ID H2VD64_TAKRU Unreviewed; 349 AA.
AC H2VD64;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=COP9 signalosome complex subunit 4 {ECO:0000256|ARBA:ARBA00014881};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047158.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000047158.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000047158.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle {ECO:0000256|ARBA:ARBA00004234}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the CSN4 family.
CC {ECO:0000256|ARBA:ARBA00010417}.
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DR AlphaFoldDB; H2VD64; -.
DR Ensembl; ENSTRUT00000047317.3; ENSTRUP00000047158.2; ENSTRUG00000018422.3.
DR eggNOG; KOG1497; Eukaryota.
DR GeneTree; ENSGT00940000153510; -.
DR HOGENOM; CLU_028132_1_0_1; -.
DR TreeFam; TF101147; -.
DR Proteomes; UP000005226; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041406; CSN4_HTH.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR10855:SF2; COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF18420; CSN4_RPN5_eIF3a; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 136..309
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 349 AA; 39835 MW; 2545D97D04D555B0 CRC64;
MATEVRQELS QLMNSSGSHK DLAAKYRQIL DKAIQFTDAD QLESLKAFVE AMVNENVSLV
ISRQLLTDFC THLPNLPDAT AKAVYHFTLE KIQPRVISFE EQVASIRQHL ATIYEKEGDW
RNAAQVLVGI PLETGQKQYN VDYKLDTYLK IARLYLEDDD PVQAEAYINR ASLLQNESSN
EQLQIHYKVC YARVLDFRRK FIEAAQRYNE LSYKTIVHET ERLEALKHAL NCTILASAGS
SILDRAVIEH NLLSASKLYN NITFEELGAL LEIPPAKAEK IASQMITEGR MNGFIDQIDS
IVHFETREPL PTWDKQIQSL CFQVNNLLEK IRVAAPEWAA QAMETQMTQ
//
