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Database: UniProt
Entry: H2V2J8_TAKRU
LinkDB: H2V2J8_TAKRU
Original site: H2V2J8_TAKRU 
ID   H2V2J8_TAKRU            Unreviewed;      5004 AA.
AC   H2V2J8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000043429};
GN   Name=LOC101072939 {ECO:0000313|Ensembl:ENSTRUP00000043429};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043429, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000043429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000043429}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSTRUT00000043574; ENSTRUP00000043429; ENSTRUG00000016954.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4314   4337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4535   4555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4609   4630       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4747   4768       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4806   4826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4885   4908       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    219       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      227    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    345       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      353    410       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      613    812       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1028   1224       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1362   1572       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     2044   2064       {ECO:0000256|SAM:Coils}.
FT   COILED     3657   3677       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5004 AA;  567297 MW;  58420F151FEA09B1 CRC64;
     MAEGADGEEE IQFLRTGDHV VLQCTASILK EQIKVCLSCE GFGNRLCFLE TTSNAQSVPP
     DLAICCFILE QSLSVRALQE MLSNTSLDEV RGQAVDLDKW NFFYQSSQGG GHRTLLYGHA
     ILLRHTHSSM YLSCLTTSRS LTDKLAFDVG LQEDSTGEAC WWTIHPASKQ RSEGEKVRVG
     DDLILVSVSS ERYLHLSYAS GDLMVDASFM QTLWTMTPVM SGCELAEGFL SGGYVLRLFH
     GHMDECLAIP GAEQGDDQRR VVHYEGGAVC SHARSLWRLE PLRIGWSGSH IKWGQSFRIR
     HITTGRYLFL DEDKGLLLVD AEKANSKMSA FCFRISKEKI EVAQKRDVEG MGTPEIKYGE
     SMCFVQHVSS GLWLTYAAVD AKSARLGPLK RKAILHKEGH MDDALTVARS QTEESQAARM
     IYSTTGLFNQ FIKGLDALSG KNKSANPPSL PMDAVVLSLQ DLIFYFRPPE EELEHEEKQF
     KLRSLKNRQN LFQEEGMITL VLDCVDRLNV YNTAAHFSEY AGEEAAESWK EIVNLLYELL
     ASLIRGNRAN CALFCDNLDW LVSKLDRLEA SSGILEVLYC VLIESPEVLN IIQENHIKSI
     ISLLDKHGRN HKVLDVLCSL CVCNGVAVRS NQNLITENLL PGRDLLLQTN IINYATSMRP
     NIFLGTCEGS TQYKKWYFEV MVDHVEPFLT AQPYHLRVGW ALTEGYSPYP GGGEGWGGNG
     VGDDLYSYGF DGLHLWSGRV PRHVASPNQH ILTAEDVVSC CLDLSVPSIS FRINGHPVRG
     MFENFNLDGL FFPVVSFSAG VTIRFLLGGR HGDFKFLPPP GYAPCYEAVL PRDRLRIEPI
     KEYKHDFEDV RNLLGPTQSL SHTAFTPCPV DTIQIVLPPH LERIREKLAE NSHELWAVTR
     IEQGWTYGPF RDDNKKLHPC LVDFQSLPEP EKNYNLAMSG ETLKTLLALG CHVGMGDEKA
     EENLKKIKLP KTYMQTSGYK PAPLDLNHVK LTPNQNTLVE RLAENGHNVW ARDRVRQGWT
     YSIVQDIVNR RNPRLVPYNL LDEKTKKTNR DTVCSAVRTL IGYGYNIEPP DQESSADGPG
     SPRGDKIRVF RAEKSYAITQ GKWYFEFEAV TVGEMRVGWA RPSVRADTEL GGDELAYVFN
     GFKAQRWHMG MESFGRQWQS GDVVGCMIDL TEMNIMFTLN GEMLISDSGS EMAFKDIEIG
     EGFIPVCSLG LSQVGRINLG QNVSSLRYFT ICGLQEGFEP FAINMKRDIT MWFSKSLPQF
     MNAPTDHPHV EVTRVDGTVE TPPCLKVTHK TFGSQNANTD LLFFRLSMPI EFHETFKVPA
     GTTLLTRAMT IPEEDVVEVD PDSDFEILKK SATRKEQEED KKEPSVPKEI PAIKNGENEK
     DASTEKSKKK GFLFKAKKAA LINPPPVVPT MPRLVEDVVP DDRDDVDIIL NTTTYYYSVR
     VFAGQEPSGI WVGWITPDYH QYDLHFDINK VRNVTVTVGD DKGNIHDSIK RSNCYMVWGG
     EFSNSQQTRV SQEDFIIGCL VDLDTGLMTF TANGKEINTF YQVEPNTKLF PAVFVLPSSQ
     NMIQFELGKL KNIMPISAAM FRSERKNTVP QCPPRLDVQM LTPVIWSRMP NHFLAPETGR
     VSERLGWIVQ CHEPLTMMAL HISEENRCID ILELSERMDL LKFHYHTLKL YGSVCALGNN
     RVAHALCSHV DESQLFYAIQ NTYLPGPIRS GFYDLLISMH LESAKRGRLG TNREFIIPMT
     DETRSITLYT DKSCALPGVG LTTCLRPKLH FSSVGFVGTN QDIYTLSPVI PLQVLKTRAL
     NMLTEAVQDG VQAMRDPVGG SVEFHFVPIL KLISTLLIMG VFDDEDVTHI LKMLEPTVFS
     GKKALVPQEE HKEETERVSG EKGAQETEKE KHLETSGESE ESLEEGLFQM KLPESVKLQM
     CTLLQYFCDC ELRHRVEAII AFSDMFVSQI QSNQRQRYNE LMLAFTMSAA ETARKTREFR
     SPPQEQVNML MNFKNCAEDE ECPIPDEVRE SMLIFHNALL THCGVHIDEE EEEQEVDNSL
     RGRLVRLLER VKKFREKKVE VQLEPQEDKK PSTLQELISH TTIHWAQESF IQNPELVRMM
     FSLLHRQYDG LGELIRALPK AYTINAVSII DTMDLLECLG QIRSLLIVQM GPEEERLMIQ
     SIGNIMSNKV FYQHPNLMRA LGMHETVMEV MVNVLGGGDS KQEIRFPRVV TNCCRFLCYF
     CRISRQNQRS MFDHLSYLLQ NSGIGLVSAG MRGSTPLDVA AASCIDNNEL ALALQEQDLE
     MVVKYLAGCG LQSCPMLLAK GYPDIGWNPC GGEKYLDFLR FAVFVNGESV EENANVVVRL
     LIRRPECFGP ALRGEGGNGL LAAIEEAIKI SEDPARDGPT TKFGGEEQHE ENRVHLGNAI
     MSFYSALIDL LGRCAPEMHL IQAGKGEALR IRAILRSLVP IEDLVGVISL PVQIPSFGKD
     NSIIEPKMSA SFVPDHKAPM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTVAFS
     TTEMALALNR YLCSAVLPLI TKCAPLFAGS DHRAIMIDSM LHTIYRLSRG RAFTKAQRDI
     IEECLMALCK HLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA
     NFGVASEEEL HLTRKLFWGI FESLAHKKFD AEIFKISMPC LCAIAGAIPP DYVDASYSSK
     TEKKASVDAE GNFDPKPVDT TNTIIPERLD AFINRYAEYT HDKWAFEKIQ NNWSYGETLD
     ENAKTHPMLR PYKTFSEKDK EIYRWPIKES IKAMIAWEWN IDKARDEEES EKKKAAARKI
     SQTAQATYDP SHGYSPQPID ITHMALSRDL QSMAEQLAEN YHNTWGRKKK LELQSKGGGT
     HPLLVPYDTL TAKEKARDRE KAYELLKFLQ LNGYAVTRGL KDMESDISSI EKRFAYGFLQ
     KLLKWMEIAQ EFIAHLGTEA VVSSGRVEKS PHEQEIKFFA KILMPLINQY FKNHCLYFLS
     TPAKVLGSGG HSSNKEKEMI ASIFCKMSAL VRHRVSLFGT DASAIVNCLH ILARSLDART
     VMKSGPEIVK AGLRSFFESA ADDIEKMVEN LKLGKVSKGN QQVKGVSQNI NYTTIALLPV
     LTSLFDHIAQ HLFGDDVILD DLQMSCYRIM CSIYSLGTVK NPHVERQRPA LGECLAHLAA
     AMPVAYLEPH LNEFNAFSVY TTKTPRERAI LGLPNEVQEL CPDIPELDVL LKEIGDLAES
     GARYTEMPHV IEITLPMLCN YLPRWWERGP ENFPEMESKI CTDVTSEHLN QLLGSIMKIV
     VNNLGIDEAS WMKRLAVFSQ PIVSRAKPEM LKSHFIPTME KLKKRTSKVV AEEDHLRMEG
     KTEADEEDGT IRDEFAVLCR DLYALYPLLI RYIDNNRARW LTCPDPDAEE LFRMVGEVFI
     FWSKSHNFKR EEQNFVVMNE INNMSFLTAD SKSKMSKGGG SDTERTKKKK RGDRYSVQTS
     LIVAALKKML PIGLNMCSPA DQELINLAKI RYSLRDTDEE VREFLQNNLH LQGKVDNPSM
     RWQMALYKEM AGKAEDADAP VKVVKRVQEV SAVLYHLEVV REEISSGRRP VTEHPFKSKK
     MVWHKLLSKQ RRRAVVACFR MTPLYNIPRH RASNMFLEGY KRNWLYTEGY AFEDRMIDDL
     SKAMEQEEGD EEEEKETKPD PLHQLILHFS RTALTEKSKL DTDHLYMAYA DIMAKSCHID
     EEEEGGEEMV ENDEDEKSFE EKEMEKQRLL YQQSRLHNRG AAEMVLQMIS ACKELGETGP
     MVTTTLKLGI SILNGGNSEV QRKMLEYLKD KKDVGFFLSV QALMQTCSVL DLNAFERQNK
     AEGLGMVSEE GTTGEKVMAD DEFTCDLFRF LQLLCEGHNN DFQNYLRTQI GSTTTINIII
     CTVDYLLRLQ ESISDFYWYY SGKDVIDDPG KKNFSKAMTV AKQIFNTLTE YIQGPCTGNQ
     QSLAHSRLWD AIVGFLHVFA HMMMKLAQDS SQIGLLKELL DLQKDMVVML LSLLEGNVVN
     GTIARQMVDM LVESSSNVEM ILKFFDMFLK LKDIVASDAF RDYVTDPRGL ISKKDFQKAM
     DSQKQYSPSE IQFLLSCSEA DENDMIHYEE FASRFQAPAK DIGFNIAVLL TNLSEHVPHD
     TRLQNFLEQA DSVLNYFRPF LGRIEIMGAS RKIERIYFEI SEVNRRQWEM PQVRESKRQF
     IFDVVNEGGE SEKMEMFVNF CEDTIFEMNI ASQISEQEEE EKGEEDDEGE DAGGEGGPGA
     GVSGGGDEDS NGEEGQPESS SAFAEFINST ISFFSIFTFR NLRRQYRRVR KMTIKEIIVA
     LSTFFWTILM SILHFIYSVC KGFFMIIWQA LFGGGLVEGA KNITVTEILA SMPDPTQDDV
     HGDGPGEPRM GEEQDPGGVT ESGETGSGEE EEEDTQDKEG GRIPGIDAPG GLGDMGVESP
     VEPPTPEGTP ITKRKKKPPE PVPVEEPPPE PEKAEVESGE KAEKEPQSNE EQLEKPKKSA
     QKKEKKVKGA EGFQIWGELE TQRNKFLNYL SRNFYNLRFL ALFLAFALNF ILLFYKVSVS
     SVQVSDTPPE GSGEEAEGSG MSDGGDENDE DMPIYFYLEE STGYMQPTLA FLAALHTVIS
     FICIIGYNCL KIPLVIFKRE KELARKLEFD GLYITEQPEE DDIKGQWDRL VLNTPSFPNN
     YWDKFVKTKV LDKYGDIYGR ERIAELLGVD LASLDVSQQH EKKQEAPDNS VFAWITSIDM
     KYQIWKFGVV FTDGTFLYLC WYTIMSLLGH YNNFFFACHL LDIAMGVKTL RTILSSVTHN
     GKQLMMTVGL LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA
     GGGIGDEIED PAGDEYELYR VVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED
     METKCFICGI GSDYFDTTPH GFETHTLDEH NLANYMFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLS
//
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