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Database: UniProt
Entry: H2UX47_TAKRU
LinkDB: H2UX47_TAKRU
Original site: H2UX47_TAKRU 
ID   H2UX47_TAKRU            Unreviewed;       450 AA.
AC   H2UX47;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=StAR-related lipid transfer protein 3 {ECO:0000256|ARBA:ARBA00020514};
DE   AltName: Full=START domain-containing protein 3 {ECO:0000256|ARBA:ARBA00032621};
GN   Name=stard3 {ECO:0000313|Ensembl:ENSTRUP00000041526.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041526.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000041526.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000041526.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the STARD3 family.
CC       {ECO:0000256|ARBA:ARBA00010909}.
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DR   RefSeq; XP_003964940.1; XM_003964891.2.
DR   AlphaFoldDB; H2UX47; -.
DR   Ensembl; ENSTRUT00000041670.3; ENSTRUP00000041526.2; ENSTRUG00000016245.3.
DR   GeneID; 101074925; -.
DR   KEGG; tru:101074925; -.
DR   CTD; 10948; -.
DR   GeneTree; ENSGT00940000159051; -.
DR   OrthoDB; 3740290at2759; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   CDD; cd08906; START_STARD3-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR019498; MENTAL.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR029867; STARD3_MLN64_C.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR   PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR   Pfam; PF10457; MENTAL; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF55961; Bet v1-like; 1.
DR   PROSITE; PS51439; MENTAL; 1.
DR   PROSITE; PS50848; START; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        51..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..216
FT                   /note="MENTAL"
FT                   /evidence="ECO:0000259|PROSITE:PS51439"
FT   DOMAIN          242..442
FT                   /note="START"
FT                   /evidence="ECO:0000259|PROSITE:PS50848"
SQ   SEQUENCE   450 AA;  50868 MW;  3FD06431145FABDF CRC64;
     MPVGEYGVLG GSLPIVTTLN SSYSTSMSLP SPYLFVPPAE RKTISDVRRT FCLFVTFDLL
     FISLLWIIEL NISNSIKESL NHEVIHYDYR SSFFDIFLLA VFRFLCLQLG YAAFRLRHWW
     VVAVTTLVTS VFLVVKVILS NLLSQNAFGY VLPITSFVVA WLETWFLDFK VLTQEADDER
     AYLAAVNAAC ERAPMIYPRA VSDGQFYSPP ESVAGSEEDL DEEGLGRRAV TAQEKEYVSQ
     GREAMSVVEQ ILSQEENWKF EKNNDAGDAV YTLEIPFHGK TFILKALMQC PAELVYQEVI
     LQPEKMVQWN RTISACQILQ RVDDNTMVSY DVSSGAAGGV VSARDFVNVR RVERKRECYM
     SAGMATNHDS KPPCGRFVRG ENGPGGFVVL KSSMNPSVCT FIWVLNTDLK GRLPRYLIHQ
     SLAATMFEFM THLRQRIGEL RPALCSHRFP
//
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