ID H2UX47_TAKRU Unreviewed; 450 AA.
AC H2UX47;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=StAR-related lipid transfer protein 3 {ECO:0000256|ARBA:ARBA00020514};
DE AltName: Full=START domain-containing protein 3 {ECO:0000256|ARBA:ARBA00032621};
GN Name=stard3 {ECO:0000313|Ensembl:ENSTRUP00000041526.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041526.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000041526.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000041526.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STARD3 family.
CC {ECO:0000256|ARBA:ARBA00010909}.
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DR RefSeq; XP_003964940.1; XM_003964891.2.
DR AlphaFoldDB; H2UX47; -.
DR Ensembl; ENSTRUT00000041670.3; ENSTRUP00000041526.2; ENSTRUG00000016245.3.
DR GeneID; 101074925; -.
DR KEGG; tru:101074925; -.
DR CTD; 10948; -.
DR GeneTree; ENSGT00940000159051; -.
DR OrthoDB; 3740290at2759; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR CDD; cd08906; START_STARD3-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR019498; MENTAL.
DR InterPro; IPR000799; StAR-like.
DR InterPro; IPR029867; STARD3_MLN64_C.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR Pfam; PF10457; MENTAL; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00978; STARPROTEIN.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR PROSITE; PS51439; MENTAL; 1.
DR PROSITE; PS50848; START; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 51..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..216
FT /note="MENTAL"
FT /evidence="ECO:0000259|PROSITE:PS51439"
FT DOMAIN 242..442
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 450 AA; 50868 MW; 3FD06431145FABDF CRC64;
MPVGEYGVLG GSLPIVTTLN SSYSTSMSLP SPYLFVPPAE RKTISDVRRT FCLFVTFDLL
FISLLWIIEL NISNSIKESL NHEVIHYDYR SSFFDIFLLA VFRFLCLQLG YAAFRLRHWW
VVAVTTLVTS VFLVVKVILS NLLSQNAFGY VLPITSFVVA WLETWFLDFK VLTQEADDER
AYLAAVNAAC ERAPMIYPRA VSDGQFYSPP ESVAGSEEDL DEEGLGRRAV TAQEKEYVSQ
GREAMSVVEQ ILSQEENWKF EKNNDAGDAV YTLEIPFHGK TFILKALMQC PAELVYQEVI
LQPEKMVQWN RTISACQILQ RVDDNTMVSY DVSSGAAGGV VSARDFVNVR RVERKRECYM
SAGMATNHDS KPPCGRFVRG ENGPGGFVVL KSSMNPSVCT FIWVLNTDLK GRLPRYLIHQ
SLAATMFEFM THLRQRIGEL RPALCSHRFP
//