GenomeNet

Database: UniProt
Entry: H2V8L9_TAKRU
LinkDB: H2V8L9_TAKRU
Original site: H2V8L9_TAKRU 
ID   H2V8L9_TAKRU            Unreviewed;      2500 AA.
AC   H2V8L9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Neurogenic locus notch homolog protein 2 {ECO:0000313|Ensembl:ENSTRUP00000045558.3};
GN   Name=LOC101080224 {ECO:0000313|Ensembl:ENSTRUP00000045558.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000045558.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000045558.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000045558.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NOTCH family.
CC       {ECO:0000256|ARBA:ARBA00005847}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 31033.ENSTRUP00000045558; -.
DR   Ensembl; ENSTRUT00000045712.3; ENSTRUP00000045558.3; ENSTRUG00000017773.3.
DR   GeneTree; ENSGT00940000155030; -.
DR   InParanoid; H2V8L9; -.
DR   OMA; AHMSEPP; -.
DR   OrthoDB; 5473534at2759; -.
DR   Proteomes; UP000005226; Chromosome 20.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR   GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR   GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:1990798; P:pancreas regeneration; IEA:Ensembl.
DR   GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR   CDD; cd00054; EGF_CA; 24.
DR   Gene3D; 3.30.300.320; -; 1.
DR   Gene3D; 3.30.70.3310; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.10.25.10; Laminin; 36.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR008297; Notch.
DR   InterPro; IPR035993; Notch-like_dom_sf.
DR   InterPro; IPR022336; Notch_2.
DR   InterPro; IPR024600; Notch_C.
DR   InterPro; IPR000800; Notch_dom.
DR   InterPro; IPR010660; Notch_NOD_dom.
DR   InterPro; IPR011656; Notch_NODP_dom.
DR   PANTHER; PTHR45836:SF13; NOTCH GENE HOMOLOG 1; 1.
DR   PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF00008; EGF; 21.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF12661; hEGF; 6.
DR   Pfam; PF06816; NOD; 1.
DR   Pfam; PF07684; NODP; 1.
DR   Pfam; PF00066; Notch; 3.
DR   PIRSF; PIRSF002279; Notch; 1.
DR   PRINTS; PR00010; EGFBLOOD.
DR   PRINTS; PR01452; LNOTCHREPEAT.
DR   PRINTS; PR01983; NOTCH.
DR   PRINTS; PR01985; NOTCH2.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM01334; DUF3454; 1.
DR   SMART; SM00181; EGF; 36.
DR   SMART; SM00179; EGF_CA; 34.
DR   SMART; SM00004; NL; 3.
DR   SMART; SM01338; NOD; 1.
DR   SMART; SM01339; NODP; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 22.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR   SUPFAM; SSF90193; Notch domain; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 3.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 22.
DR   PROSITE; PS00022; EGF_1; 36.
DR   PROSITE; PS01186; EGF_2; 30.
DR   PROSITE; PS50026; EGF_3; 36.
DR   PROSITE; PS01187; EGF_CA; 8.
DR   PROSITE; PS50258; LNR; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR002279-2};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..2500
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030172480"
FT   DOMAIN          24..63
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          64..107
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          110..148
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          149..186
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          188..226
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          228..265
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          267..303
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          305..343
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          345..381
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          382..420
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          422..460
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          462..498
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          500..536
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          538..574
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          576..611
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          613..649
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          651..686
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          688..724
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          726..761
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          763..799
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          801..837
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          839..877
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          879..915
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          917..953
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          955..991
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          993..1029
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1031..1067
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1069..1106
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1119..1154
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1156..1192
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1194..1230
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1232..1274
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1276..1314
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1316..1355
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1358..1395
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1396..1434
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1445..1485
FT                   /note="LNR"
FT                   /evidence="ECO:0000259|PROSITE:PS50258"
FT   DOMAIN          1486..1529
FT                   /note="LNR"
FT                   /evidence="ECO:0000259|PROSITE:PS50258"
FT   REPEAT          1890..1922
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1957..1989
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1990..2022
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          2023..2055
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          2114..2169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2304..2335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2352..2500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2139..2153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2308..2335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2377..2414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2435..2500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         442
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         445
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         462
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         463
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         465
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         479
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         503
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   BINDING         517
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT   DISULFID        53..62
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        97..106
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        138..147
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        176..185
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        216..225
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        255..264
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        293..302
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        333..342
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        371..380
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        391..408
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        410..419
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        426..439
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        433..448
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        450..459
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        466..477
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        471..486
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        488..497
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        504..515
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        509..524
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT   DISULFID        526..535
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT                   ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        564..573
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        580..590
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        601..610
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        639..648
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        655..665
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        676..685
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        714..723
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        730..740
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        751..760
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        789..798
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        827..836
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        848..865
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        867..876
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        905..914
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        943..952
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        981..990
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1019..1028
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1057..1066
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1096..1105
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1144..1153
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1182..1191
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1220..1229
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1264..1273
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1285..1302
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1304..1313
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1345..1354
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1385..1394
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1400..1410
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1424..1433
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2500 AA;  268309 MW;  829307A91CD19FB8 CRC64;
     MEQFPGVPSG SSIVLVLCFI HLSLALQCMD NKAPCVNNAT CVTLNNRTEY CRCAPGFLGE
     YCQHKDPCQP GYCLNGGNCS VSMSAGVPVP GSATCSCPLG YAGQHCQIPQ NSTCYPNNPC
     ANRGICTLLP FDKYKCECAR GWTGPGCEYE DSCLSSPCAN GGTCSTLSGG SYTCSCLPGY
     TGRHCLNDTD ECAATPSICQ NEGTCINTRG SYKCMCALGF TGKHCESSYI PCSPSPCLNG
     GTCNQNSETS YSCHCLPGFN GTNCENNIDD CPGHQCANRG TCIDGVNTYN CQCPPEWTGQ
     HCTEDVNECH LQPNTCQNGG TCSNLFGSYV CVCVNGWSGL DCSENIDDCD TAACSPGSTC
     VDRVASFVCL CPYGKTGLLC HLDDACISKP CKGGSKCDTN PISGMFNCNC PSGYTGSTCS
     IDRDECSIGT NPCEHGGQCV NTEGSFTCNC AKGYAGPRCE QDVNECASNP CQNDGTCLDR
     IGDYSCICMP GFGGTHCENE LNECLSSPCL NRGKCLDQVS RFVCECPAGF SGEMCQIDID
     ECSSTPCLNG AKCIDLPNGY DCECAEGFKG LLCEENINDC VPEPCHHGQC KDGIATFSCE
     CYAGYTGAIC NIQVQECHSN PCQNRGRCID LVNAYQCNCP PGISGVNCEI NEDDCASNLC
     VYGECQDGIN EYKCVCSPGY TGDKCDVDIN ECSSNPCMSG GTCVDNVNGF HCLCPPSTYG
     LLCLSGTDHC VAQPCVHGKC IEQQNGYFCQ CEAGWVGQHC EQEKDECLPN PCQNGGSCLD
     RHNGFTCVCQ AGYRGVNCEK NIDECTSGPC LNQGICIDGL NSYTCQCVPP FAGEHCEVEL
     DPCSSRPCQR GGVCLPSADY TYFTCRCPAG WQGLHCSEDV NECKKNPCRN GGHCINSPGS
     YICKCPSGYS GHNCQTDIDD CSPNPCLNGG SCVDDVGSFS CECRPGFEGE HCEIEADECA
     SQPCRNGAIC RDYVNSFVCE CRLGFDGILC DHNILECTES SCLNNGTCID DINTFSCRCL
     PGFFGTFCEY EQNECDSQPC KNGGTCTDGL GTYRCTCPAG YNGQNCQNYV NLCRQVRCHN
     GGSCSHTGAT SWTCHCTMGW TGPYCDVPDM SCRDFAARKG LEEENVCKNA GRCVNVGNSH
     KCECQPGYTG SYCEEMVDEC KSNPCRNGAT CKDYQGTYEC ICKPGYQGVN CEYEVDECHS
     KPCLHGGTCI NLINRFTCVC PSGTHGVQCE VNVDDCAPKP GSWEPRCLNG GQCLDGIGRY
     TCSCPPGFVG EHCEGDLNEC LSGPCHATGS LDCVQLVNDY QCRCRLGYTG RHCDSMVDLC
     LSKPCRNGGV CSMNMTSVHG YMCSCPPGFI GFNCGEIEGY TCAKLHCQNG GRCVESAGGH
     LYCQCQQGFS GAHCENSQWC PWPCQNGGTC MKDSANPVQY SCHCPNNFSG RYCENNVVGS
     GPSTCPYLQC KHHSADKVCD AQCNNHECDW DGGDCSLNWK QPWSNCTASV SCWDLFKNGR
     CDKECDNPGC LFDGFECQKH KTCKYEKYCA DHFGNKICDP SCYTKACGWD GLDCAGDTPA
     KIVPGTLVIV VLLQPKELLG DLRGFLRSLG ALLYTNLQVK LDENNKPMVY PYFGVENHGQ
     QLKGSRSKRE LEKEVIGSVV HLEIDNRKCS ESSGECFSKT EEVASFLAAA HIKADLPYPL
     VSVNSSPAVP IRETHILPYL VGVSVVILLL IVVLGMLAAK RKHKHGLLWL PDGFMANKND
     KRREPVGQDD FDLKNFKTQD GAVLDGGQSQ RWLEDEVPPR KPRLEGKPLL PMAMDGGVDR
     REWTRQHRKA ADISLTPPQA ELDSDGVDVN VKGPDGFTPL MLASLRNGGV LDCNLHGDEE
     EESGGDEPGS SVISDLISQG ASLIAQTDRT GETALHLAAR YARADAAKRL LDAGADPNAH
     DNMGRTPLHA AVAADAQGVF QILIRNRATE LDSRMNDGTT PLILAARLAV EGMVEELIHC
     HADINAVDDH GKSALHWAAA VNNVEATLVL LKNGANRDMQ DNKEETPLFL AAREGSFEAA
     QVLLDHYSNR DITDHMDRLP RDTAQERMHH DIVRLLDQYN VVHSPHNGPN LMGGAGNPSM
     MCGANGAGFM NVRSGAQGKK NRRGGGVTKV GGVGGGPKEL KDMKSKRRKK PTGVEGPGAS
     AGAGGASGGA AANGVNANGV KTAGALPESS VTMSPVDSLE SPHSFLGDVS GTVSTTANSP
     PLLSSPTTRP MLPPVSHMLG QQQGWVGTTK HPYSDHMFSL IPHQIGGSHT GMGHSRGPMF
     TPMNVTMSRE QLPPIVTFQM MAPGGGQGML KQSQTGQVQV TQSQNQSHSQ QGPGHLHCAQ
     SMMYQMNEQM GIGHGLPHTV QHPHTIGHGH AGMEGQSRQL PSYQPMQSPV DKYPTPPSQH
     SYTTTGSEGT TPGHSAHPPS EHPYLTPSPD SPDPWSSSSP HSNSDWSDIT TSPTPLGNPH
     HTLPSSHRTH IPEQVQLQPQ SQQIQQSSQQ PQLGNMQVIA
//
DBGET integrated database retrieval system