ID H2XW85_CIOIN Unreviewed; 535 AA.
AC H2XW85;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000033919.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000033919.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; EAAA01000758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XW85; -.
DR STRING; 7719.ENSCINP00000033919; -.
DR ESTHER; cioin-154370; Carb_B_Chordata.
DR Ensembl; ENSCINT00000030295.1; ENSCINP00000033919.1; ENSCING00000022913.1.
DR GeneTree; ENSGT00940000164234; -.
DR HOGENOM; CLU_006586_13_2_1; -.
DR InParanoid; H2XW85; -.
DR OMA; SACDHEN; -.
DR TreeFam; TF315470; -.
DR Proteomes; UP000008144; Chromosome 11.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF370; CARBOXYLIC ESTER HYDROLASE-RELATED; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 3..517
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
SQ SEQUENCE 535 AA; 59463 MW; 45343B873D5EA7D5 CRC64;
MDCPEIQIEN GRLKGKVSEP DCSNAQPVYM YLSVPYGKST SGQRRFAPPE AAENWEGTLN
ATETLTNCPQ NVGPTELYDQ MLPQKDSLNF DKNKSTEDCL RLSVFTPSTV KTSSLPVMVW
LTGGHYERNF AGRVDGTAVS GMNNVVTVVV NFRVNVFGYL SLGKDSVCPG NLALQDVILA
LKWVRQNIRA FGGNPENVTL FGESSGSGMV HLLMMSDLSK GLFHKAILLS GSTLSPFLCA
EDTSAAGEAF LNALNIDKDI GEKQVLQELR NRSIEDLMSA QSVFNDFMRC MPTIDGHVLK
DSPENLTKAG HVHRVPLLIG CTNSEGHGLI SATTYPDFFE GTAEENVKNM FQKGNAEEAF
EMLKEAYLRD VPKDDPTRYS LLHGDMVSDS IFVIPTIMTA IAHTSMGLPT YLFQMTQQPQ
FNHDETNGPG VLKKPAFVKC DHADDMHFVW GAPFVKGELP YGARFTEDEK ELSRNVMTYF
TNFAYTGNPN NGQEVPKEWP QYTLEEQNHM VLQTPLLNGQ RLNQDKVVMY TQKFP
//
