ID H2XK75_CIOIN Unreviewed; 497 AA.
AC H2XK75;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00018240};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000030057.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000030057.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC oxidoreductase family. PYROXD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008147}.
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DR EMBL; EAAA01001054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XK75; -.
DR STRING; 7719.ENSCINP00000030057; -.
DR Ensembl; ENSCINT00000033181.1; ENSCINP00000030057.1; ENSCING00000018051.1.
DR GeneTree; ENSGT00390000014894; -.
DR HOGENOM; CLU_026335_0_0_1; -.
DR InParanoid; H2XK75; -.
DR OMA; MCENLIL; -.
DR TreeFam; TF105963; -.
DR Proteomes; UP000008144; Chromosome 12.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.100; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR041575; Rubredoxin_C.
DR PANTHER; PTHR43429; PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR43429:SF2; PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF07992; Pyr_redox_2; 2.
DR Pfam; PF18267; Rubredoxin_C; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 15..169
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 289..376
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 424..475
FT /note="NADH-rubredoxin oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18267"
SQ SEQUENCE 497 AA; 54908 MW; 8854AE4811404BA1 CRC64;
IDITNSPPTG KGMFVVIGGG IAGVSCAEAL LAHSPDANVC LVSPTPIIKA ARNVNELTRN
LVTFDVTEIP VTEYESKHPN VKVHKCSAVR IDTEDKLIFM SSGETISYDK VCVCTGARQN
VIFPENNCVV GIRDTATAME LDKMLKSSER VVVVGNGGIA TELVFQIKNC EVIWAIKDKS
ISNVFFDGGA GQFFLPFLQR KQDLLKNFET EIPSKRMIYK VSDFNTTESK TLGGALGPDW
HQSLSLTGTN DDICGVNVEY ECEVQDLHVR SDNCCNLHET KKPSGEYWPL HVKLTNAVSH
ACDFVISATG VVPNVQLFTD LSCTFGLDSG IEIDENMRVV GLYDVYAAGD VCSTAKWPES
PHWHQMRLWT QARQMGLFAA QCMAGHSTMK EDIPLDICFE LFAHVTSFFG KKVVLLGNYN
AQKNNDNKNS LEFLLRVEMN EEYVKVVLFN GRVIGCVLIG ETDLEETFEN LILNQTDVSA
LGENLLDPNV DIADYFD
//
