ID H2V5Y8_TAKRU Unreviewed; 323 AA.
AC H2V5Y8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Deoxyribonuclease-1-like 1 {ECO:0000256|ARBA:ARBA00041152};
DE AltName: Full=DNase X {ECO:0000256|ARBA:ARBA00043073};
DE AltName: Full=Deoxyribonuclease I-like 1 {ECO:0000256|ARBA:ARBA00042003};
GN Name=LOC101070408 {ECO:0000313|Ensembl:ENSTRUP00000044622.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044622.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000044622.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000044622.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNase I family.
CC {ECO:0000256|ARBA:ARBA00007359}.
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DR AlphaFoldDB; H2V5Y8; -.
DR STRING; 31033.ENSTRUP00000044622; -.
DR Ensembl; ENSTRUT00000044773.3; ENSTRUP00000044622.3; ENSTRUG00000017411.3.
DR GeneTree; ENSGT00950000182846; -.
DR InParanoid; H2V5Y8; -.
DR OMA; MWKTEDV; -.
DR OrthoDB; 5396078at2759; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0004536; F:DNA nuclease activity; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR CDD; cd10282; DNase1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR InterPro; IPR016202; DNase_I.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR11371; DEOXYRIBONUCLEASE; 1.
DR PANTHER; PTHR11371:SF28; DEOXYRIBONUCLEASE-1-LIKE 1; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR PIRSF; PIRSF000988; DNase_I_euk; 1.
DR PRINTS; PR00130; DNASEI.
DR SMART; SM00476; DNaseIc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS00919; DNASE_I_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000988-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..323
FT /note="Deoxyribonuclease-1-like 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025634491"
FT DOMAIN 27..276
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT ACT_SITE 102
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-1"
FT ACT_SITE 157
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-1"
FT DISULFID 196..233
FT /note="Essential for enzymatic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-2"
SQ SEQUENCE 323 AA; 37497 MW; 762AEE4000754C27 CRC64;
MKFSILLLIF FTDLCHVDAS SDFRICAFNL HNFGESKSKK TSVMHTLTRI IARCDVTLLQ
EVRDRKERAL PQLMELLNRY DSERRFQAVA SRRLGRSDSY QEQYVFVYRT DTATVTGQYQ
SPDNRPGDVD AFAREPFVVR FRAPKTAIKE FVLIPQHTAP ANTTKELDAL YDVLQDVRKM
WKTEDVMLLG DFNADCGYLA KKNREKLQLI TDQNLHWLIA DKTDTTVRAS TSCSYDRIVV
HGQRFANAVV PLSAKPFNFQ MEYHLTEEQA LEVSDHYPVE VLLKNAAPTL LPSCFGELTR
ETELKMFFFF FFWSSLVLQR LTW
//
