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Database: UniProt
Entry: H2VAE6_TAKRU
LinkDB: H2VAE6_TAKRU
Original site: H2VAE6_TAKRU 
ID   H2VAE6_TAKRU            Unreviewed;      4859 AA.
AC   H2VAE6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 40.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000046187};
GN   Name=LOC101061364 {ECO:0000313|Ensembl:ENSTRUP00000046187};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000046187, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000046187}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000046187}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSTRUT00000046342; ENSTRUP00000046187; ENSTRUG00000018032.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4196   4218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4402   4422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4467   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4611   4636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4659   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4740   4763       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      575    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1211       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1257   1472       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3929   3955       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     1778   1798       {ECO:0000256|SAM:Coils}.
FT   COILED     3402   3422       {ECO:0000256|SAM:Coils}.
FT   COILED     3593   3620       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4859 AA;  550010 MW;  B5527D050F232B8A CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVATIQK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGQSSE GAGQGGGHRT LLYGHAILLR HSFSDMYLTC
     LKTSRSLTDK LSFDVGLQEH STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSTERYL
     HLSISNGSTQ VDASFMQTLW NIQPTCSSGN MAVGYLIGGH VMRLCHGHDE SLTIPGAESS
     EEMQRIVNYE AGKGASKARS LWRLEPLRIS WSSSHIRWGQ AFRLRHLSTG RYLALSEDRG
     LVLQDREKSD TTATAFCFRP SKTSTQQEKS DLGAKRDIDG MGVPEIKYGD TVCFIMHVAT
     GLWLSYLAPD AKSSRLGPLK RRACLHLEGH MDDGLILQRC QHEESRAARI IRNTTFLFTN
     FIRALDRITK GGSTEVAGFV EDVLQTLNDL IEYFKQPDSE LEHEEKQCLL RSLIKRQDLF
     KEEGMLTLLS KCIDRMNLYN SAAHFAEKAG EEAGAAWKDI LNLLYELLAA LIRGNRTNCT
     QFSHKLDWLV SKLERLESSS GILEVLHCIL VESPEALNII QRAHIESIIS LLYKHGRNHK
     ILDVLCSLCV CNGVAVRANQ NLICDTLLPE RDLLLQTRLV NDVQSMRPNI FLGVADGSAQ
     YKKWYFELVI DQVDHFVTGE STHLRVGWAN TRGYAPYPGG GEGWGGNGVG DDLYSYSFDG
     LHLWSGRIPR AVASVNQHLL NSDDVVSCCL DLGAPSMSFR INGQPVQGMF EDFNTDGFFF
     PVVSFSAGVK VRFLLGGRHG DFKFLPPAGY SPCYEALLPK EKMHIEAVKD YKRDHEGVRD
     LLGTTQFLSQ SSFIPTPVDT SQVVLPTHLD NVRDKLAENI HELWGMNKIE LGWTYGKIRD
     DNKRQHPCLV DFVKLPETER NYNLQMSSET LKTLLALGCH VAQVNIHAED DLKKIKLPKD
     YMMSNGYKPA PLDLSDVKLT GGQEVLVDKL AENAHNVWAK DRIKQGWTYG IQQDVKSRRN
     PRLVPYALLD ERTKKSNRDS LREAIRTLVG YGYDIDPPDQ EGAHVVVDET IETTRLFRVE
     QTYAVKTGKW YFEFEAITGG DMRVGWARPG CRPDVELGAD DQVFVFDGYR GRRMHAGSRY
     FGHPWKKGDV VGCMINMEDK SMIFTLNGEL LITNKGSELC FTDFETEEGF IPVCSLGMSQ
     IGRMNLGKDA STFKYYTMCG LQEGFEPFAV NMKREITMWF SKRLPTFVNI QQDHAHIEVT
     RIDGTVDSPP CLKVTHKTFG TQNSNSDMLY CRLSVPVEFY SADTLLDESL RFRDFKNTGV
     RKCGCATVCF ISSQYYHSVR VFAGQDPASV WVGWVTPDYH YYSKNFNLGK TRTVTVTLGD
     ERGRVHESVQ RSNCYMVCAG DAVSPSSSSR STSDLEIGCL IDLVTGLVTF TANGKELSTV
     YQVEPNTKLF PAVFVRPTSA DLFQFEFVKM KDAMPLSSAI FKSEHRNPVP QCPPRLDVQT
     IVSVLWSRMP NTFLNVETAR VSERHGWVVQ CLEPLQIMAV HIPEENRCLD ILELSEHEDL
     RKFHYHTLML YCALCALGNT RVAHALCSHL DQSQLLYTID NQYLSGMLRE GFYSVLISIH
     LETAKEARLM MNNEFIIPVT DETRSIKLFP DESKRHSLPG VDLSTSLKPR VNFSPVGVIN
     RGRHQYLHSP QIPLGILKEK AISMLTEAVQ GGGTHIRDPV GGSVKYQFVP ILKLIGTLLI
     MGVLTSEEVR VILLMIDPNV FGEVQEGEEA RGEEAGPAAE KEEVSKNEEK AVEAGEEESK
     ESKPSATKGL LEKLLPEPVK RQMCELLQYF CDCELKHRIE SIVSFSDTFV SKLQFNQKFR
     YNELMVALNM SAAVTAKKTK EFRSPPQEQI NILLNFSAGD DCPCPEEIQE ELNSFHEELR
     LHCGIPIEEE EEDQDTSIKG RLLALLYKIK GPPQKAEKEP EKEQAAPTNL KELISQTITC
     WAQESHIQDP ELVRVMFSLL RRQYDGIGEL LRGMKKTYTI SAASVQDAIN LLASLGQIRS
     LLSVRMGKEE EKLMIDGLGD IMNNKVFYQH PNLMRVLGMH ETVMEVMVNV LGGDKSQEIA
     FPKMVASCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG LASEAMRGST PLDVAASSVM
     DNNGLALALE EPDLEKVVTY LAGCGLQSCA MLLAKGYPDL GWNPIEGERY LSFLRFAVFC
     NGESVEENAN VVVKLLIRRP ECFPALRGEG GQGLLVAMKE AIKISEDPSL DLPKIPDGVS
     AGPGEEGGEI IHMGNAIMSF YSALIDLLGR CAPEMHLINA GKGEALRIRA ILRSLVPTLD
     LVGIISIPPK MPMVNKDGSV TEPDMSACFC PDHKAPMVLF LERVYGIQDQ TFLMHMLEVG
     FLPDLRASAS LDTEALSTTE TALALNRYIG SAVLPLLTRC AALFAGTEHY TQLIDSTLQT
     IYRLCKGRSL TKAQRDAIEE CLLAICKHLR PTMMQQLLRR LVFDVPVLSE YCKIPLRLLT
     NHYEQNWKYY CLPAGMGSFG TASDEELLLT KKLFWGTFDS LSHKKYDPEL FKMATACLCA
     IAGALPPDFV DASLGATLEK QASLDSQGNF DPKPINTANI SLPEKLEYIT NKYAEHSHDK
     WSSEKVSAGW KHGESLDEHT KSHPLLKPYK ALTEKERETY RWPVRESLKS MLAMGWNIER
     SKEGEPMFQR EGDTHKKTSD PQINGFSPAP MDLHNITLSR ELQSMVEMVA ENYHNIWAKK
     KKTELISKGG GTHPLLVPYD TLTAKEKYRD REKAQELFKF LQISGYIVSR GLKDIEQDSS
     SMEKRFSYKF LKRLLQYVDS AQEFIAHLEA MATSGKTDKS PHDQEIKFFA KVLLPLTDQT
     FKNHCLYFLS TPSKNLSSCG CASNKEKEMV TSLFCKLAAL VRHRISLFGS DSTIMVSCLD
     ILTHSLDTRT VMKSGSELVK AGFRTFFENA AEDLEKLVEM LKLGKFMQSR AQMKSVSQSI
     NYVTVALLPI LTALFDHIKT HEFGIDLLLN DVQLSCYRIL TFFYSLGTGK NIFVERHLPA
     LGESLATLVG AMPVAFLEPD LNAYNPLSVF NTKTPRERAI LSMPDTVEEM CPEIPRLDKL
     LKDVNDVSES GARYSDMPQV IEVILPMLCN YLSYWWEKGP ENSPPDAQCC TMVTSEHLSV
     ILGNILRILN SNLGIDDAPW MKRIAVYSQP IICKAGAGLL RSHFLPTLVK LKKKTEKVVA
     EEELLKADSK GDNQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSRWL KEPDADSTEL
     FRMVAEIFIL WCKSHNFKRE EQNFVVQNEI NNLGFLTGEA KTKMSKSGGD QERKHKRRRG
     EYYSIPTSLI VAALKKMLPI GLNMCTPGDQ ELISVAKKRY SLKDTDDEVK EHLRQNLHLQ
     DKSDDPAVQW QLNLYRDVVV KCEEPVNPEH TVSRVQSISA ALFHLDLVEQ PLRNKKCVWQ
     KLLSKQRKRA VVACFRMAPL YNLPRYKNNN YFLNGYREVW LERAFKASSF DRLFSLLTKT
     PMKIVEEEEE EVAEIQPDPL HQLILHFSHN ALTERSHLEE DPLYIAYADM MAKSCAEDEE
     EEEEEEKEKT FEEKEMEKQK ILYQQARLHA RGAAEMVLQM ISATKEGRLG PMVTCTLKLG
     ISILNGGNVQ VQQKMLDYLK EKRDAGFFKS LSGLMQSCSV LDLNAFERQN KAEGLGMVTE
     EGSSSKVLQN DEFTKDLFRF LQLLCEGHNG DFQNFLRTQT GNTTTVNIII STVDYLLRLQ
     ESISDFYWYY SGKDVIDDTG KLNFSKALSV AKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD
     AVVGFLHVFA NMQMKLSQDA SQIELLKELM DLQKDMVVML LSLLEGNVVN GTIGKQMVDT
     LESSNNVEMI LKFFDMFLKL KDLTTSDNFR EYDPECKGII SKKEFQKSME SQKQYSQSEI
     EFLLSCAEAD ENDMFNYKEF VERFHEPAKD IGFNVVVLLT NLSEHMPHDS RLATFLDLAE
     SVLSYFEPYL GRIEIMGSAK RIERVYFEIS ESSREQWEKP QVKESKRQFI FDVVNEGGES
     EKMEMFVNFC EDTIFEMQLA SKISEPDVGE QPEEEEDDGH SILGDLVGEE DDALESASAF
     SAACRSVKRR ISKVRHLFSI KNVRKQFKKI KKLSIKEIIT GFFSFFWMLF TGFFRGIYSI
     IFGFFHIIWA SMFGGGLVEG AKNMKVTDIL GNMPDPTQFG IHGDVIEGEK VEALESSGSL
     DITMTPAGDT AEVDVMLELL TSPKKEGGKH MEPGLGDMSE LSSETAATDQ KKVRKQSRPS
     GGQKAMKTEE TPESEPEKAD TENREKEDKP TEKETKETVT EEKPKARSSR QKDEAPAFTS
     SVFALLDVYL TKLLNYLARN FYNLRFLALF VCFAINFILL FYKVAGDDTD DENRWGGDAE
     DDEDTFFDMD EFVLQESTGY MLPTLRFLAV FHTIISLLCL VGYYCLKVPV VVFKREKEIA
     RQIEFDGLYI TEQPSDDDIK GQWDRLVINT PSFPNNYWDK FIKRKVINKY GDLYGAERIA
     ELLGLDKSAL DFDPTVETVE KEASLVSWLL SSIDTKYHTW KLGVVLTDNN FLYLIWYTTM
     SIFGHFNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DELEDPAGDP YELYRILFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF DRTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPTGDCF RKQYEDQLG
//
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