ID H2Y5P5_CIOSA Unreviewed; 1506 AA.
AC H2Y5P5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000000643.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000000643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSCSAVT00000000650.1; ENSCSAVP00000000643.1; ENSCSAVG00000000360.1.
DR GeneTree; ENSGT00940000155894; -.
DR HOGENOM; CLU_003935_0_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF16; DH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 1..166
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 197..318
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 350..418
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 632..696
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 972..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..176
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1506 AA; 170526 MW; 49CB1802BE9DF841 CRC64;
FMERLQSRED DENDKLIPQG SVLLLLSNVE DLYKFHVDML ATIQECLQPE VSYEKQIGKA
FLKYKDRFEV YAPYCSNHER AQKKLNELTE NPETKYETSS GCLLLGNYVN DVSMEGFLLT
PIQRICKYPL LLRELYKKTP TDHPDYANVE EALNLMKEVC SNVNETKRQL EQLEKLEDLQ
ATIANWEGAN LTDTCTRSIK QGSLIKISAG NIQERQFFLF DHLLVYAKKI NALPRSKKVK
RKKAAADQKE WMFKGRISTE LMEIENLDDG TSDFHCGGYT VTNGWKVLNA AKNKWFVLLA
KDKDEKEAWL NEFVMEREKR KMSMDQRDTI DVIHGRGRRI YYKLTHQGLI KDRKSKMRTH
PKSLLGNELV QWLVDNKESK SIDEAIMLGQ ALLDCGIIHH VQDRHHFRNE GILFRFRYDD
GTFKPRGESQ DLVAKGLRIY CRVHCLFQPL VRDKDRNFRS YKQVIEKKLI DWLIDQGDCQ
SREEASNLGQ SLSLDRLDFS DDSTLFKFFP DDDLTETNKL RDLVKKSSTK HEFKFLESYK
TKTLLLMNVS DAQPLGFEAK YIEPQCAVVI TAIIRGSQAQ VQGFQPGQVI LIINNDLMTS
VASQEQFDDI MKRNLDKHKL IFVTVKAEDD VTVGIPVTKE GMGFQIRGSN PCVVHAVNKG
GMAMNCGLVK GHAIMKVNGR NVMQEPHDDV AMTIREGCKL PPSSDDDSDK VSSESDDGKV
NFYNLLLYLS LTLNDNNMIV QLMVANRHLE RLCTFGFDNV NGVRNYVLEK MSESPSIFDL
SSQLLEVLIA EDERVLSDLN HLLNHSTFII TLLHLNFSLH SRTPKCIHVE TQYLACIFSY
KRHLSSYMWP SYKESRDRPS SLTAKDFCPT NCHLNIMQVV LAVPFLLFFF AFWTIVRLIR
LVENMVHTMH SITCMAAPSF RTRGKEGHGL LAVLRGVEGN TELMDSIRQL MVGLDHALVE
LKQGQNQIIE RRKKKLLPSH PHEPQGTKKP GGGELPQKTP LTPPTIFQTN ASPTHGKVMI
VQNATNTLIV GSEEVSQTGN DSECDSGRDR VSLISGTAST CSSEGVESIN FIDLALSSDA
VDKLQGTMEH FLSKIHSLNE LVRSKTVQTV FENTQETTPN KKYNKIIEAL TARNMMALSV
CEGTDQFADV INTLIEAVDR HVNEVRTQLV LAVLLNEDPK LVSRRDKVFS QALVAAVSSF
AAQLRFAIAG NFNNMKAYGV RSEEASKKWL EQSLAIGAAV VFQSMLNPNM PDENAMLEDS
CIGINDLERV SFHFCAITDQ FVQLINFQYP FEGNRCALKV YFHLDKHVFI KLPPRLQAGG
GVKLIPMLFN HGLEDLGNQL YEQGVTMQEF NNSINEKALA KLYNYYKRFR AFHLDRSKLP
RDTEARAVLL SRPLNALDEI MGLLESNVKP RHGKPHLATS GAGVLTLAAE FCNRLGGCHV
IMCNNGVHRS TVACSLEQSL ILARCHGLPP RQLSSAALQL GHLGARTYCL KKNQEARDKT
VKSAPK
//
