ID H2V052_TAKRU Unreviewed; 586 AA.
AC H2V052;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Acid-sensing (proton-gated) ion channel 2 {ECO:0000313|Ensembl:ENSTRUP00000042582.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042582.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042582.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042582.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2V052; -.
DR STRING; 31033.ENSTRUP00000042582; -.
DR Ensembl; ENSTRUT00000042726.3; ENSTRUP00000042582.3; ENSTRUG00000016649.3.
DR GeneTree; ENSGT00940000154991; -.
DR InParanoid; H2V052; -.
DR OMA; GQFHHVT; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
SQ SEQUENCE 586 AA; 65643 MW; C41EEFC6AF2D4C86 CRC64;
MAVFTFQSLS PHLAAPYHPP RRVLWDHRGF VDCTQGIRCD SGLRISHFHT LSSRVCRCEA
PRGSPAGVLM MDLKEACGSQ GSQESSSLHP TSWQAFAHSS TLHGLRFIFP YGQPTARSLL
WAVALLACLG LLALESAERL AYFLSYPHVT SVDAVVSGSL IFPVVTICNL NAYRFSRLTR
NDLYHAGELL ALLDVHLTIP QPHLADPDVL AFLQEKANFT AYRPKTFSMK EFVERVGHDL
KEMMLYCRFQ GQECNHSDFK AVFTRYGKCY MFNAAEEGKT LRTTMKGGTG NGLEIMLDIQ
QDEYLPVWGD SEDTAFEAGV RVQIHSQAEP PFVHELGFGV APGFQTFVAT QEQRLTYLPP
PWGECEAKAL GFFHVYSVTA CRIDCETRYI VENCNCRMVH MPGDASYCTP EQYKDCAEPA
LAKLSAVENS NCMCRTPCNM TRYNKELSMV KIPSKTSARY LQKKFNKSEK YITDNILVLD
VFFEALNYET IEQKKAYEVA GLLGDIGGQM GLFIGASILT ILELFDYAYE VLKERLLDLL
SREEEEESRG EDVSSCDPVA NHSESISHTV TIPLQTTLGT LEEIAC
//
