ID H2UZC4_TAKRU Unreviewed; 1755 AA.
AC H2UZC4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rho GTPase activating protein 23 {ECO:0000313|Ensembl:ENSTRUP00000042303.3};
GN Name=ARHGAP23 {ECO:0000313|Ensembl:ENSTRUP00000042303.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042303.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042303.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042303.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTRUT00000042447.3; ENSTRUP00000042303.3; ENSTRUG00000016547.3.
DR GeneTree; ENSGT00940000157982; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 82..164
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 838..955
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1047..1238
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 17..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1383
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1542..1574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1755 AA; 193493 MW; B142C983A5C71E2D CRC64;
MNGVAFCLVG IPPYSENHAK GRRDGVSSAP DNPRPPMATR PGREGVSVGW RGPRTLVLHK
NSQGFGFTLR HFIVYPPEST LHANLKDEEN GNEKGYQKSR MEPMDTIFVK SVRERGPAHQ
AGLCTGDRLV KVNGESVLGK TYSQVIALIQ NSESVLELSI MPKDEDVLQL AYSQDAYLTG
NEPYSGGAEN LPPPPPLCYP RSKAAPVSGA PVSAPMGQNQ LDNWSRWPNS SSPSSPLDNC
STVGSPASWQ EGRPGEPGGV GPSSPAHRTE EIQYGMTGKH PQGQTRGRSY SSSSSSGGLL
SSPLQVHYPN HHAASTSQAP PRKSSPAWTS PPLPQLSHSR NERCQQALSD WYHNQIPERP
GRSNQMRHRS YSQDRLSDMR RQQQRAGDWP HSASQDTLLF LQQQQSGPGP RGEPYWSYSD
WDGTAGRGPL APDYTRTRSE NLLAQFDCHG RSLEMLDRAA GPVSPRFERP SWIQQIPQPP
HRTDAYPRQG NHYGAAQAPP ISRHPTHHSQ TPSQPQPPQA ASQRRRLPPG QSMDDQPVGY
RSYSPSFYRK TGRIMQQAHS FRDPSYSGPH LNWNPSPKSP PEGDTAPMTT TVASPLTSTA
PETQNREYRP TNHERDQGSK DEGQEEALVQ TQEVVLRQKP PTGRRNAFGM RHPHYALPAD
GLEPSLFSPE DSAPAPTSKE EGAPRKPNGN LAPLPIEDDS LASIPFIDEP TSPSADLRAR
HVPASSVVSS GMSSAPAMVT SPSSPTFHFP PTRLFSHDCS SIKSSRRSSY LLAITAERSK
SCDEGLNTFR EEGRVFSRLP KRVKSFFTDG SLDNLRSAEE VRSKRHSTSE LGNIAYSDVR
REGWLHYKQI LTEKGKKVGS GMRPWKRVFS VLRSHSLFLY KDKREAVLRG ATIGGGTEDE
QPISIRGCLV DIAYSETKRK HALRLTTQDF CEYLLQAEDR EDMLDWIKVI RENSKTGSEE
LGFSGQALIS KKLNDYRKQS PTGNKPDSSP RLSRMKPPFL LAKTENSTGA PRSPKPEGKD
ESGPLKSPWG INIMKKTKKV VPKAFGVRLE DCQPGVNNKF IPLIVEICCG LVEEMGLEYT
GIYRVPGNNA MVSLLQEQLN KGVDINPAEE KWQDLNVVSS LLKSFFRKLP EPLFTNDKYN
DFIDANRMDD ASERLKTLKK LIRDLPDHYY HTLKFLIGHL KTVADNSDKN KMEPRNLALV
FGPTLVRTSE DNMKEMVTHM PDRYKIVETL IQHGIWFFTD ELDKDEKTPV DTEDVQPAPN
IDHLLPNIGR TGLPGEASDS TNSDSAKSKG SWGSKKDLSP KDFLTLSIMT AVTGRKRRKR
HNAWRVGSST DDDSEHEPVK TGHLGTEEEE EEAECPAGDT APRAEGEEDE EEEEEEEEVV
EGGAKEETEE KVAEVVSGRS QCSEEVKAGG RQPAMLIQEE ARREAKGPLW RAPEDARSIV
SGYSTLSTLG RSLGSEGRGD EADDEHSELV SETDNESGFA SRSLTQERPD KQPRSPPATN
ARPPRSFLYT HVKPPAPSAT SLLAPPPALV HTPDSADRAD GGARSTTPSS SSFSSSSTTH
KLHSRPSFNS HKLIQCDTLA RKKLKSEKAK ARSLDLELSG GGASADGTSS GADSSVTVRR
DSPRTQASSG SSQENPRPAR PSEASSFAPA GPGRSLADQV RARLLGSADD LRSVGLRKPL
SPETRRKRRA WRRHTVVASP TEVSDKRPPL RVNEFPLSPL GQNQFKPAAP LQDPDGVDPG
RAARHTPPSR FHQYL
//
