ID H2UVH7_TAKRU Unreviewed; 504 AA.
AC H2UVH7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Cytochrome P450 2K1-like {ECO:0000313|Ensembl:ENSTRUP00000040955.2};
GN Name=LOC101064648 {ECO:0000313|Ensembl:ENSTRUP00000040955.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040955.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000040955.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000040955.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR RefSeq; XP_003971492.1; XM_003971443.2.
DR AlphaFoldDB; H2UVH7; -.
DR STRING; 31033.ENSTRUP00000040955; -.
DR Ensembl; ENSTRUT00000041097.3; ENSTRUP00000040955.2; ENSTRUG00000016018.3.
DR GeneID; 101064648; -.
DR KEGG; tru:101064648; -.
DR GeneTree; ENSGT00940000162649; -.
DR InParanoid; H2UVH7; -.
DR OMA; EWTGHAN; -.
DR OrthoDB; 2900138at2759; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF319; CYTOCHROME P450 2K6-RELATED; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01686; EP450ICYP2D.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 504 AA; 57158 MW; 32357720B57EA32E CRC64;
MGIVDLFLQA SSSVSLLGAL ALLLFVYFIS SVSFSSKKDR KCPPGPKPLP ILGNLLQFDL
KRPYNTLMKL SKTYGSVFTV YLGPKKVVVL AGYKTVKEAL IDHAEEFGER DPIMLVQNAN
HEHGVLWSNG ESWKEMRRFA LTNLRDFGMG KKACENKIIE ECSYLMEELK KWKGEPFDTT
HPINYAVSNI ICSMVYGNRF EYDDPEFTSL VDRTNTLIQI SGSPSVLVYD LFPWIGPLVN
NKKLFQSLFA ANKKQNLQLF AAAKEMLNPQ MCRSFVDSFL ARQQILEKSG TNVHFHDENL
MSTVMNLFNA GTDTTATTLR WGLLLMAKYP LIQDQVQEEL RRVIGSRQVQ VEDRKSLPFT
DAVIHETQRL ANIVPMALPH KTSQDVTLQG FFIEKGTTVY PLLTSVLYDE TEWEKPLNFY
PAHFLDKDGK FVKREAFLPF SAGRRICLGE GLAKMELFIF FSTLLQHFRF RPPPGVSEDH
LDLTPRVGLT LNPSAHKLCA VSCL
//
