ID H2XYZ3_CIOIN Unreviewed; 627 AA.
AC H2XYZ3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000034877.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000034877.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000034877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; EAAA01001645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2XYZ3; -.
DR STRING; 7719.ENSCINP00000034877; -.
DR Ensembl; ENSCINT00000030716.1; ENSCINP00000034877.1; ENSCING00000004969.3.
DR GeneTree; ENSGT00940000160454; -.
DR HOGENOM; CLU_006105_4_0_1; -.
DR InParanoid; H2XYZ3; -.
DR OMA; DKYKATT; -.
DR TreeFam; TF313309; -.
DR Proteomes; UP000008144; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IBA:GO_Central.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF200; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 11..330
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 422..611
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 627 AA; 72273 MW; 0643E341386CF9D1 CRC64;
RTKQNLPELP KENLQKFQWS ASGHDFSYVY EFNIYLYKNS FLDHHQITSN GNEQMVFNGI
ADWLFSVEIT DDDSLMWWSP DSQYLAYATI YQTDVLPFEF AVYNNYQYPE MIKFPYPKPG
TPIPFTSISV LDLNTMIVTD LTTSDFSSWS DGYYLNSVTW RGNSILSPLW KNRISNEAVV
ENCGKPDFNC SHVSEMMSKS TTGWLGHYKV AHIIPTNNEE VYLTVRSLDG FPHISVFNVN
DNKDDWRTSG DFEDEINDWI YFTSTELESK PSAGLPRIRH MWRVKGSGSD KTRFCITCSL
NTMFMDRCNW VTPSFSVDGS HVVINCGGSG NAAPLSTLHK RNAGGDFDFV RVVEGNEDLV
KTLNDYYFRE RIYGNLTLPG ISGEWFYMLQ LPPNFDESKK YPMLVQVYSG PAYQEVEDRF
GVSWKDYVSS ARDVIVMSFD GRGTGFRGDE IMHQVYRKLG QYEPHDQIAA AKKLANENSF
IDETRMAIWG WSYGGYATSR TIGEDVNNVF KCGFAVAPVT KWEYYHTIYT ERYMQQPKDN
PDGYEKSTTL QGIESFRSHH YNLFHGTRDE NVHFQNSAQL SKYLIEGDVK FGAFFAADDD
HSMSRVDNGY KNIYKLLTRQ MEICFNL
//
