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Database: UniProt
Entry: H2XK29_CIOIN
LinkDB: H2XK29_CIOIN
Original site: H2XK29_CIOIN 
ID   H2XK29_CIOIN            Unreviewed;       527 AA.
AC   H2XK29;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000030011};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000030011, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B.,
RA   De Tomaso A., Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M.,
RA   Harafuji N., Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T.,
RA   Lemaire P., Martinez D., Meinertzhagen I.A., Necula S., Nonaka M.,
RA   Putnam N., Rash S., Saiga H., Satake M., Terry A., Yamada L.,
RA   Wang H.G., Awazu S., Azumi K., Boore J., Branno M., Chin-Bow S.,
RA   DeSantis R., Doyle S., Francino P., Keys D.N., Haga S., Hayashi H.,
RA   Hino K., Imai K.S., Inaba K., Kano S., Kobayashi K., Kobayashi M.,
RA   Lee B.I., Makabe K.W., Manohar C., Matassi G., Medina M.,
RA   Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A.,
RA   Stainier D., Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K.,
RA   Yoshizaki F., Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C.,
RA   Doggett N., Glavina T., Hawkins T., Richardson P., Lucas S.,
RA   Kohara Y., Levine M., Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000030011}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15114417; DOI=10.1007/s00239-003-2559-6;
RA   Gissi C., Iannelli F., Pesole G.;
RT   "Complete mtDNA of Ciona intestinalis reveals extensive gene
RT   rearrangement and the presence of an atp8 and an extra trnM gene in
RT   ascidians.";
RL   J. Mol. Evol. 58:376-389(2004).
RN   [3] {ECO:0000313|Ensembl:ENSCINP00000030011}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   EMBL; EAAA01002880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7719.ENSCINP00000030011; -.
DR   Ensembl; ENSCINT00000035546; ENSCINP00000030011; ENSCING00000024776.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; H2XK29; -.
DR   OMA; AHININC; -.
DR   OrthoDB; EOG091G029I; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008144};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    326    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    407    428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      148    190       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      333    516       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   527 AA;  60836 MW;  582D4D5AE338722D CRC64;
     GDLEGLQTLF QEQTYYLFHL NVNCVDSLDR TALSLSTLNH HLDVVKFLLG EDVFGIKLGD
     ALFYAIQCEF IEAIELLLEK DPQTSLQVQP GTTSPFEPGL TPFMLAAHKN NYKILSVLYK
     MRHLINVIHD NELLQDEGFD PYSWDAVMER LLHYRARASP AFMLLMYKDP LNSSMDLFSE
     LHELARRERE VEEAYLQMAN RCETFALQLL EEVRSANELA DLMRYDLDDD MDDVSELDDP
     GESDRITPER RLQAIKYEMK DFVTSDNSQL ALIYIQKGSM FRRLKGFKGS VVQVLFGMLF
     PVLSMAFLIA PQSSFGCLMK NPTIKFWCWV ISEVVFVIML LVNTILMQTN TFKDLDAQNV
     ITDINILCLT LQISPLLVVA YFWVLGKFIQ EIREVFHQGL REYLSDVWNW NDLFTILLYT
     CFMILRIVHI IQNNGDLTRG TPYWHETMFQ ALPLSDICIA VSYILIHMRI MELLRAARRF
     GPLQVSLDLM LHDAIRFAII FGIIFLAFGS GITELYTPYG ENKNCSC
//
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