ID H2Y623_CIOSA Unreviewed; 1340 AA.
AC H2Y623;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000000771.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000000771.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR Ensembl; ENSCSAVT00000000779.1; ENSCSAVP00000000771.1; ENSCSAVG00000000435.1.
DR GeneTree; ENSGT00940000168586; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 634..1073
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1237..1340
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 45..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 151012 MW; 5C7A0772791F975D CRC64;
MLQIVSEMPN RIETDMSNVL HAMRHIKMLA SDLYINENPN HLSITEKIPK PSSGSHGRPN
QPRFPKLSAT AVQTFMEETR VKGDSARPPK RITQSARRVP EGSRPASFTH RSGTTSSRRL
EVLKNCMTFI FDSKALEIKK IFQAVLRALK SRSARSALTL ELTSYSKSHP QLDNQQFDYI
ARLINSALQL NYTCIYLFNQ EVHYKVQYTS CVGFLNIPQS FVDSSGQLDE NTLAADLLPV
VTAFYRRWES KPPESRQEES SSEEGVVFSQ AMHNAQRMVF MLVPLDSTRS IRAKFLRLSH
GEENSSNSCF TNSVGGSTTG SCDEESGFEE SENSPGVAST VSKFVTKFVD RVCTEANISN
EHTKMLSNKI PTLVHMQVES LQDVCKESKR LPPIKKAKLL QPNLLMGETQ VITKPMRAYL
ASDGRATAVG GEVGGPALLP AEGAMFVTSY RVIFIGVPCD ALGDTQKLSS DKPPCQNYFL
YHDPQLNLIM FSHTLFTLNS RTLFQLRSAT FQFLLLAFDD EVSPEQQQQL QNELQKLRYP
LTIDGAFAMS AARAPRMFNS NKVNFRKKTN STSSTSSTMS SSRYKGGGGG GEGKWGGEGG
LQGIEQVKIF VKKLISEIKL AMTKTLSDKD TMHRLFQRSC ESDYKRMGLL NTEGNRYRLS
RVNRMFSVCR SYPACLVVPM SVSDEQVKSL AHCHHQSRFP CIVWMHPTSS AVLMRCSGIR
TRTASSLFKH GQSTPMSVSD EGTTGSGHEE ERFLMKIASF SSPTSRPSSQ LFREDSMSSL
SSIGTDDEVG DIKHPLEYTR VPMFNLFSFH FSLGYKFLNH RLYQVNHHRM HSNSRPLTGT
SMRSHSRKWG TLRSNGKPTN DRLSHSPVVR SNGSITQSAM YNAMSKQARV YVFGDKAQLK
VFMSSFLYGC DTVPQISSLA QIMLDPHYRT IRGFQTLVQK EWLSFGHRFS HRNRFNDVQS
SGFTPVFLQF LDAVFQLVTQ FPLSFEFNST YLELIAYHSV SNRFTTFLLD SDYERLEAGI
LFGKKAQSSK SPGHSSLNAT QCFEFDSQMN FKHHQILRPV HSLCRLKLWP YYVREALGEG
PPFDGLLGEL TSGTSHNEQE ATETSDVWGG VTGRRVVNGC YDNIADAQPD AIKMLLSQID
RLQTELGVPV DPWESTWKAV NQSTPRRSTH TNPSKLSTFH SRIFHILNVD FVQPSERLVF
SRKTGPTPPD IMVHPVNDTM DTASMYNQFQ TNTKPEVRTY EGILWKQGAY MKGWKPRFFV
LDTTKHELRQ YEAQGDNVCK SIIDLKELES VELVDPLSGA PKGTSSKSFF EVKLSKRQYH
FIAENEQAAI DWVDNLQSAL
//
