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Database: UniProt
Entry: H2XRD5_CIOIN
LinkDB: H2XRD5_CIOIN
Original site: H2XRD5_CIOIN 
ID   H2XRD5_CIOIN            Unreviewed;      1493 AA.
AC   H2XRD5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-OCT-2019, entry version 48.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000032219};
GN   Name=LOC100184804 {ECO:0000313|Ensembl:ENSCINP00000032219};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000032219, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B.,
RA   De Tomaso A., Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M.,
RA   Harafuji N., Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T.,
RA   Lemaire P., Martinez D., Meinertzhagen I.A., Necula S., Nonaka M.,
RA   Putnam N., Rash S., Saiga H., Satake M., Terry A., Yamada L.,
RA   Wang H.G., Awazu S., Azumi K., Boore J., Branno M., Chin-Bow S.,
RA   DeSantis R., Doyle S., Francino P., Keys D.N., Haga S., Hayashi H.,
RA   Hino K., Imai K.S., Inaba K., Kano S., Kobayashi K., Kobayashi M.,
RA   Lee B.I., Makabe K.W., Manohar C., Matassi G., Medina M.,
RA   Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A.,
RA   Stainier D., Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K.,
RA   Yoshizaki F., Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C.,
RA   Doggett N., Glavina T., Hawkins T., Richardson P., Lucas S.,
RA   Kohara Y., Levine M., Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000032219}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15114417; DOI=10.1007/s00239-003-2559-6;
RA   Gissi C., Iannelli F., Pesole G.;
RT   "Complete mtDNA of Ciona intestinalis reveals extensive gene
RT   rearrangement and the presence of an atp8 and an extra trnM gene in
RT   ascidians.";
RL   J. Mol. Evol. 58:376-389(2004).
RN   [3] {ECO:0000313|Ensembl:ENSCINP00000032219}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSCINT00000032035; ENSCINP00000032219; ENSCING00000023216.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00950000182819; -.
DR   InParanoid; H2XRD5; -.
DR   OMA; HIDKVND; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 2.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT   DOMAIN      599    773       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      798    978       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1292   1487       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      979   1045       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1195   1220       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1261   1282       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    979    998       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1010   1034       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1197   1220       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1493 AA;  169650 MW;  21618B71C871E19E CRC64;
     CDAMSKEKRK SVFNIAVVGL SGTEQIKGES GVGKSCLCNR FVREEADNYY PDHTSVLSQS
     DFGGRVVNND HFLFWGDVTK KDDSGIDYKF NVIEQTEFID DQSYQPHRSS SNQLYVKRCA
     QTKISSAEKM MYICTDQLAI ESDFDVKLMP EGKVVIDGFI LCFDVSFVKY RTIDDQVRFV
     QNVYHYLAKT KKPILFALTK CDEALNPFVA EAMKFAASCG GKRSSGIPVV ETSASENINV
     TQAFLNLAQL IDKSRSKSKI ASFEDAAQVR KELLKDAKKK LETLLAHTVV KYDESWTTAR
     KTLENELDYQ RFVDLEGKNA ASKIFRKHVN RLRDEYRSEL QSKYLHYLPR ALKLILPNVV
     SLRPTWNDTL LLMSKNPKFD RCSYSTLQLV PWYEHKHINS LEDRRIPYEL LLTLEAEQIF
     RFHRQELEVV QRRCEVKDKF REMLAHSPQV TPGREWDEVA KFFKQNNFFN EISENELSTI
     YEQFQTEITE KAKENFQELL WEKLDIFASN NNGTHMDIQG IASCHDALKE DPSRYIAMAK
     LPKQRDEILN RHISETLYPP VDTWGSECLG KVLQVKRDLK SGKHQNSFIP SPSLRWQLKE
     GSDSLNVVLL GADGLSHELA NEITVHSSDD EYTLDGCIHQ LRLRSIDGNV RLLSNSFKTS
     SFSPHGCIAV YSSMESLRYI EKSLENTVMS LPDQAEAPPF QGLPVSILLA SYSNSEKEVH
     KLRDAGERLA SRIGCPFIDV LPPEYAYNRR FHESQIRLAM RSLIEGIKER AGSGRNSTVD
     PDQSGGVGVD GTLSPDLRII MCTSVGDLSA AEIALFPLLN HTSFRDCPPK DTEEEDDDAE
     LPDSVVIETY LGNRRRRIAV TLTSYQSARH LLSKGHPLHG FILVYDTMRK SSFSILKVFA
     NNTASAYPLL LLCVSPNEER PPAAAFFQQN KIARQLVVDG NTLADKLQAK FVSASSKHRH
     QPQVYSTFFK DAWEHKEDTE AIHSNDDVKE DEREENGTGS STPRSSASER KFKVGSDDYR
     PETPRFKVGS DDYRPETPRA SPTAGLIDNE FQMNPAYDNC EPYTKKTSQP SHLYPNNSTN
     APGKLNPDLL NRVAAGIKKQ PVRQALLLRQ QSLSDTLAPE PSHEPPYMTV HDPTKVGFRV
     LPPGYEQAKP LFKIQQSYII CTQVSLGRGF TSSQEDLLHP SPSVLSSSSV VKGLLERSSH
     TPKDEKLWRK EEKRRKEEEK KKVKTRILAP KLGWQGGQAY PKNLGTALII LKKEKEQRIR
     YKEKQKQNQS TRHPPNSVAI GNKHNVSDYF NKNLDEIIQG LNHMVPLFVE KCVQFLETYG
     LSTEGLYRIP ANAKERENLI RRFDEDNTIE FNATEVSVST ITGSLTWFFS QRNLPDPLIP
     YHLHDELEEA VGMPDASLKV CSVRGVIRKL PYANYATFKY LCTHLRTVSD NEAENKMSSE
     NLAICWWPTL FRPEVDLSLN SAAVAGMTKI CFRDVLLACI NQYAFIFYGK QEV
//
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