ID H2V4B7_TAKRU Unreviewed; 779 AA.
AC H2V4B7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Survival of motor neuron-related-splicing factor 30 {ECO:0000256|ARBA:ARBA00041083};
DE AltName: Full=Survival motor neuron domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042567};
DE AltName: Full=Tudor domain-containing protein 3 {ECO:0000256|ARBA:ARBA00013421};
GN Name=tdrd3 {ECO:0000313|Ensembl:ENSTRUP00000044051.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044051.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000044051.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000044051.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in spliceosome assembly.
CC {ECO:0000256|ARBA:ARBA00037618}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}. Nucleus, Cajal body
CC {ECO:0000256|ARBA:ARBA00004408}.
CC -!- SIMILARITY: Belongs to the SMN family. {ECO:0000256|ARBA:ARBA00005371}.
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DR RefSeq; XP_003969937.1; XM_003969888.2.
DR AlphaFoldDB; H2V4B7; -.
DR STRING; 31033.ENSTRUP00000044051; -.
DR Ensembl; ENSTRUT00000044199.3; ENSTRUP00000044051.3; ENSTRUG00000017194.3.
DR GeneID; 101074947; -.
DR KEGG; tru:101074947; -.
DR CTD; 81550; -.
DR eggNOG; KOG3683; Eukaryota.
DR GeneTree; ENSGT00940000155487; -.
DR InParanoid; H2V4B7; -.
DR OMA; GGHDKPN; -.
DR OrthoDB; 228723at2759; -.
DR TreeFam; TF316491; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd20413; Tudor_TDRD3; 1.
DR CDD; cd14282; UBA_TDRD3; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.40.50.770; RecQ-mediated genome instability protein Rmi1, C-terminal domain; 1.
DR InterPro; IPR042470; RMI1_N_C_sf.
DR InterPro; IPR013894; RMI1_OB.
DR InterPro; IPR010304; SMN_Tudor.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047379; Tudor_TDRD3.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041915; UBA_TDRD3.
DR PANTHER; PTHR13681; SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED; 1.
DR PANTHER; PTHR13681:SF24; TUDOR DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF08585; RMI1_N_C; 1.
DR Pfam; PF06003; SMN_Tudor; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM01161; DUF1767; 1.
DR SMART; SM00333; TUDOR; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50304; TUDOR; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 292..332
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 683..743
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 171..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 86327 MW; 72CD42FDFE98F5FA CRC64;
MADLASSLEK EGWYLTEEGI AELKGSNEKI TTNEIIRIVL DSDLRPIGRK FLPSDINSGK
TEELEGPCVL QLQKVRNISA SKDHEESQGA PRMLRLQMTD GHTICVGLEY KPLSKISLNT
PPGTKIKLLG TVQVKNGFVL LDDSNISVLG GEVEHMVEKW ELQRSLAKHS RSNIGAEGGP
PPFLPFGQKC GRNDEVDSRS LDQRKTLQSQ VVAKSSEENK EFEKQRTAAI AEVAKTKEGP
RTFGGGGNAG GNLSGASSSS RNRDSHQQRR REDRTERTER TESRQDGNYR ELVDERALRD
IMEMGFNREA ARQALMDNNN NLEVALNSLL TSSCGSRPGP VVAELNKPQS RARGKGRGRT
RNEDEENGAG GRPSGPSTLF DFLESKMGVL SIQDPKSQGP QRPHDSKANF SNSDHYPKDT
PQPRSAHGDH RQQRNDRPPR FYRDADFPKP GQEPLFNCTA STVSAQGQHG KGQERWSRGT
SDRHQNDRRE VLDGQSFPSS ATTFTRSKDP QQQTEFSGPH HQRPRNGDGG TVTGPAHRKG
VKDGAPASKM TNCTGTEPDG KGGNKRPDRT EERNSSRRKY DRQNSDNPDR HRDGGAPNAS
FRGGGAFQEA GFPQDNRIPP TVHAHLQNGD MEHKRTGPIK PPCAPIREPA PRKNPSNNPG
SKRRPGPGKG PRGPDRGHYG EHSWKPGDQC LALYWEDSKF YHARIDALHP SGSTAVVVFS
DYGNCEEVLL HNIKPVTADM LEEEDGYYDS PLEFRRGGDG QPRRTRPTQQ YYQPPRARD
//
