ID H2UW62_TAKRU Unreviewed; 651 AA.
AC H2UW62;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ankyrin repeat and SOCS box protein 2-like {ECO:0000313|Ensembl:ENSTRUP00000041190.3};
GN Name=ASB2 {ECO:0000313|Ensembl:ENSTRUP00000041190.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041190.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000041190.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000041190.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; H2UW62; -.
DR STRING; 31033.ENSTRUP00000041191; -.
DR Ensembl; ENSTRUT00000041334.3; ENSTRUP00000041190.3; ENSTRUG00000016113.3.
DR GeneTree; ENSGT00940000155490; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT REPEAT 184..216
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 217..249
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 250..282
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 283..315
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 316..348
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 349..381
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 381..413
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 423..451
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 600..646
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 47..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 71356 MW; 16AF9FFDCEB9A993 CRC64;
MAAPSISQSG STAPSLALDD YSLYSHLNDD ELLQLAIERS LKETHNNNAA TTSTPPPHPV
TRTCNQHSSH NPPVDYSSHN PPVGYSSHNP PVDYSSHNPP VDYSSPNPPA ERPPDPEDEP
LFQAIRTGDV NKVRRLVMHS GTKLMLPSKQ GWLAIHQAAW YGQDTCLRVL LSAQPGMINK
KADCGETALM VAVSQEHVPC VQVLLENGAD PDISNREKET PLYKACERNN TAMVAALLNH
GAVVNTRCLL GWTALQEAVC RNNVEVCEML LRAGAKLSLT NIYGISPLFT AAQSGQLAAL
RFLLKHGADI NSQAADGATA LYEATKNEHQ DIVELLISQK ADANKPGKTG LLPLHVASQT
GNEAIVSMLI AVTSKARVRR TGISPLHVAA EYNCDDVLEL LIQAGFDVNA QLSQERSKLY
EDRRSTPLYF SVINGNIEAV EMLLAAGANP NMDMFRPLMV AARQCCVKTV TLLVEHGADV
NACIPTHPTT FPAVYMFSMK YLPMFKYLLD HGGHALCCFE CVYGSGPHPP INITRSESSD
DVPHDRQQRT GVQFCEMISA PSICRWAGPI IDLLLDYVGH VTLCSRLIEH LNSYNAWSVI
KDKAAPPRPL LHLCRLRIEK LVGHKHLKKL PLPGALIRFL KHQHTTSQDE S
//
