ID H2Y0W3_CIOIN Unreviewed; 520 AA.
AC H2Y0W3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000035547.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000035547.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; EAAA01000753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Y0W3; -.
DR ESTHER; cioin-141645; Carb_B_Chordata.
DR Ensembl; ENSCINT00000035541.1; ENSCINP00000035547.1; ENSCING00000019431.1.
DR GeneTree; ENSGT00940000164234; -.
DR HOGENOM; CLU_006586_13_0_1; -.
DR Proteomes; UP000008144; Chromosome 11.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF370; CARBOXYLIC ESTER HYDROLASE-RELATED; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 12..509
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
SQ SEQUENCE 520 AA; 58283 MW; DAED080A505AC238 CRC64;
MPTGRVISLP NYGKVKCGKI TKAESCSVEV ENYFGIPFAK PPIGKLRFSA PQRAEPWAGI
LCEKSVKKIP LQSVGSLNLS SNFRISKNIF SQKNATEDCL YLSIYAPSIR KSHPLPVMVW
FYGGSFQMGP SVKFDATALA AMNEVIVVVP NYRVGIFGFL SLGHETECKG NMGLLDQLES
LKWVKENIEY FGGDKNNVTI FGESAGGISV HMHMMSPLSA GYFHKAISHS GTANMPGVYF
SDQQRIVTKL LESLNIKETD PSLVLHQLQN LPADQLVDYN AVQFRFGWYP TFDNHFFKTS
PEMATVAKVP FLLGCNSDEG GWLMALTTPN FISGLSKQEF SHYARILLRK YDKYLMQTID
YNKALPVLIM SLYGRMMGDC IFVNRIIQTS QANSDKGVDT FLYFMSHPPL HKHARLPDHI
GTDHADDIPF TFGLPFLPNS LKSGYRFSAD EAKLSKNMMT FFTNFAKTGN PNKPLPLETE
WPLYNSESRK HVEFTVPSIK VGSNLGQDKL HLYNKKLAKL
//
