ID H2YAX9_CIOSA Unreviewed; 4433 AA.
AC H2YAX9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000002477.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000002477.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 51511.ENSCSAVP00000002477; -.
DR Ensembl; ENSCSAVT00000002518.1; ENSCSAVP00000002477.1; ENSCSAVG00000001468.1.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000165769; -.
DR InParanoid; H2YAX9; -.
DR OMA; RTCQPEQ; -.
DR TreeFam; TF315253; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 32.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 36.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF00057; Ldl_recept_a; 33.
DR Pfam; PF00058; Ldl_recept_b; 8.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00192; LDLa; 36.
DR SMART; SM00135; LY; 37.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 36.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS01209; LDLRA_1; 16.
DR PROSITE; PS50068; LDLRA_2; 36.
DR PROSITE; PS51120; LDLRB; 20.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4408..4428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 409..451
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 452..494
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 495..539
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 540..584
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 813..856
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 857..900
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1380..1418
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 1462..1504
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1505..1547
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1550..1593
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1773..1815
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1869..1915
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2193..2236
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2237..2280
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2465..2506
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2507..2549
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2550..2592
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3218..3260
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3312..3355
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3356..3398
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4138..4179
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4360..4394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 1..13
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 44..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 83..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 90..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 102..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 127..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 139..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 202..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 209..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 221..236
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1003..1015
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1010..1028
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1051..1063
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1058..1076
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1070..1085
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1091..1103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1098..1116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1110..1125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1133..1145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1140..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1152..1167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1193..1208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1257..1269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1264..1282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1276..1291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2680..2692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2687..2705
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2721..2733
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2728..2746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2740..2755
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2760..2772
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2767..2785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2886..2898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2893..2911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2974..2986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2981..2999
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3014..3026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3021..3039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3033..3048
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3055..3067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3062..3080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3074..3089
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3535..3547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3542..3560
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3554..3569
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3574..3586
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3581..3599
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3615..3627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3622..3640
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3679..3694
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3707..3725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3719..3734
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3739..3751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3746..3764
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3758..3773
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3778..3790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3785..3803
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3797..3812
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3822..3834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3829..3847
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3909..3921
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3916..3934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3928..3943
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4384..4393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4433 AA; 492223 MW; 02D1B003E365D713 CRC64;
CPSDQFECEN GACIDLSWVC DGVTDCLGET VPGSDEEDCP AASCRSSEFQ CSDGSCILSE
FRCDGDPDCS DGGDEQACPG ATCSSSEFTC ANNYCIDADL KCDHVNDCPD NSDEQGCSYP
TCDELKCKNG ACFTSAQRCD GNVDCRDESD EFNCSESSTQ CSSNEFQCDN GKCIPQSFYC
DVWNNCGDGS DEPDGVCVYP SCPGNTFTCD NSVCVNQEWV CDGTDNCGDG SDEENCDYAI
PCLNNQWRCT NSSRCINVVQ ICDGKIDCED GTDESQTGSV CSSTKCGILS CDGYCRATPQ
GGTCYCDDGY QVGDDGISCK DFDECTVFGQ CEQKCENTVG SFKCGCADGY IPEQSHDHLH
CKATPTAGAP RLLFSAGPNI YFNDFLNDKL DIAVEAGSPI GVDYHYELGK IFWSDAILQK
VMSANTDGNN QKVILDKAIS DPEQVAVDWI GNNLYVVETK VGRIDICNFD GSHRTGVVTN
GLRNPRGLAL DPTKGYMFFT DWYTTTARLD RAYMDGSELY TIVDTSVGYP SGITVDFTNS
RVYWVDTKFD YVETVDYNGK NRRTILSGSH LLPWPYDVTL FEEHVYISDA TKLGILRGNK
FNGSIDYALV TKTGVIPNGL IAYHPSRQPK VDNPCAVQNG GCAHLCVLSH VLDGLGYSCL
CDLGYVLNMD RKSCKHSDDF ILAASYGSIQ GIPTGRFQQT DAMLPILSNG QQYFMSVTSD
AVNGYIYYGE NGKDIIYRTL MNGTGKAEEI VTNRVRLIRA LALDWTTGNL YIVDSSMDRI
TVVNTKDPTN LRKTVVSGDV WSPTSIAISP NRGYMVWTDT YRPARIERAW MDGSNRMSLV
NQTLYYPQAI TIDLVTGYVY WIDSGFDRIE RISINGYSRK EVLVSQAISY PRAITFLNDY
IYWYDGRYNS LFRVPDFVTS QTLQTETVRS GLYSVYTLDA FNKDIQNRYM NNQCNRASLP
NGGCQLLCFP APLNSRTCGC PDNMLPDGNN CRPNPHVTPE PPCSSYQFQC ANEKCIYTSY
RCNGIDDCGD NSDEDDELCG QQIIYFKGGT CRSYQFQCNN GKCIYTSWKC DGDDDCGDNS
DEAGCPSTRP CSSYNFQCDN GQCIPKSWVC DTDNDCGDAS DEKDCELFDL KTCSSTQFTC
SSHLCISQYL VCNGFDDCPD GIDENDCPDV TCNPQYSFAC ADKKQCVSKT YKCDGHPDCR
DGSDEQGCPS KPPGYCESNE FQCQTSGMCI PSGWFCDARV DCDDGSDEPP TCPDTTCRSY
QFKCKNRVCI YNSYVCNGDN DCGDNSDEED CPTPPPTLPP PPCGTMDFEC PGTKKCISYN
KVCDGVEDCS FGTDEDTFCD ADLCSGFGCT DQCVNLPTGP LCWCDGSGYE LLNDSKTCAD
IDECARRYCS QACDNTEGSF YCKCDSGYQL DTDGRTCKVT SKLFCKVSKP YGRPLTPFVG
DRNSFLIHIR NLLGNDFDWA TRKIYYADTY YGNLYKAFLN GTMREIVFSS GTSITENIAV
DWVARNLYWC DYDLGTIEVA RIDGTHRAIL HAMNVTNPRG LALDPRDGYH YLFWTDWGQN
PRIERCDMDG NHRKSIITDR LFWPNGLTID YPNTMVYLDA KLDFIHRCGY DGQDRTEVLA
GTNFIRHPHS LTILEDYLYW TDRETYSVSR CNKWDGSKNQ TKVMTGLYYP TDLHAFHPVR
QPAGTNYCEG NPCSHICLLG NFRPRYYTCA CPVGSSLTDT HTCTPNQDDF ILVSTPGRIF
GIALDPEDQE SDKMIPVTNI VNGMDVEHDD SQGWVYWVDT RYKTIERIHV TGTNKSTFAY
GNLLGLSELA FDWVSRNMYY TNPDAKHIEV IRVDPGNNRQ YYRRTIIGNI GNETGVANPI
GLAVDPQNGK LYWSDQGGDG IPPKISRCNM DGSYIENIIT TSVNNIQHIA LDYSGGRIFW
AEQNSGSIMS ATTDGTDIRT IVDNVIRPMG LTVIGDYIYY SDLSLQLIER ADKTNGNNQQ
ILRSDVEDVT SLKIFNRPLS LANDCSKTIN GGCQQLCFVV GGSRRCSCST GFTLNGDGVT
CSSSDSFALV SLGNNLRGFN LDGASHVDAM PPMFSSYWNS SFVGVDMKQQ KIMWSSYRRG
GSTSGGYLGY LFNVVYAADR DNGYARQVVI GGIGSRGITG FAYDWVSQNI FFLNGFTRET
YLEVGTYNRR YRLILIKIVD DMPVAIAINP LKRLLYWADY GQVPKIESAY MDGTNRTILA
TSGLTQPRSI VIDYSTHDVY WCDEQSSTIE KMSWDGSNRV TIRSGRNYPS PRGVAVYQDY
IYWVDPTWKS LFRASTDPSN QDDPEKLRDG LENPQDVAIY DQSIQPDDPS NNPCANNNGG
CSQLCIALPD NSRVCKCAFG KIGNDGTSCN DAEDYVVFTT TRDISGFHVD PDDHSLIFPT
VTASYPIAVA HDLQDNRAYF ATRQGSYSRI GYIDLNSNPS YPKYVVTSGL RGPEGTCLDF
DWVHRKLYYT DNSLKIIGSV SPDGSNMTTV VSGLNLPRGI AVDPCRGYIY WTDWGTHTIE
RSTLVGNGRT VIVSEDLLWP NGVTIDFDED KLYWVDAEPK ERVERSNMDG TERELIIPSL
DHPFAIAILD QFVYWTDWST RGVYRWIYYE ILMIKHLYGF LLSIVHTASP LHRFNGGCSD
ICSIGPSNTA ECSCPIDDGK KYYLANNGKD CIEDTGQDRC NANQYTCSNG ICRPLSWVCD
GYTDCSDGAD EAERTCADHT CESHRHRCPN GRCIPISFVC DFDDDCGDGS DEQGCPTPTC
ASDEFECLYG RCLSISQVCN GYDNCRDGVV SDEKDCNHTT CRPGYHKCTN TNVCIYGGWL
CDGDNDCGDN SDEAPVFCAG KTCRSGQFQC DNVYQCIPLT WYCDDYNDCD DGSDEPTQCT
HPDRTCPQGA FTCDNGRCIN IDWVCNGVND CNDNSDEDER QDCGSRTCQS TEFTCEGNPP
GHSRCISRLF VCDGDIDCED GADELQPECP PTICNENQFN CTNGLCIPKY YVCDHDNDCG
DYSDEYGDCV YQTCSSYQFT CENGKCIPKS WTCDGRNDCT DNSDEVSCPT GPPTCGPDMF
MCKNGQCIDM GVVCDRNPDC SDRSDEERCG LNECATIASN QCAQLCVDTL TSYYCDCNPG
FRLLADGKAC EDINECIETP WVCSQLCDNI EGSYYCKCGS GYLREPDGVT CRQNSGIEPY
ILFSNRYYIR KIAVDGSDYE LVKGLDTVVA LDYDYQGQRM YWTDVTAKQI GSMKFDGTDK
KTLFHREVPD GEGLAVEWVT GKLYWLDATL RALHVSELNG TSKLTLMKGC IDVNRTYCFH
SPRALALHPK RSLLFWTDLG LKPYIAKAYL NGDNAQTVIT TVVGWPSALT IDYVTERIYW
GDAHLNAIQF SDMDGNNRHR LYLNGLNQPM AFAITFFESY IYWTDYSTYS MYKAHGLDGS
NLQRLVNSTH RQYDLHVVHP YRQDNRLTNP CEMNNGDCSH LCLMAMDGNK ECKCPDNFVS
VSVGITGTRC FPACTSAQYR CDSTEKCIPI YWKCDGVEDC PDGSDEPDTC PPRSCPIGYF
QCVDYGCVKP EYMCDGDNDC DDGSDEVNCD DYPCLDTQFK CGNGKCLSNS RVCNGFDECG
DNSDEDADMC AQHTCPVGHF QCDNGRCIPS NWWCDVDNDC GDGSDEPVAV CASDQHVCRP
ELDFACKTNY RCVPKYSMCN GIDDCYDNSD EEQCSQMTCD PNNDYQCPNF RCIPLRWRCD
DYNDCGDNSD EVGCAPRQCS ESEFRCDNLQ CIPGDWVCDQ YDNCGDGSDE RGCTAATCST
GFFECTSGHC VPSSVVCDGD RDCLDASDEA ACVPKFPGGR YCPNNRFQCD NHVCVNLNFR
CDGQNDCGDE SDEYPSVCES IDCVSPKWRC EKTRLCIFEN QKCDGKDDCK DGTDETIEMC
HPTTVAPTCT YVQFKCFNGK CVSELVVCND VDDCGDQTDE SGCHKGDTTH TCADKPCEQV
CTTIPSFGDI PGYYLCSCND GFTVSGFNDN THSCDDINEC FESWSTCSQI CRNTKGSYQC
ECGDGYVLSG TTECSAEGFS MMLIADEQDV ITYDVLNDKE AKLVQRQLRM GAMDYAYLGG
NQSVLIWTDT ATHTVKPKIV RTMMPYMDGS TNNFGISQDL AVPGLTKPNG IAVDWVTQNI
YWTDETAGSI TVSLLDGRYP KTLIDRIDTP RAIVVNPKSS YMFWTTLGLT PAIYRSHMDG
GSIIQLDDVV VGYPTGLAID YQHGGRLYIC DEQADRIIAV SQHGHNQVNI ARGAGNPISV
EVFENTVYWT TSDKSLYRNE KFGRGVKKLL RRGLKSASDI KIYHPSRYES GMAQRCKADS
CSHLCLLSPG SYTCACPDGS SFFPGSARQC DASYVAPLPQ LSVCQCRNGA TCTYDENSMP
VCLCASGYFG VNCENGASVP LPSLADGGII AAVVVIMVVI GVAGFFYFRK KNS
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