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Database: UniProt
Entry: H2Y882_CIOSA
LinkDB: H2Y882_CIOSA
Original site: H2Y882_CIOSA 
ID   H2Y882_CIOSA            Unreviewed;      4798 AA.
AC   H2Y882;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001530};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001530, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001530}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSCSAVT00000001550; ENSCSAVP00000001530; ENSCSAVG00000000873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000168850; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4161   4179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4349   4370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4410   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4539   4558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4601   4621       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4675   4698       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      579    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      559    579       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4798 AA;  543332 MW;  95D555038D5F1943 CRC64;
     VTMDGDGDEE VHFLRTEDEI YLQCVTQKDH QGKLCLAAEG FGNRLCYVEQ SHEDKDSRPT
     DAPRCVFVLA QALSVRALQE LLAKDEIEDG STHSRTLLYG NAVQLKHGLS AMYLTCLTTA
     SSSCDKLAFD VGISEDQSGE ASWWTVHPTS KQRSEGEKVR IGDDLILISI ASERYLHLSC
     GDPGGVNVEA SFQHSMWTVA PIASGGSKVE GYLTGGDVIR LFHGHMDDCL TVDSAEEMKS
     HTRPIVYESG RAGSHARSLW RLELLQIKWF GSHVAWGIPF RLRHITSGLY LSVMDDQSLG
     LTSPEGATYR TAVFCWQASK DRPESKADHE IDGMGAPEIK YGDSVCYLQH VDSGLWMTYQ
     TIDTKSGRCG PKQRMAVLHD DGRMDDGFML SRAHPGEART ATIIRRTTEI FCNFINALDS
     HQNKKMSRRP EQPNVEEVEQ CVDDLIEYFQ EGRGEEGGHE VHQHIVQELK NRQDLFQEED
     AVSHVLQCID KLAVYGDAGN FAQIVGVEAS ASYESLLNSM YVLLAATVRG NRNNCSKFAP
     HLDWLVGQLD GQQAAMGILE VLAAVLEDSQ EALNMMKQDH IRSIISLLEK QCRNPKVLEV
     LSSLCVCNGV AVRGNQNLIC ETLLPGRDLL LQTALQSYIT NVQPNIYMGV SNACAQYKKW
     YYEVIVEAVD RSTFAGHLRV GWANTEGFSP YPVGGDYYGE NGVGDDMHSF GFDGINLWTS
     HRACPVGSNN RHILAPNDII SCCMDLSIPT ISFRINGQPV QGMFEDFNLN GLFFPVVSFS
     PGVKVRFLFG GPHGEFRFLP PVGYAPAYEA LLPGRRLFLS PCKTYGNLSR GHLMGPGSSW
     ERTVFVPNAV NTQNVILSHY LQNVVPKLES IHELWAMNRI RGGWSYGTVR DEAKKQNPCL
     VEFARLPEQE RSFNLTMSYE TLRTIIALGY HVGIADEEAE HGLRKLKLPR SYIMASGYKP
     SPLDLSHVKL TNQMEDLVEK LADNAHNVWA RERVKQGWTY GVNLDVGKKR NPRLVPFQLL
     DELAKQSNRN SIRELVRTLI GHGYMIEPPD DRLKDKTTRI KNPVQNNKVR IFRAEKTHSV
     CAGKWYFEFT IETQGVMKVG WVDPDCLPSV DLGSNHQAYV FDGVNALKLN DGSETFGQRW
     KPGDVVGCLL DFSERKIFFS LNGELLVDRC GHETAFRNLP SDLTLVPAVS LSVDQRGTLN
     LGKDPDSFQF YSTVGQKEGY QPFAAGMRCG VAMWFTKNLP SFCNLDPVHG NIEVKRLSAS
     HHKPPRLKVM YKLIGGSRSH DHQEWVYTRL NLPVSTDARL TLYEGFQAQK MLNSHLMRST
     QYSFSVRIFP EQDLGSLYVG WVTSDFHWNV DNFQRGLIPT VTITLGDNKG KISERYLRSN
     CFVLCCGDLP QQAMPPNQSS PGIVVTCIID TATGLLTFAA NGSDLNTFFQ VEPNVELYPA
     VIALPTAHNI FQYELGRTKH IMPLSAAVLK CERKNVVPQC PPRLQVQTLE QVSWTRMPGR
     LPRPECRRDM DRTKGWTSES KSSDSDAYNV VVVHIPEENR CIDLLELGEN ADLLRFHERT
     LKLYSSMCAL GNHRVAHALC SYIDEKQLMR IIRTEGLVGS VRAAYHDLLI EMHLSPHANA
     RRNTQHEYMF PLNDNTQSIG LFSDPASKRP MVPGVGPSSS IRPTLHWSPI NVVMHLIHDV
     PLEVPEFPLD ELRQNVIGQL HEAIRACYRK CKDSTGKNQE YLLVPPLRLA LTLLTMGVFN
     DEDITKLLIL LAPSFIRTLV EDESLSDLIE DSHCGLLGLQ LVESVKLEAC LLLEHLMELV
     LRHRVEALVS FSCVIVEELQ QDQKSRYQGV MEAINMSAAM TAKMTREFRS PPLEQMAILL
     NEELEENCPL PQHIKDLLWN FHTDMLLDCG EQIEEEPVEE DNQDTLRSKL SSIVSRILHK
     RKEEEESPEE SSHATVGGGS FRDLIISTMM GWARGPSINN PQLVRAIFRL LYRQYNGVGE
     MQNALMKTYC ISAASEGDTM ALLESLSRLR SLLSVQLGQD EETLIIKGLN SIMNNKVFYQ
     HPNLMRILCM HETVMEVMVS VLDGDGDSDS IVKFPRMVAA CCRFLCYFCR ISRLNQGAMF
     EHLGFLLEHS SVGLATPSMR GSTPLDVAAA SVMDNNELAL ALKESDLAKL VEQLATCGVE
     SSQLLLRKGY PDIGWNPVEG ERYLDFLKNA VFVNGESVEE NANLVVRQLI RQTECLGPSL
     RGEGGHGLLA AITSALQICR DRSRDGPDLN LCNEYDNDDD IHMGFSILAF YSTLIDLLGR
     CAPEKYLIMQ GKSDAIRIRS ILRSLVPRED LIGVISLPFD LPRFERGSTN IREPDLSACF
     IPDHKASMVL FLERVYGIDS PHLLLRLLES GLLPDMKSAA QLDVPHINST DMALALNRYM
     CHSVLPLLVK HVSLLAHCQH RPQLLDQLLH TIYRMSQAQA LTKAQKEMIS ECLVAVASVL
     QPSLLQGLLR KLTFDVPALT EETYIPLQLL KEHYSRCWKY YYLLEGCPDF GVATDEEKHI
     TMVLFWGIFD SLVKKPYSQE LFSKVLPCLC SIGNALPPDY ALSPALEKLH QQSSIDSHGK
     FHPQPVDTKS ILFPEKLDVF VNKCSEQWHD TWALERFTLG WSYEAHYNEA LKQHPMLKPY
     RLLNDREKDV YRPSVREGIK ALIAWGWSFK KIVEATDISQ LPAKVRCSSQ SNITASDAHG
     YLPRPYDLSG VSLGREMMRT AEMLAENFHL VWARKKMGEL ESKHTNLPSH PMLVPYDRLT
     AKEKERDRGK AYDLLKFFQF NNYVMSKAEK EEVDVKSSVE KRFSSMVLQR LLSYVQQRQQ
     EHAAFGGNYE PPSLQQPQAN DDIKFFAKVA MPLMESYFKN QEIYYVEACG NANDGIACRK
     PNAFILSRLF CKMALLIRQR ITMFGVDAGT AINCVKILAE CIDASTITKA CSESMKQALI
     SFFNNAADDL KLMLNHIRSG RIKILQTMVA GAHTSNYVSH CLLPLLTILF RHLGRHNFGG
     ELLLDEIQVS CYKILNGLYS LGTGKSAFID RHRAQVGECL AAFASAFPVS FLEPKLNKFN
     SYSIYNILSI KDRKALGLPP NLEQLTPHLP ILETLLADIN HLADSGAKYE EAPEMIDIIL
     PLICSYLPPW LKQGPDDNSA VSTGFSSSVS SKVLDVVLRD VLRLIHNNLG TDEADWMRRI
     AVYTQPIMVR SDPDLLADHF LPMIIKLSKR IEQARDLEEQ VKYDQRVNDV SDLELLMLED
     YGIISRDLYA FYPLMVRYID LSKSCWIRER NPIALQLFRI ISKIMIIWSK SINFRREEQN
     FVVQNEIDNM SVLTADKSAT PSAASMLVSM ISIQRVVKRR GDRYSPSTSL VVACLKRMMP
     VAINTGHVAD FQLLQEAKSR FVQRDTEDDI REYLVQVLNV SDTTWRPQLN CFVRLHSFMS
     FQSEGTSTNE SQDKVESRAD WLLEIARAQH YLFMVDHPPK SRRAVWKKLM SKQRKRAVVS
     CFRMVPLYNL PKHKVISMFI PSYAQHWVAA DQTKFAGVLI KAVNKPSVEG ESGGSDPLQQ
     LISVFSISAI TSLIHRAIED DDLYLSYAEL MAESCHTGDD DDEEEEKSFE EKEKEKQRLL
     YEQKRLATRG VAEMVLYMIS ASGGEVSDTV LSTLQLGIAL LTGGNVLVQK TMLAHLQAKK
     DVRFFTSLAG LMQQCSVLDL NAYERCLKSE SLGHASEGTV TGGETMGDAE LTCALFRFLQ
     LLCEGHNGDF QNYLRSQVGN NTTVNIIIST VDYLLRLQEA ITDFYWYYSA KDTIDAPGRE
     NFSKAIEVAK QVFNSLTEYI QGPCEGNQQA LAHSRLWDAV VGFLHVFAHM QMKLAQDSTR
     QLSLLKELLD LQQDMIVMLL SMLEGNVVNG TIGKQLVDTL IESSHNVGLI LKFFNMFLRL
     KDITESEKFT EYDPEHNGVV SRRDFHKAME ASKVYSREEI DFLLRCAVTT DDDKLNYMDF
     TEQFHGPAAD IGFNMAVLLT NLSEHMPHDT RLGKFLEMAE AMLEYFQPNL GRIEIVGGAR
     RIERVYFNIR PSSLEQWQKP QVQESKRQFF FDVINDEGEG GRMEEFVNFC EDTIFEMQLA
     SQISETGFGS SSTGPTNDDV DDEDVETISD DFTPHINMKS IKHQAKRLWG MTWMELLKTF
     FFFLLASSFQ LFQYGIDTLR YLWSLMFIVF FSNKLVVALK SKRVSEVVGE MPSPTQHGVE
     DGVLDEDASD ASDPLKSDRD DLIVDVFGMD IKGSGHAEYD RIRLRQRVQH TTSNSDQETE
     EIIAQRKETR SHYSEHPDAQ EASTLSRTMS FDMTTADDSS CTPWQSCMSA CGRPARYKQQ
     EIVEDKNAAY LDCLNSFCMG TLGLFARNFY NFKILALIIT FIINFFLLFY KVSGCDKSYW
     QSINEDLDVD ESERLVLVDT TLYMEPALKI FRAIHFILSF SMLVSYYGLK VPLVIFKREK
     EIARKLEFGG LYVSEDPSDD DLSGRWDRLV VSAPSFPSNY WDKFIKKKVL DKFGEQCGVE
     RIRELLGMSE SSTSFVEDEE PIKGNIITQL LKVDLKYTIW KVGVVFCDQS FLYLLWYFTM
     SIFGQYNHFF FSLHLLDIAA CSKGLRTILT SVTHNGKQLV LTIGLLTVVV YLYTVVAFNF
     FKKFYNKGEN DEDDWKCNSM FTCFQFHFYS GVRAGGGIGD ELDDPSGDAW EFYRIAFDIS
     FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMDTKCF ICTIGIDYFD QVPHGFESHT
     MQEHNLANYM FFLMHLINKD ETEHTGQETY VWQQYQERCW EFFPAGDCFR KQYENELS
//
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