ID   H2VCV2_TAKRU            Unreviewed;       967 AA.
AC   H2VCV2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Protein phosphatase 4 regulatory subunit 1 {ECO:0000313|Ensembl:ENSTRUP00000047045.3};
GN   Name=ppp4r1 {ECO:0000313|Ensembl:ENSTRUP00000047045.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047045.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000047045.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000047045.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2VCV2; -.
DR   STRING; 31033.ENSTRUP00000047045; -.
DR   Ensembl; ENSTRUT00000047204.3; ENSTRUP00000047045.3; ENSTRUG00000018385.3.
DR   eggNOG; KOG0211; Eukaryota.
DR   GeneTree; ENSGT00950000183066; -.
DR   InParanoid; H2VCV2; -.
DR   OMA; TFNRQIV; -.
DR   OrthoDB; 1367932at2759; -.
DR   TreeFam; TF105560; -.
DR   Proteomes; UP000005226; Chromosome 19.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR033461; WRNPLPNID.
DR   PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10648:SF7; WRNPLPNID DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF15017; WRNPLPNID; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          211..250
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          290..328
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          434..490
FT                   /note="Putative WW-binding"
FT                   /evidence="ECO:0000259|Pfam:PF15017"
FT   REPEAT          889..912
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          366..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..631
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   967 AA;  108896 MW;  E25CF5888F92EFB5 CRC64;
     MAGLSLYFED GHDDLDDFGF DDYGSECDGI RITAFLDAGQ DNLTPLGRLE KYAFSENVFN
     RQIVARGLLD VLREFSDNEN DFISVMETVA RMSEDGEPTV RAELMEQVPN IAMFLHESRP
     NFPAAFSRYL VPIVVRYLTD PNNQVRKTSQ AALLVLLEQG LLSKADMETK VCPVLLELTE
     PSSDDDYKIE AVAIMCKVVT MLSKDTVEHL LLPRFCDLCS DARLFQVRKV CAANFGEFCS
     IVGQEATEKL LMPKFFDLCS DSLWGIRKAC AECFMMVSNS TSPEVRRAKL SPLFISLISD
     QSRWVRQAAF QSLGRFISTF ANPSSTGLHF TEDGALLEVP RCTLDSDCSL NSLNCPDLRG
     CRTDRTVVHT PPNQDGRATP SPEHVVSADS EEMNNFDDNH SSLPGENHSG FSSRVSDSST
     NNTKNTKDTE HCDENFNSFH YWRSPLPDIS GELEILSSQK PSDVAEDEEE KEEPQNSIPD
     SMCSPGKATS DQIQKVLDCL QPHMDDPDVQ AQVQVLSAAL KAAQLDSPTD GTKTQEEQQP
     ENVGDSPSVE SKPMEDQSES DDSPSEEEQT LETLSPLESN PVQEQGDEET QTEPLDDRAD
     SPPDSPVLKS EFIDRVDEEG NEDRTHSPLS EDKPKTQNVI PQQLLDQYLS MTDPARAQTV
     DTEIAKHCAF SLPGVALTLG RQNWHCLKDT YETLASDVQW KVRRTLAFSI HELAVILGDQ
     LTAADLVPIF NGFLKDLDEV RIGVLKHLYD FLKLLHADKR REYLYQLQEF MVTDNSRNWR
     FRYELAEQLI LIIELYSHYD VYDYLRQIAL TLCSDKVSEV RWISYKLVVE ILQKLYTCGS
     DDLGLNFINE LTVRFCHCPK WVGRQAFAFI CQAVVEEDCM PMDQFSQHLL PSLLSLSSDP
     VANVRVLVAK ALRQSIMEKA YFKEPGCAYS EELEETVMAL QSDKDRDVRF FASMDPNKSL
     MDTAPLI
//