ID H2XXL5_CIOIN Unreviewed; 920 AA.
AC H2XXL5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=PLAT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000034399.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000034399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; EAAA01002474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XXL5; -.
DR Ensembl; ENSCINT00000031602.1; ENSCINP00000034399.1; ENSCING00000018397.1.
DR GeneTree; ENSGT00390000018830; -.
DR HOGENOM; CLU_291982_0_0_1; -.
DR InParanoid; H2XXL5; -.
DR OMA; HEYAFFC; -.
DR Proteomes; UP000008144; Chromosome 7.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01756; PLAT_repeat; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 3.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF7; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF01477; PLAT; 4.
DR SMART; SM00308; LH2; 3.
DR SUPFAM; SSF50353; Cytokine; 2.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 4.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS50095; PLAT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 1..43
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 74..190
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 202..320
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 665..779
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 792..912
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 920 AA; 103742 MW; FD53DD8938426686 CRC64;
FRIRVQKLYT TDGRRIETLQ DLFFGPNTFV AASREAFQPM DYRFKRVAIS DDTKGIINKY
LYNNNIKCFV STEGRWTVAI ATSELPAAGT DARVTITVYG TKGNTGPILL NDKNEPTFRS
GNEDEFSVNV GSIGEIRKIR ISHDNSGTSP GWLCESVTLT DQTTGEILQF PCNRWLSRDE
DDGEICRELP ARWSDKTVLP EITYVVTVTT GNLWNAGTSA NVHMTIFGDL GDCGPRLLQH
GGKSLPQVKG TTVVFRMQAV SLGTLYRVVI GHDGNTDGDG WFLERIAIKE DRVGSEEWIF
PCNRWLDVGE DDGKIIRELY AEAKNCFLQN PVVEVRQRKQ WDLEKWKFQR GNQIILLSHA
THNAIRVRND AGIDGLGDPS SSNCVFEVMR RRGNIRVFSN IAQSSFHLAL DQNRVLGQGK
GGSFCEFQVK VQSDRSVIFE SCKYNGQHIT FDPSGKPADT RGQPSAQGRL FTVYVKGCFR
DGSIILLNTS PTQALAVTGV GDTKGGQSGP PKQFANFRVV KVAEGVRMFQ CEKEPKRYLR
IKDGLCDGLG SGDVYCHFKV QKHKLSGYVT LQSMKHRGVF VGLNTNGKAR PTVDTGDENT
QFYPEVIKCI FPNLVFLQKI HQQFGEKKSS PAVEWRTPEP SFPNREIKYI SSQQKFVSIF
LLPDGDFRIY VTTGNNGTNE TISLTVYGEN EVSEPIVLGK GTEGGVFQCG QTDEFQANLL
KIRIIKKIRI GVEEASQDCD WRIKQVKMKD MGSNEILKFK FNRWISRSRD DGSTLRELPT
VNQDGKLNMP MLKYQVLIYT GSILGSDTDA SVYITIYGQR GDSGRRPLYK SMNNELKFQE
SQIDIFEVEA VHLGELTKNV LLSCQHEDSD WHGWYLDKLI LEDMATQKQL VFNCNRWLSK
YEDDQITVRE MPTTRQGEET
//
