ID H2V8L9_TAKRU Unreviewed; 2500 AA.
AC H2V8L9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Neurogenic locus notch homolog protein 2 {ECO:0000313|Ensembl:ENSTRUP00000045558.3};
GN Name=LOC101080224 {ECO:0000313|Ensembl:ENSTRUP00000045558.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000045558.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000045558.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000045558.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 31033.ENSTRUP00000045558; -.
DR Ensembl; ENSTRUT00000045712.3; ENSTRUP00000045558.3; ENSTRUG00000017773.3.
DR GeneTree; ENSGT00940000155030; -.
DR InParanoid; H2V8L9; -.
DR OMA; AHMSEPP; -.
DR OrthoDB; 5473534at2759; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1990798; P:pancreas regeneration; IEA:Ensembl.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 24.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 36.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR45836:SF13; NOTCH GENE HOMOLOG 1; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 21.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 34.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 22.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 36.
DR PROSITE; PS01186; EGF_2; 30.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50258; LNR; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2500
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172480"
FT DOMAIN 24..63
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 64..107
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 149..186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 188..226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 228..265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 267..303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 305..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..381
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 382..420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 422..460
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 462..498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 500..536
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 538..574
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 576..611
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 613..649
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 651..686
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 688..724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..761
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 763..799
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 801..837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 839..877
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 879..915
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 917..953
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 955..991
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 993..1029
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1031..1067
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1069..1106
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1119..1154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1156..1192
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1194..1230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1232..1274
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1276..1314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1316..1355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1358..1395
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1396..1434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1445..1485
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1486..1529
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1890..1922
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1957..1989
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1990..2022
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2023..2055
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 2114..2169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2304..2335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2139..2153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2308..2335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2377..2414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2435..2500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 442
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 445
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 462
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 463
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 465
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 479
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 503
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 517
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 53..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 97..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 138..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 176..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 216..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 255..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 293..302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 333..342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 371..380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..439
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 433..448
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 450..459
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 466..477
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 471..486
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 504..515
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 509..524
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 526..535
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 564..573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 580..590
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 601..610
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 639..648
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 655..665
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 676..685
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 714..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..740
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 751..760
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 789..798
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 827..836
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 848..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 867..876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 905..914
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 943..952
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 981..990
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1019..1028
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1057..1066
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1096..1105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1144..1153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1182..1191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1220..1229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1264..1273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1285..1302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1304..1313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1345..1354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1385..1394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1400..1410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1424..1433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2500 AA; 268309 MW; 829307A91CD19FB8 CRC64;
MEQFPGVPSG SSIVLVLCFI HLSLALQCMD NKAPCVNNAT CVTLNNRTEY CRCAPGFLGE
YCQHKDPCQP GYCLNGGNCS VSMSAGVPVP GSATCSCPLG YAGQHCQIPQ NSTCYPNNPC
ANRGICTLLP FDKYKCECAR GWTGPGCEYE DSCLSSPCAN GGTCSTLSGG SYTCSCLPGY
TGRHCLNDTD ECAATPSICQ NEGTCINTRG SYKCMCALGF TGKHCESSYI PCSPSPCLNG
GTCNQNSETS YSCHCLPGFN GTNCENNIDD CPGHQCANRG TCIDGVNTYN CQCPPEWTGQ
HCTEDVNECH LQPNTCQNGG TCSNLFGSYV CVCVNGWSGL DCSENIDDCD TAACSPGSTC
VDRVASFVCL CPYGKTGLLC HLDDACISKP CKGGSKCDTN PISGMFNCNC PSGYTGSTCS
IDRDECSIGT NPCEHGGQCV NTEGSFTCNC AKGYAGPRCE QDVNECASNP CQNDGTCLDR
IGDYSCICMP GFGGTHCENE LNECLSSPCL NRGKCLDQVS RFVCECPAGF SGEMCQIDID
ECSSTPCLNG AKCIDLPNGY DCECAEGFKG LLCEENINDC VPEPCHHGQC KDGIATFSCE
CYAGYTGAIC NIQVQECHSN PCQNRGRCID LVNAYQCNCP PGISGVNCEI NEDDCASNLC
VYGECQDGIN EYKCVCSPGY TGDKCDVDIN ECSSNPCMSG GTCVDNVNGF HCLCPPSTYG
LLCLSGTDHC VAQPCVHGKC IEQQNGYFCQ CEAGWVGQHC EQEKDECLPN PCQNGGSCLD
RHNGFTCVCQ AGYRGVNCEK NIDECTSGPC LNQGICIDGL NSYTCQCVPP FAGEHCEVEL
DPCSSRPCQR GGVCLPSADY TYFTCRCPAG WQGLHCSEDV NECKKNPCRN GGHCINSPGS
YICKCPSGYS GHNCQTDIDD CSPNPCLNGG SCVDDVGSFS CECRPGFEGE HCEIEADECA
SQPCRNGAIC RDYVNSFVCE CRLGFDGILC DHNILECTES SCLNNGTCID DINTFSCRCL
PGFFGTFCEY EQNECDSQPC KNGGTCTDGL GTYRCTCPAG YNGQNCQNYV NLCRQVRCHN
GGSCSHTGAT SWTCHCTMGW TGPYCDVPDM SCRDFAARKG LEEENVCKNA GRCVNVGNSH
KCECQPGYTG SYCEEMVDEC KSNPCRNGAT CKDYQGTYEC ICKPGYQGVN CEYEVDECHS
KPCLHGGTCI NLINRFTCVC PSGTHGVQCE VNVDDCAPKP GSWEPRCLNG GQCLDGIGRY
TCSCPPGFVG EHCEGDLNEC LSGPCHATGS LDCVQLVNDY QCRCRLGYTG RHCDSMVDLC
LSKPCRNGGV CSMNMTSVHG YMCSCPPGFI GFNCGEIEGY TCAKLHCQNG GRCVESAGGH
LYCQCQQGFS GAHCENSQWC PWPCQNGGTC MKDSANPVQY SCHCPNNFSG RYCENNVVGS
GPSTCPYLQC KHHSADKVCD AQCNNHECDW DGGDCSLNWK QPWSNCTASV SCWDLFKNGR
CDKECDNPGC LFDGFECQKH KTCKYEKYCA DHFGNKICDP SCYTKACGWD GLDCAGDTPA
KIVPGTLVIV VLLQPKELLG DLRGFLRSLG ALLYTNLQVK LDENNKPMVY PYFGVENHGQ
QLKGSRSKRE LEKEVIGSVV HLEIDNRKCS ESSGECFSKT EEVASFLAAA HIKADLPYPL
VSVNSSPAVP IRETHILPYL VGVSVVILLL IVVLGMLAAK RKHKHGLLWL PDGFMANKND
KRREPVGQDD FDLKNFKTQD GAVLDGGQSQ RWLEDEVPPR KPRLEGKPLL PMAMDGGVDR
REWTRQHRKA ADISLTPPQA ELDSDGVDVN VKGPDGFTPL MLASLRNGGV LDCNLHGDEE
EESGGDEPGS SVISDLISQG ASLIAQTDRT GETALHLAAR YARADAAKRL LDAGADPNAH
DNMGRTPLHA AVAADAQGVF QILIRNRATE LDSRMNDGTT PLILAARLAV EGMVEELIHC
HADINAVDDH GKSALHWAAA VNNVEATLVL LKNGANRDMQ DNKEETPLFL AAREGSFEAA
QVLLDHYSNR DITDHMDRLP RDTAQERMHH DIVRLLDQYN VVHSPHNGPN LMGGAGNPSM
MCGANGAGFM NVRSGAQGKK NRRGGGVTKV GGVGGGPKEL KDMKSKRRKK PTGVEGPGAS
AGAGGASGGA AANGVNANGV KTAGALPESS VTMSPVDSLE SPHSFLGDVS GTVSTTANSP
PLLSSPTTRP MLPPVSHMLG QQQGWVGTTK HPYSDHMFSL IPHQIGGSHT GMGHSRGPMF
TPMNVTMSRE QLPPIVTFQM MAPGGGQGML KQSQTGQVQV TQSQNQSHSQ QGPGHLHCAQ
SMMYQMNEQM GIGHGLPHTV QHPHTIGHGH AGMEGQSRQL PSYQPMQSPV DKYPTPPSQH
SYTTTGSEGT TPGHSAHPPS EHPYLTPSPD SPDPWSSSSP HSNSDWSDIT TSPTPLGNPH
HTLPSSHRTH IPEQVQLQPQ SQQIQQSSQQ PQLGNMQVIA
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