ID H2UUH6_TAKRU Unreviewed; 210 AA.
AC H2UUH6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Programmed cell death 10 {ECO:0000313|Ensembl:ENSTRUP00000040601.3};
GN Name=pdcd10 {ECO:0000313|Ensembl:ENSTRUP00000040601.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040601.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000040601.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000040601.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the PDCD10 family.
CC {ECO:0000256|ARBA:ARBA00009181}.
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DR AlphaFoldDB; H2UUH6; -.
DR Ensembl; ENSTRUT00000040743.3; ENSTRUP00000040601.3; ENSTRUG00000015882.3.
DR eggNOG; KOG4025; Eukaryota.
DR GeneTree; ENSGT00390000017913; -.
DR HOGENOM; CLU_083906_1_0_1; -.
DR TreeFam; TF105802; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.12.70; -; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 2.
DR InterPro; IPR046409; PDC10_dimerisation_sf.
DR InterPro; IPR009652; PDCD10.
DR InterPro; IPR048288; PDCD10_N.
DR PANTHER; PTHR13250:SF1; PROGRAMMED CELL DEATH PROTEIN 10; 1.
DR PANTHER; PTHR13250; TF-1 CELL APOPTOSIS RELATED PROTEIN-15; 1.
DR Pfam; PF06840; PDC10_C; 1.
DR Pfam; PF20929; PDCD10_N; 1.
PE 3: Inferred from homology;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 13..70
FT /note="Programmed cell death protein 10 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF20929"
SQ SEQUENCE 210 AA; 24230 MW; BA26452EF3617772 CRC64;
MTMEEMKNEA ETNSMVSMTL YAVMYPVFNE LERINLSAAQ TLRAAFIKAE RENPGLTQDI
IMKILEKKNV QINFTESLLR MAADDVEEFM IDRPEQEFQD LNEKARALKH ILSKIPDEIS
DRVRFLQTIK DIASAIKELL DTVNNVIKKY QYQNRRVMSV WRSEGGRRPV CFVHLNSSSS
SVSRAINVFI SANRLIHQTN LILQTFKTVA
//
