ID H2XU55_CIOIN Unreviewed; 510 AA.
AC H2XU55;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000033189.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000033189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; EAAA01000752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XU55; -.
DR STRING; 7719.ENSCINP00000033189; -.
DR Ensembl; ENSCINT00000033462.1; ENSCINP00000033189.1; ENSCING00000024017.1.
DR GeneTree; ENSGT00970000195690; -.
DR HOGENOM; CLU_534138_0_0_1; -.
DR InParanoid; H2XU55; -.
DR Proteomes; UP000008144; Chromosome 11.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF36; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 1..229
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 429..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 55420 MW; E9EDA2546F943259 CRC64;
MLIFCIDVSG SMCVSSQVKS GNGNVFVTRL QGVQQAIVDQ INKIEVTRPN TRIGLVTFSS
LVNGIGDGSP EQEILLSDFQ LYDFDFIFST GKTAPIPGTI SNTRVQLSRA LNSLNTSGGT
ALGPALLYSV ALASQRPGSQ VIVCTDGRAN MGIGSLETED DYQICHHFYD STTEMALSNG
VIVSMMSIVG TDCRLVELGR VASKTAGKVS IVDLENISKT FEDILSESVL ATQVSVQLST
HKQLFLANTK ESTGSKIEQF VGNITDQSEI TFRYGINKEE LGPATPPKVA PFQLRITYRS
LTGHQCMRVL TQDRPVTEDR VLAEMEMNPA VIGTYAAQSA AALALEGEVD EARVLSLAHK
ELVGRGMTLR NKAGASVIKT EQIYESVQKQ MDNINTTLGK VETESVSSHD SAEESRPCPL
DEVYESLPNQ PTTLQTDRPP ALPPRLYQTG RSKSTTSITN MLSKLPNIPK AIKPKKKKKA
AAREYKDDVA QKMFSFSKIT SKVFQPAAFS
//
