2UU20; -.
DR Proteomes; UP000005226; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF40; ADHESION G PROTEIN-COUPLED RECEPTOR B3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1538
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025691805"
FT TRANSMEM 877..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 500..570
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 875..1155
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1538 AA; 171705 MW; 36F8B07C06EFAD49 CRC64;
MKAVRNLLIY IFSTYLLVMF GLTGAQDYWC STLVKGVIYG SYSVTEMFPK NYTNCTWTLE
NPDPTKYSIY LKLYKQDLSC SEYSLLAYQF DHYSHEKISE LLKVNESIVY LCDTKNIYVF
LLYDKNFVQL RRVFPYDYNG LTPQKLDEEE KSIVEFLVLN KATPSQFGCQ VLCTWLENCL
KLEKGTVETC GIVYTKCTCP QHLGDGESES MLMLNNVVLP LNPQTEGCLS PQLQGGQICN
LSAEVKRPPK EEYGMIGQHT VKSQRPRSVH DTKALQEQAE SAKFMAQTGE SGAEEWSQWS
SCSVTCGQGS QVRTRTCVSP YGTHCSGPLR ESRVCNNTAP CPVHGVWEEW SPWSLCSFTC
GRGHRTRTRM CAPPQHGGRA CDGPETQTKL CNIALCPVDG QWQEWSSWSD CSVTCANGTQ
QRTRQCSAAA HGGSECRGHW AESRECHNPD CTANGQWNPW GPWSGCSKSC DGGWQRRARV
CQGAAVTGQQ CDGTGEEVRK CSDQRCPAPY EICPEDYAVS MVWRRTPSGE LAFNRCPPNA
TGTTSRRCSL DHRGMAFWEQ PSYARCITNE FRYLQQSVQG HLAKGQRMLA GDGMSQVTKN
LLDLTQRRNF YAGDLLSSVE ILRNVTETFK RASYEPSSDD VQNFFQIISN LLEEENKEKW
DDAQKIYPGA VELMQVIEDF IHIVGLGMKD FHNAYLMTGN LVASIQRLPA VSVMTDINFP
MKGRKGMVDW ARNSEDKVVI PKGLFVSQSA DMEGSPVFIL GTVLYKTLGL MLPSPKNHTV
VNSKVIAVTV RPEPKATESQ LEIELAHNTN GTMGPYCALW DSTIMNDSWG AWSTKGCKTV
LTDASHTKCL CDRVSTFAIL AQQPREITME YSGVPSVTLI VGCGLSCLAL ITLAVIYAVL
WRYIRSERSI ILLNFCLSIV CSNILILVGQ TQTHNAGVCV MTTAFLHFFF LASFCWVLTE
AWQSYMAVTG KVRTRLIRKR FLCLGWGLPA LVVAVSMGFT KTKGYGTPLY CWLSLEGGLL
YAFVGPAAAV VLVNMVIGIL VFNKLVSRDG ILDKKLKHRA GYDSTSLQMS EPHTGLTLKC
AKCGVVSTTA LSATTASNAM ASLWSSCVVL PLLALTWMSA VLAMTDKRSI LFQILFAVFD
SLQGFVIVMV HCILRREVQD AFRCRLRNCQ DPIGGDATGT FPNGHAQIMT DFEKDVDIAC
RSALHKDMGS CRAATITGTL SRISLNDEEE EKAPEGLNYS TLPGNIMSKV IIQQPSALHL
PMGVGDLKEQ CMADGNADMR RTVYLCTDDT MRQSEHDMMG RDMEGHPVAA QMMETDYIVM
PRASAAAVSG SCNTSTLLKD DSKMNITMDT LQHERLMHCK MSPDFSLGPS GMDHMNVNLE
QHYPSAPEQM QNLPFEPRTA VKNFLAEMEE SAGLSRSETG STISMSSLER RKSRYSDLDF
EKVMHTRKRH MELFQELNQK FQTLDRFRDI PNMGTMDKAM PNKNPWESYN PACEYQNYAT
MNVLQSDAKD SLEMTPAEWE KCVNLPLDVQ EGDFQTEV
//
