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Database: UniProt
Entry: H2V0C9_TAKRU
LinkDB: H2V0C9_TAKRU
Original site: H2V0C9_TAKRU 
ID   H2V0C9_TAKRU            Unreviewed;       457 AA.
AC   H2V0C9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-JUN-2018, entry version 36.
DE   SubName: Full=Lipase, endothelial {ECO:0000313|Ensembl:ENSTRUP00000042659};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042659, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000042659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000042659}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   STRING; 31033.ENSTRUP00000042659; -.
DR   Ensembl; ENSTRUT00000042803; ENSTRUP00000042659; ENSTRUG00000016676.
DR   eggNOG; ENOG410IJUA; Eukaryota.
DR   eggNOG; ENOG4111GMM; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; H2V0C9; -.
DR   OMA; LKIKLTW; -.
DR   OrthoDB; EOG091G052B; -.
DR   TreeFam; TF324997; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002330; Lipo_Lipase.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00822; LIPOLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306}.
FT   DOMAIN      304    439       PLAT. {ECO:0000259|PROSITE:PS50095}.
FT   ACT_SITE    127    127       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    151    151       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    231    231       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   457 AA;  51642 MW;  0B9FA36ADB8194A4 CRC64;
     SSALGAVKYN MRKSLDLDQV GCYLQAGKKG CLEECGFNAT TKTIFIIHGW TISGIFESWM
     YKLVSAVMQR ETEANVVIVD WLPMAQQLYP DAVNYTHAVG LDIAAMLNWL QDEQQLALQN
     VHLIGYSLGA HVAGYAGTHV RGTIGRITGL DPAGPLFEDV EKERRLSPDD ADFVDVLHTY
     TREPLGVSIG IKRPIGDIDI YPNGGEVQPG CTLGDVLAVA GNVMDMMKCE HERAVHLFVD
     SLMNRDHVSF AYQCTGPDRF RKGICLSCRK NRCNNIGYNA RKMRKRRNSK MYLKTRADTP
     FGGYHYQMKM HVFNRKRSDN AEPTFYVQLH GAHKDTDNIL VDVFEGDIGL NLTNTFLVFT
     EEDIGDLLKI RLNWEGEADS WNSLWKNLKK SFWGWKAKPV LQVRRIRVKA GETQKKFTFC
     AEDPEKINIS PGESLNFLKC RDGWEVKPRK STFAGRG
//
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