ID H2YAY2_CIOSA Unreviewed; 1870 AA.
AC H2YAY2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000002480.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000002480.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR Ensembl; ENSCSAVT00000002521.1; ENSCSAVP00000002480.1; ENSCSAVG00000001468.1.
DR GeneTree; ENSGT00940000165769; -.
DR HOGENOM; CLU_000423_1_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 17.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 20.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 19.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 21.
DR SMART; SM00135; LY; 11.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 21.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 9.
DR PROSITE; PS50068; LDLRA_2; 21.
DR PROSITE; PS51120; LDLRB; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 17..59
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 60..102
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 656..671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 771..813
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 865..908
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 909..951
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1538..1552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 1637..1678
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 222..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 229..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 263..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 270..288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 282..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 302..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 309..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 427..439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 434..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 515..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 522..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 555..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 562..580
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 574..589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 596..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 603..621
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 615..630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1088..1100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1095..1113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1107..1122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1127..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1134..1152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1166..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1173..1191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1217..1232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1245..1263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1257..1272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1277..1289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1284..1302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1296..1311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1316..1328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1323..1341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1335..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1360..1372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1367..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1470..1482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1477..1495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1489..1504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1870 AA; 208207 MW; 52EF166CA9D19830 CRC64;
VSGLNLPRGI AVDPCRGYIY WTDWGTHTIE RSTLVGNGRT VIVSEDLLWP NGVTIDFDED
KLYWVDAEPK ERVERSNMDG TERELIIPSL DHPFAIAILD QFVYWTDWST RGVYRAEKQT
GGFVTQMRTQ LRQHTYGHSW LFHTITRRVF NGGCSDICSI GPSNTAECSC PIDDGKKYYL
ANNGKDCIED SSIILKFKKS RLTFANTKSC RFLKIELSFF QCNANQYTCS NGICRPLSWV
CDGYTDCSDG ADEAERTCAD HTCESHRHRC PNGRCIPISF VCDFDDDCGD GSDEQGCPTP
TCASDEFECL YGRCLSISQV CNGYDNCRDG VVSDEKDCNH TTCRPGYHKC TNTNVCIYGG
WLCDGDNDCG DNSDEAPVFS GKTCRSGQFQ CDNVYQCIPL TWYCDDYNDC DDGSDEPTQC
THPDRTCPQG AFTCDNGRCI NIDWVCNGVN DCNDNSDEDE RQDCGSRTCQ STEFTCEGNP
PGHSRCISRL FVCDGDIDCE DGADELQPEC PPTICNENQF NCTNGLCIPK YYVCDHDNDC
GDYSDEYGDC VYQTCSSYQF TCENGKCIPK SWTCDGRNDC TDNSDEVSCP TGPPTCGPDM
FMCKNGQCID MGVVCDRNPD CSDRSDEERC GLNECATIAS NQCAQLCVDT LTSYYCDCNP
GFRLLADGKA CEDINECIET PWVCSQLCDN IEGSYYCKCG SGYLREPDGV TCRQNSGIEP
YILFSNRYYI RKIAVDGSDY ELVTQGLGYS GFIQSSCTTL KGTNTSTHRG QRMYWTDVTA
KQIGSMKFDG TDKKTLFHRE VPDGEGLAVE WVTGKLYWLD ATLRALHVSE LNGTSKLTLM
KGCIDVNRTY CFHSPRALAL HPKRSLLFWT DLGLKPYIAK AYLNGDNAQT VITTVVGWPS
ALTIDYVTER IYWGDAHLNA IQFSDMDGNN RHRLYLNGLN QPMAFAITFF ESYIYWTDYS
TYSMYKAHGL DGSNLQRLVN STHRQYDLHV VHPYRQDNRL TNPCEMNNGD CSHLCLMAMD
GNKECKCPDN FVSVSVGITG TRCFPACTSA QYRCDSTEKC IPIYWKCDGV EDCPDGSDEP
DTCPPRSCPI GYFQCVDYGC VKPEYMCDGD NDCDDGSDEV NCDDYPCLDT QFKCGNGKCL
SNSRVCNGFD ECGDNSDEDA DIQHTCPVGH FQCDNGRCIP SNWWCDVDND CGDGSDEPKN
CNLTDFPNRC VPKYSMCNGI DDCYDNSDEE QCSQMTCDPN NDYQCPNFRC IPLRWRCDDY
NDCGDNSDEV GCAPRQCSES EFRCDNLQCI PGDWVCDQYD NCGDGSDERG CTAATCSTGF
FECTSGHCVP SSVVCDGDRD CLDASDEAAC VPKFPGGRYC PNNRFQCDNH VCVNLNFRCD
GQNDCGDESD EYPSVCGEIT LMALLSFLCI LLYYINCSAE SIDCVSPKWR CEKTRLCIFE
NQKCDGKDDC KDGTDETIEM CHPTTVAPTC TAGQYKCFNG KCVSELVVCN DVDDCGDQTD
ESGCRDDNTH SCDDINECFE SWSTCSQICR NTKGSYQCEC GDGYVLSGTT ECSAEGAKEA
KLVQRQLRMG AMDYAYLGGN QSVLIWTDTA THTVKPKIVR TMMPYMDGST NNFGISQDLA
VPGLTKPNGI AVDWVTQNIY WTDETAGSIT VSLLDGRYPK TLIDRIDTPR AIVVNPKSSY
MFWTTLGLTP AIYRSHMDGG SIIQLDDVVV GYPTGLAIDY QHGGRLYICD EQADRIIAVS
QHGHNQVNIA RGNPISVEVF ENTVYWTTSD KSLYRNEKFG RGVKKLLRRG LKSASDIKIY
HPSRYESGSG DCYCDLYSCS HLCLLSPGSY TCACPDGSSF FPGSARQCDA SYVAPLPQLS
VCQCRNGATC
//
