ID H2V9Q9_TAKRU Unreviewed; 811 AA.
AC H2V9Q9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Dipeptidyl peptidase like 6 {ECO:0000313|Ensembl:ENSTRUP00000045949.3};
GN Name=DPP6 {ECO:0000313|Ensembl:ENSTRUP00000045949.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000045949.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000045949.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000045949.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2V9Q9; -.
DR MEROPS; S09.973; -.
DR Ensembl; ENSTRUT00000046103.3; ENSTRUP00000045949.3; ENSTRUG00000017923.3.
DR GeneTree; ENSGT00940000156280; -.
DR Proteomes; UP000005226; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF206; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 ISOFORM X1; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..498
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 591..792
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 811 AA; 91741 MW; 1CBC50D16C92C116 CRC64;
MNQTAGATNA YRRCSKGGKE LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPGED
DRLALKGKVT VGDLFRKDFK VHDPNAKWIS SHDLLYRSRG GDVIKYNVET EEKSILVHNK
KFEMYKASKY EVSPDMKHVL LAYNVAPVYQ YSYTAFYIIC SLETPETWNL NPPEVRNAQL
QYAGWGPQGQ QLIFIFENNI YYRSTVESRS IRLVSTGKEG SIFNGLSDWL YEEEIFHSHI
AHWWSPDGAR LAYATINDTL VPKMELPMFT GSLYPMGKEY HYPKAGEENP VITLYVENLN
GPLHTIEMRR PDDPRIGEYY VTMVKWATST KLAVNWLNRA QNISILTLCE ATTGVCTKKH
EDESEGWLHR QNEKPLFSKD GLKLFFTRAI PQGGRGKFFH ISMSISQPNT STDTLQSITS
GDWDVTQVLA YNEDSQLIYF LSTEDGPKRR HLYSADTFGS FNRRCLSCAL SDSCGYVSGS
FSHNMSYFLL SCKGPDIPFV AIYKTQRDAE SETKDGESVS EVHKLENNEN LRLTLEALQM
PTVEYKEINM DDYTLSMQIL KPASFTGTAH YPLLLLVDGT PGGQVVTEQF HMDWATVLAS
SFGAVVVRCD GRGSGFQGTN LLHRIQKRLG VFEEQDQKDA LSFILKEPYI DKSRVGAFGK
EYGGYLTSLL VSGEESPVKC GAILSPITDF ELYASAFSER YLGLPKPDPR AYTMANLAHR
ASQFMDKKFL IIHPTADEKV HFQHTAKFIS QLINEKANYT LQIYPDESHF LHSEATRQHL
SQSLVNFFEE CFRLPEMAFE GVLEEEGEEE G
//
