ID H2UZR3_TAKRU Unreviewed; 935 AA.
AC H2UZR3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO6 {ECO:0000313|Ensembl:ENSTRUP00000042442.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042442.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042442.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042442.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; H2UZR3; -.
DR STRING; 31033.ENSTRUP00000042442; -.
DR Ensembl; ENSTRUT00000042586.3; ENSTRUP00000042442.3; ENSTRUG00000016595.3.
DR GeneTree; ENSGT00940000158969; -.
DR HOGENOM; CLU_006685_1_3_1; -.
DR InParanoid; H2UZR3; -.
DR OMA; SCPNERF; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000005226; Chromosome 18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 319..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 481..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 528..550
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 692..715
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 749..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 847..867
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 82..305
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 308..890
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 935 AA; 109304 MW; 99AB0E0960C445B2 CRC64;
MRRRPETDLI RLFDAPAPGK MNGGDLTETE TEEMEGDVEL AIIHEDVVYP EEFLPTYQTI
NQDAALSRPR LAEFNDKPDS LFFNDGARKI DFILVYEDED KKEFEKRHAY QRRKRRREYF
EASLMKMGLE LEATQSVIDD KLMFVKVHMP WDMLCTYAEV LHIKLPIQPN DLSSRPSPWR
FFDFITKHFY PNEDLIKKEA DYFTAPFEKD RLEFFHIADK DSFFTPSMRS RMAYYLLSRA
PYEIRGSVKK FGISKLLDSG VYKAAYPLHD CQFNVRTEDP DCPNERFLLY QEWAHPKSFY
KMQPLDLIRK YYGEKIGIYF AWLGFYTIML TLAAIVGLAC FIFGYKTQET STWSKEVCDP
EIGGKIVMCP QCDRECNYWR LNSTCEASKK LCIFDNFGTL VFAVFMSIWV TLFLEFWKRY
QAQLEYEWDT VEFLEQEEPS RPEYEAKCIY ERKNPITGVK EKVPYTGCGR CVRVSLGIGT
VIFWILLILA SIVAITVYRL AAFFAFSARL RAQDLKELEP LKEYVTPQMA TSVTASLISF
VVIMILNILY ERVAIWITNF ELPRTKTDYE NSLTLKMFLF QFVNYYSSCF YIAFFKGKAV
GFPGDPVYIM GKYRNEECDP GGCLIELTTQ LSIIMGGKAI WNNIQEVLLP WVKNLIFRYC
TSATEKIIPR WEQDYRLQPY AKLGLFYEYL EMVIQFGFVT LFVASFPLAP VLALVNNLFE
IRVDAWKITT QFRRVVPEKA QDIGAWQPIL QGVAILAVAT NAMIIAFTSD MIPRLVYYWS
FSVFPYGEHA QHTMEGYINS SLSVFNTSDF LEDSRPLGNF TNIPSCRYRD FRFPPGHPRK
YEFDMRYWHV IAAKMAFIIV VEHIVYLTKF VLSYVIPDVP YAVREQMKRE KYLTQVILHE
TNLKLVTKRL RPVANDDEIK ETQAGLSMEE LDPDL
//