ID H2YDB5_CIOSA Unreviewed; 1008 AA.
AC H2YDB5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000003313.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000003313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H2YDB5; -.
DR STRING; 51511.ENSCSAVP00000003313; -.
DR Ensembl; ENSCSAVT00000003364.1; ENSCSAVP00000003313.1; ENSCSAVG00000001977.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160615; -.
DR InParanoid; H2YDB5; -.
DR OMA; TCPGDYT; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 27.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 20.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00181; EGF; 27.
DR SMART; SM00179; EGF_CA; 21.
DR SUPFAM; SSF57196; EGF/Laminin; 27.
DR PROSITE; PS00022; EGF_1; 17.
DR PROSITE; PS01186; EGF_2; 12.
DR PROSITE; PS50026; EGF_3; 26.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 1..26
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 29..66
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 67..102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 103..136
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 139..175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 177..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 217..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 252..288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 291..327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 363..396
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 399..435
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..474
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 477..513
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 515..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 625..657
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 660..696
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 697..732
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 735..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 773..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 810..844
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 846..883
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 893..929
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 933..965
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 968..1004
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 56..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 92..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 165..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 278..287
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 464..473
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 503..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 614..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 686..695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 722..731
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 761..770
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 799..808
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 813..823
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 834..843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 873..882
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 919..928
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 937..947
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 994..1003
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1008 AA; 105918 MW; F404CE9417AC2A22 CRC64;
CLHGGTCTLL PDLSYTCLCT NYYSGLNCEK KVCDPNPCLN GGVCLNKGGY TFSCLCPVGY
NGTTCDISVC DSMPCKNGGT CTPTATSYTC TCPSKYTGMH CKTDLCRPSK CMNGGICAYA
PGNTFICNCL SGYSGNLCET NLCTNQTCYN GGTCQPTQTS YTCLCTNDYH GVRCENPPDA
CHPNPCLNSG VCSLNSAGFT CACVVGYNGT TCENGVYAYV CLSSPCLNGG TCQYNRTKLC
ECTQGYSGDS CELDLCASNP CQNGGTCTFD GVNYACGCVA GYSGVNCQTG MTDTCLPTPC
LNHGTCIHTT TNYNCSCLTG YTGTNCEIYP CTTLQCNNGG SCYKNNGVEK CACLPGFSGN
TCQIDACTSN PCENGGTCTV NGTSYTCQCA SGYYGYNCLS DPCTAGPCVN GGTCQVQLPS
HQCTCPVGFS GKNCELGIVY ACGSNPCNNG GICQVVGTTF QCICSTGYTG FTCFQTSIDV
CSSSPCSNGA TCLADGTSYT CACKSGSTGP LCKTLVDSCT NNKCKNGAVC TVTGATTYYC
QCVFGFYGDK CQYNSCSVKP CKNGGTCKTV GTDYTCKCKT GYYGTNCEND PCTVKPCLND
GKCKVSGSSY TCTCMDGYYG TTCQHDPCTI APCQNNGVCF VSGAHYYCQC QQGFHGTNCT
QDMCSLKPCL NNGTCSLEGS GYKCTCPGDY TGLLCQSDPC ASKPCANDGE CLVVNTTYSC
KCKEGYYGRD CKSGGWYPCA VAPCQNNGVC FVSGAHYYCQ CQQGFHGTNC TQGNNMCSLK
PCLNNGTCSL EGSGYKCTCP GDYTGLLCQS DPCTSQPCVH GVCVVAAHQY FCHCNDGYYG
VNCTTGAWKC SPNPCYNGGV CSVQATGRVL CKCQRFHSGQ YCETPNLTDQ IIFTDPCTTQ
PCKNGGVCSV VGGSFQCQCK GGYTGDLCQI PLYVDPCTSQ PCEHGICIVS GAEYYCQCFD
GYHGVNCSYD ACSTSPCTNN GTCIVVGSDH FCLCLPGYQG KICNISEF
//
