ID H2Y7L2_CIOSA Unreviewed; 2775 AA.
AC H2Y7L2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001310.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000001310.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSCSAVT00000001326.1; ENSCSAVP00000001310.1; ENSCSAVG00000000729.1.
DR GeneTree; ENSGT00940000155282; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017}; Membrane {ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 679..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 183..322
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 771..919
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1593..1648
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2775 AA; 314947 MW; E25C4B9A521E690A CRC64;
GQVEKWLLEL EADMVTSLRK VIGDSLEAFK VEARSEWVKK WPGQAVLCVT QKYWTDNVQK
ALNTGPQAME DYLALSTEQI SEIVFLVRGK LSKQNRVTLG ALITMDVHAR DVLAVLVKDK
IQSENDFAWL SQLRYYWEES NMQTRMINAG LAYGYEYLGN TPRLVITPLT DRCYRTLFGA
LNLFLGGAPE GPAGTGKTET TKDLAKAIAK QCVVFNCSDG LDYIALGKFF KGLASCGAWS
CFDEFNRIDL EVLSVVAQQI LTIQSGIRSG QDTLLFEGTE IKLDVTCAVF ITMNPGYAGR
SELPDNLKAL FRPVAMMVPD YAMISEIMLY SCGFVNARPL SVKIVATYRL CSEQLSSQHH
YDYGMRAVKS VLTAAANLKL AYPDENEDIL MLRSIIDVNL PKFLAHDLPL FNGITSDLFP
GIKLPKPDYS HLLEAIKNQC DKLNLQMTDF FTQKILQIYE MLIVRHGFMI VGESFGGKTS
AYRILAGALT EIHEKVQITV LNPKAVTMGQ LYGSFDPISH EWSDGVLAVS YRQFASSQTP
DRKWLIFDGP VDAIWIENMN TVLDDNKKLC LMSGEIIQMS PPMSLMFEPM DLEVASPATV
SRCGMIYMEP HMLGWRPLLI SWLSVLPRSQ PQNNLTFLVF IQISGLFLKF RSLFEFLVFV
KISGLCLSFW SLFKFLVFIQ VFGLYLSFWS LLKFLVFIKI SGLYSSFWSL FKILVFIKIY
GLYLSFFVFD QVSGLYSNAA PLAKDEMFNE ITIPTQDTVR YTYLINLLVT HQVPVLLVGP
TGTGKSVYIN NFLANQLDKD SYKPMNINFS AQTTAKQTQN IIMSKLDKRR KGVFGPPLGK
KTVVFVDDIN MPQREVYGAQ PPIELLRQWL DHWNWYDLTD CTMIKLVDIQ VLAAMGPPGG
GRNPITPRFL RHFNTITINV FDNDAMSTIF TRIMNWHFSI RNAFDSSFMS LVPQIVKGTS
EIYQSAAQNL LPTPAKSHYL FNLRDFSRIV GGICLSTPLS APEPNSIKRL WFHEVLRVYY
DRLVDDTDKK WLFDHLKEVD DLRSLMFCDF TPKNENKLYV EVENIDKLRE VVEGHLDEFN
NMSKKPMNLV IFRFAIEHVS RISRILKQPR SHALLVGVGG SGRQSLTRLA SHMADYELFQ
VEISKGYTSV EWREDLKVIL RKSTEGEQHG AFLFTDVQIK EESFLEDINN LLNTGEVPNL
FATDEKQEII EKMRQIDRQR DKSKQTDGTP VALFQLFIDR CRDQLHIILA MSPIGDAFRT
RLRKFPSLVN CCTIDWFQSW PEDALTAVAS RFLEDVEMSD EHRIGCIEMC KRFHTSTRTL
SERFMNELQR HNYVTPTSYL ELINTFKSLL GKKRTEVHKL KRRYEVGLEK LNSAASQVAD
MQKELTDLQP QLVVASKEVD EIMVNVERES IEVAKVEKVV KADEAVANEQ ASVAKGIKDE
CDADLAEAIP ILEAALSALN TLTPADITVV KSMKNPPAPV KLTMETICIL KNIKPERIPD
PSGSGNFCVN KCNDFLQGLQ EYDKDNIPPN LMKIIRQKYI PNPEFVPEKI RNASTACGLC
KWVRAMDSYD RVAKVVAPKK IKLKGKSGAE AELKVAMDSL RKKQAALKEV QDKLQILQDK
LEFNKQKKAD LENQVDLCSK KLNRATQLIE SLGGEKDRWG ETAHALGITF NNLTGDVLIA
SGIVAYLGTF TSKFREWLKN CRADGIPCTD NVTLHMVLGE PVKIRQWNIS GLPTDSFSVE
NGIIISNARR WPLMIDPQGQ ANKWIKNMER ANNLHVIKLS DSDFVRTLEN CIQFGTPVLL
ENIGEELDPL LEPLLLKQTF KQAGAICIRL GDSTIEYSHD FRFYITTKLR NPHYLPETSV
KVTLLNFMIT MEGLQDQLLG IVVARERPEL EEEKNALILQ SAENKKQLKE IEDKILEVLS
TSEGNILEDE TAIKVLSSSK TLANEISEKQ AIAEETEQKI DTARMGYKPI SIHSAILFFC
ITDLANIDPM YQYSLTWYVN LFVNAIDNAE KSDILEKRLE HLRNYMTYSL YCNICRSLFE
KDKLLFSILL CVNLLRHEGI VDDNDWRFLL TGGVGLDNPH SNPATWLPTK SWDELCRLDN
LNHFQGIRKK FPAYKEQWKV IYDSSDPHNK IPPGDWSELV EFHRMMLLRC LRPDKMVPAM
QNFITNNLGR KFIEPPPFDL PKTFADSNST SPLIFVLSPG ADPMASLLKF ADDQVGFGGP
KMTSLSLGQG QGPIAMRMID KAIKEGTWVV LQNCHLATSW MSTLEKICEE TLNPDKIHPD
FRLWLTSYPS NNFPVAVLQN GVKMTNEPPK GLKSNILRSY LSDPISDPEF FSSCKQPVAF
KRLLFGLCFF HALVQGEQFG PLGWNIPYEF NETDLRISVR QLHMFLNQYE FVPISALKYL
AGECNYGGRV TDDWDRRTLN SILARGYSSN VVDNETWPPE GDWESYLDFC KNLPLLAEPQ
VFAMHANADI TKDQNATQEL FNSILLTLSR TSGGGGDSND TLVFNVAGDI LGKLPPNFDT
EAALRRYPTA YKQSMNTVLV QEMVRFNVLT TTIRNSLVNV QKAIKGLVVM SADLEEVLNS
VLQGKIPQMW MKKSYPSLKP LGGYTNDFLE RLHFLEHWYQ NGPPPQFWVS GFFFTQAFLT
GVQQNFARKY TIPIDLLGFD YIKYSLEFHN ISHPGAYIYG LYVEGARWDR KAKLLAESIP
KVLHDPMPKI LLVPTKKSDI PDKPSYLSPV YKTTERRGVL STTGHSTNFV IGMTLNSDKP
PEHWIGRGVA LICQL
//
