ID H2YFC8_CIOSA Unreviewed; 7069 AA.
AC H2YFC8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000004026.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000004026.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR Ensembl; ENSCSAVT00000004086.1; ENSCSAVP00000004026.1; ENSCSAVG00000002380.1.
DR GeneTree; ENSGT01100000263532; -.
DR HOGENOM; CLU_223080_0_0_1; -.
DR OMA; AQGQDRK; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 39.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05748; Ig_Titin_like; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 67.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 39.
DR Pfam; PF07679; I-set; 27.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 40.
DR SMART; SM00409; IG; 27.
DR SMART; SM00408; IGc2; 24.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 23.
DR SUPFAM; SSF48726; Immunoglobulin; 28.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 39.
DR PROSITE; PS50835; IG_LIKE; 23.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..60
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 155..242
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 433..529
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 535..632
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 626..725
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 729..826
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 832..926
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1025..1128
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1134..1232
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1236..1322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1333..1422
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1432..1527
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1531..1620
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1627..1720
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1726..1820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1824..1918
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1922..2018
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2024..2119
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2126..2215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2222..2325
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2329..2424
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2428..2521
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2528..2622
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2629..2725
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2827..2920
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2926..3021
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3024..3117
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3124..3221
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3224..3320
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3324..3411
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3423..3516
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3522..3618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3622..3709
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3721..3814
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3820..3915
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3909..4007
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4014..4108
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4110..4203
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4207..4297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4306..4399
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4405..4499
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4503..4592
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4601..4695
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4701..4796
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4802..4918
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4918..5009
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5016..5109
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5115..5210
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5217..5306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5314..5407
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5413..5509
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5515..5615
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5619..5708
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5812..5906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5909..6008
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6016..6106
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6124..6201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6210..6303
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 6336..6591
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 6666..6757
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6794..6885
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6969..7057
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 5196..5217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 6365
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 7069 AA; 780163 MW; AA3E9258F37B54D9 CRC64;
SRPNAEVRWF KGRAIIRDSE KYEIRAEGCK RTLVVLQCSF DDEKKYTCDA DDARTSAKLT
VQARAIKFLK PLEQKIRVTE REEVVFEIEL SHTDVEVIWY KNGAKMARTK NVELYTDGAV
HKMVIHRANM EDYGVEVVAQ AEEETSMTTL FIDEPPVKFP RTLSDKTCEE MDRVVLECEV
SRANANVVWL KNNEAIEASD KYVNKQQSTG KGRSLLIKDI KKSDKGKYIC VCGDSKSTAE
LAVKDGVKFT KPLSDVNVLE KDGAVLQCEI SDPDVKVRWY KDGLPITNSD RVTIEANGKI
HSVSLPWTLC SDTGSYQVVA EFAKSDAKLT VEGKTISFVK RLWDHDFEPT KTCVLECKLN
KPFANVVWTV DARVIKTDRR HTIKVVIINH DNTKLRFRKP TINNSGRYKI VAKNKYGEDS
AYITVTVIDR PQPPVCLTVS NITAQSAVLT WEEPEEDGGS PIVSFLVEKR DVKRKMWQSV
SDEVEDTEIT VSVQKLVEGN TYSFRVSCEN KVGLSQPAEI SNPVLAKSQF VLPSSPLNLR
YENCTKSSIE LCWETPMSDG GAPITGYVIE VCDKSEDEGL WTAEGFIDKV TGLHFVVCGL
DESHEYSYRI RAVNKIGEGK PSDATPFVLA KDETNGVSVK AGSMIEIPAI VAGRPFPTAR
WSRDEVILFP DQRTVEEDKD RSSTLTTSDG ITKYRVPGAK RSDKGTYLIT AENDQGKATA
SVVVNVLDVP SPCKGPWSFE DGTNEAVTLR WKIPEDDGGS DIINYVVDMK ESNKKVWTKL
STTLQSTKYR ATKLVENKEY IFRVCAENKM GKSPWIEAAP YVAKLPFDPP AAPEKPVVVD
VTRKSMTVKW AEPYDGGSTI IGYCLERKDT TASRWSRASR EMIRAVEYVV TTGLTDGLTY
QFRVAAENEA GQSKFSQPSD YEVCEDPVFA PSSPRKPRVE DTTSSSITLA WDRPEGDVTG
RPYPDITWSK DGEEISDRVE VKKTDIGSQA LVKRSVRSDW GEYKITAKNS SGTKSATCLV
VVQDVPGAIK ELKIGAVSRN CITLKWHAPE DNGGMPVKKY HLEKRDIDSP RWKKVSRAPI
TKPPLVNCSY KVLKLVEGLD YKFRASAVNK AGIGPVSEES DPVKSQDPTF VPGAPEQLEI
SDITATTLSL SWTAPQNNGG ASILGYIVEY QDQVKCNWTK LLVDEKELIL ETCATIPNLT
TRLRYQFRVS AINAVGHGEP CEATSFIEIK DQIEAPSITL DVGIQNTLEV RAGASIKLVA
TIKARPTPET RWEKDEKLPL PGTAVIKNTD ASSEVTITDC GRDDSGRYTI VSKNIGGTRT
ASCKVLVKDT PGAPLPLVVS NVTKRGAKLS WKTPCNDGGS KIQTYIVEKR RADGRGWVKL
DSSYRVRGLR EGQEYMFRVA AVNAAGQSEF SAPSIETMIP ITARDPVSEP GRTEELQVTD
VTRSTVSLAW KPPKSDGGLP ISEYLVEKRL VGQERQLLAT DKMVRDTEVT LEGFSEGDNY
EFRVIAKNER GTGPPSFPTK PVVCRNTIEP PTLKIVAREK MIVRVGEPYR ILVKISGKPA
PTVTWEQDGK LVQTDSRFQI KTTPTTSALE VHKGERKDSG LYKVTVQNDG GQRDGNIILA
VVNKPTPPRD LDVKEVTHEH VLLTWEAPED DGGSELLNYV IEKRDISRMM WTTVNSTSLK
TEFRISKLSE GSEYVFRVMA ENNQGCSNPA ETQGVVVKDR YRVPDAPDAL TIKEVHKDSV
SLSWNKPYDG GKAIFNYVVE KREIKSERWV RVTKELINES RYTVTGLFES NEYEFRVAAE
NSIGIGAKPD HTVPVAPRQK LSSPSVEIDV KTLEGLTVRA GSTLRIPATI HGIPVPTAQW
STADGNVVVT DDRITCDTDS NSNETRLTIS NATRADCGHY VVTATNKTGS DSASAQVNVL
DKPAACVGPL KIISLKQRCT VAWEPPADNG GCEITNYMLE KCETSRMVWS VVTASVTACA
YPVPRLLEGN EYIFRVKAEN KMGLGPAIES SPVVAKSPYD KPGAPSAPEI TKIGNGTATI
AWKAPDKDGG RDISGYFVEK REKKGVRWSP CNTKSIMDRR LNVLGLSIGY DYQFRVAAEN
EMGVGEPSEP SKMVTIKEPT EILEEPEIDL DVDMRKNIEI KAGSTLRLLA DVKGRPKPTI
KWTKFGATLS RRADVDVTDL KTTLVVPETT RDDSGKYTLT ASNARGSKSA NINVKVLDTP
GQVSNIVVKD IKATSAQISW TPPDMDGGSE ITNYVVELKE SDKKTWSVAT TECPKTAFRV
TKLVEGKDYY FRIKAENKYG FRVQACNTAG AGAFCKPTDP QVARDQCDAP GKPEVVDVTD
TTVELGWAPP RSDGGLKIAG YIIEKQKLPN EKWVRHITTR GPEASVVLVN LEEGERYCFR
VLAKTAVVVS KPSEPTEAIL VRQAIAAPSI TLDASCRELL VVRAGQDIVI EATIVGKPKP
TAMWTRGEDQ IKSTSDGSVT AETLLNQSRV IIRSCKRSDA GNYVLTLENT SGKTSATAKV
RVLDVPGMPE GPAKFSNVLS DRLKLIWNRP LEDGGAAITN YVIERRETSR PTWAMVSGSA
QGTELAVQKL IQNHEYEFRI SAENKYGIGQ SLVTEPIIVK NPFSYPPAPP AFPKVLDTTR
STVEIAWGKP AYDGDSPITG YFVEMANPES PDNFERVATT HITKYTMTGL SDGREYRFRI
KAVNAIGESE PSEVPETNTV TIRELLIAPN VDTSKLFNNT VSEKVGTNIH IRVPYTGTPT
PVAHFIRNGE PIKQTSRVNS DTSNGIAKLN IGEVTRKDAG EYELVVKNAV GTKTATLRVV
VMEKPAPPTG PMEIKDVSAE SITVAWGQPE EDGGTPVTHY TLEKLDCNIG WTEVSGFVVR
TSQKITRLTT GQEYIFRVRA ANKFGLSEPL DSAPVMARHP FNKPGTPSAP QVVSVTNDSV
VITWQEPTND GGSAILGYHI ERKDRNSIMW TKANSYIVRD STFKCGNLSQ GLSYEFRVTA
ENLAGFGKPS DSTGSVTARD EVEPASVDVD AQYRDVVCVK AGEAFTLKTY VSGKPVPTIS
WEKDGNEFES GPRVSILTTE TTSNVTVKDA HRADNAGNYQ LVLENSIGSK TIPVSVRVLD
KPGPPKGPVE FSVATTRETM TIKWEVPMND GGSKILGYHV EKKDRNSILW IKCSKTLVSG
TDYKITNLQE SLEYEFRVYA ENAAGFGKTS KSSDSAIARD AVDPPRDVEV VGITRHSAHI
QWKNPEYDGG YKVTGYIIER MEVSVGRWLK CNFSNVSVTN FNIEGLTEGL KYNFRVFAKN
AAGAVSIPAM TILPVLVKDD LQPPTIDMDA RFAELVTVRA GRTIKIEAGI RGKPTPIITW
KKDEQEFKLS GRISVKNTDV STCLEITDAD RDDTAAYSLA VQNFAGSRSL SIQVKVLDKP
GRPTGPITIS GTTAEKCTIS WRAPERDGGA PIINYVVEKR ETSHLAWVLV NPSVEGTTCK
ISKLLADNEY IFRVRAENKY GVGDALESVE IIAKNPFTTP SAPQSLEPTG VTRTSVDLIW
RKPENDGGAK VSGYVVERRE LPNGRWLKCN FSNLIDCKYT VTGLTEDASY EFQIIAKNTS
GSISAPSEPS EKVTCKDSFT PPRLDLNGNL KDTVVVKAGE TITLSASIFG KPVPNATWTR
NNVELDNTPR TEIMDTGSTA SLSIKDSTRD DSGDYVLHLK NTAGSRAISI TVKVLDRPGQ
PIGPLTISEV TSERCRLAWR APENNGGAPV THYNIEKRET SRLTWTLVES GIEGVTTKVH
RLLKGNEYIF RVIAVNKYGR GVPLESVPVI AKNPFSVPAA PGKPQVSTVM KNSAVLTWTR
PTSDGGSDIS GYHIERKERN SLRWTRAVRR SVPSLHHKVT GLSEGSEYEF RVSAENAAGI
GPPSECSTPA LCKEPCQKYS ADGDLRKNLT VKSGTPIKIV VPIRGRPVPS VRWSKEGAPS
VGERTQIETT ETGTTLLIPE SSRSDSGKYT LTLDNTSGST SASCSVKVLD TPGPCQNISV
KDISKDYATA TWEPPANDGG SNITNYIVEK KETGRKAWST ITTGCQRNHI KINLSEGLTY
LFRVMAENEN GIGVPVETST PVKATEVPGS PDRLEVVDVT KSSVALQWRK PDIDGGSKIL
GYVIESLEKD QNKWMKRITV KEPQASITNL KEGKQYAFRV IALNKVGASD PREASSLVLI
RDTFIAPSLD LSQLPHSVAH VKAGDNLDIS VPYVGKPKPS IKWVKDNATI RITKRVDTGT
EDDGIARLKI KEITQDDAGI YELHAENQGG KRCAKISVIV LDKPGAVEDL QTSNVTECSV
TLSWKAPAFD GGSAISSYVV DLRTSEEPEW RMVSSAIVRT TFKCTKLNLG KEYTFRIRGM
NRFGLGPATC TEAVTIQLSY KVPGAPASCT VSYACKDSIV VNWQEPVKDG GSQITGYHLE
VKDRNSILWK KANRVVIRST HFRVLGLQEG LEYEYRVSAE NAAGIGKPSR PSEAAFAHDF
RPPRINLDAH LLDEVTVTAG STLRLHAGIS GKPEPAITWS NNGNDIREDL RHVLHTTIDH
CSILIKDCSK SDSGVFTINA KNACGEKSAN VKVLVLDKPG PPTGPIKFSR VTDSRVTCSW
EPPMQDGGSK IINYIISKRE TSRLAWSVVS EKEELCTLTV QRLIKNNEYQ FRIQAVNKFG
VGEPLDSEPV VAKNNFTEPS APGQPEINNV CSSGCTVMWS RPESDGGADI DGYIVERRER
KSARWIKCNK KIVRDLRFKL SNLSENNEYE FRVAAENAAG IGAYSHISLP VVMRDPIDLP
GPPSSPRVRD TTRNSVMLSW GHPAYNGGSD VIGYMLESKI GEADDLQQQE TDETLSSIAD
NKEWKLVQSN ILGTKYTIEK LDHDTLYRFR VSAINKGGVG EPAAIVGAIK PVDRLEPPEY
DLDASLRKTM LVRAGNTVNI SIAVKGRPTP NVTWTKDNLN VTKNPRVHVD NVDGKTILVI
QDCTRDDTGK YALALENASG VARTFVSIRV LDTPGQPGLL NFPDITANSI ALKWSPPENN
GGSDITNYII EKKETSSDTW SSVNANCSRT TVKAIKLNQN SEYVFRIAAE NKYGLGEFTE
SQEVVAKHPF RTPTVPPQPE VVEISADVMT VVWKECHSDG GSQITGYHIE KKERNAILWT
KANLATLRSR EFKATGLTEG LEYQFRVYAE NMAGKSAPSE ASKPERAHNV VSPPTCPDWT
DITRDSVTLA GSPIEISIPI VGKPQPPNVF WSKGETDLED GEKTTILSAG KSTALIIKDI
SREDSAKYTL LLRNECGEKR TSINVKVLDK PGRPKGPITF SRVTAEKCNL SWERPEEDGG
ANVTHYVVEK RETSRVSWIA VHEMLEQTSC TVPNLIVNNE YIFRISAVNK YGQGQALESE
PLVAKNQFVT PDSPGQPEIA SVTRDSITVT WTRPINDGGS DIKSYIIEKR DKQGYIWIRC
NKNQDVTDLR YKACGLRNKA LVEFRVAAEN AAGVGKFSEA SAFGCVQDPV FPPAAPVHLK
VTDSTRSSVS LSWAAPLFDG GSPVDGYIIE FSECKADSED RWQKTHKSNY IQSTEFIATG
LKHGLEYKFR VFAVNINGTS EEPATLSETV FAKEILEEPE LELDDTFRKT VNVHAGKPLR
LCVFVKGRPA PSVTWTKAPN GEELTSRAFI ETHEAANSLE IEKVDRHDAG KYTVSIENAS
GRKETTINVR VYDTPVLQSF TEPIVVRKGG VICLKVPFKC RPSPQASWKK ISGPEVDLNV
RAMIALHTDS AELVIKGVDR RDAGEYEVTL SNKLGKISVS IRVQVIGKPD APEGPLQFGD
IQATSVNVVW KPITNDGGSE VTNYVVEKRE VGKTAWMTVD SKIRSTQCTV KGLTEGKEYF
FRVFAENAFG LGDALKCIES VTAKNPLFPP QPPQLVEINE VRKDKVFLAW TRSRDDGGSR
VTGYFVERKE AGSERWVRVN KILTKNLSFM IQGLVEDAEY QFRVVALNDV GEGEPTEICN
RTPRIRNDNK AAGEKPVIVE TLQTVMGVRE STATLTCTVS GRPMPDITWW YKGGREITGC
SQYKISEAKG NHYTLVVHNV TVDHEGPYTV RATNQAGSIS QTVEMTVQLP AKINLPKYMM
TEAIVCRVHE VVSIKVPIEG KPQPDITWSK AGKLVSADGH RQFITASSFT SMTITNADRR
DSGFYNVIVK NRFGTNQATI ELLVGDVPAK PESLKVSNVT RDSVDLTWKE PSDNGGKPVL
KYVLEKCTTS SDCWVKVSSS GTCKYTVCNL SGKTGYLFRV RAENEYGQSK PSSPSDAVTT
KEDRMMAANY DDMVDATEKF VASEARINKS NVMEKYQIME QLGRGTFGTV HRAREILTGK
TYAVKLCRFT DETEKVPINR EVSIMRKLQH PRVLQLHEVF DTKLETALVV QFVSGGDLLE
RIIATKFELT ENACAYIIKQ VLEALAYVHS QNVAHLDIKP ENILFITRKS KKIKLIDFGV
SRELKTGEGL RISFGTPDFC APEVVQNDTV GCATDMWSVG VLTYLMLTGL SPFQGENDND
TLRNVSDADY NFEHEAWRFI SDDALDFIDR LLLKDKRERM TADDALEHPW LRTLHPRIKV
QSVDMTPQLM PMYHVFVKEK DDAKISCRIR DADDNETIAC IYLNRHKKRG RKTAASEFSR
IVKCPPEFTL PLYNRTVYTG DTAIFTITVT VHPTPEISWY HKGQKIIINS EETHYAEIRE
KGLYTLEIRK SQLEDSGEVI VQAKNAYGED ECKAMLTVQG EDQPPPYNKL DSDDELLRPV
SYDTWKYSAA DYAPSFQLRM RSHVVPCGMS TKLSAFVRGR PEPQVTWYRN GTELASGGTK
YYVSNIGGVT TLEIVRCHEG DSGTYRCSAK NYLGENSDYS TLEVTGSEFE STASKRGVQD
FHMTMDMVDV RSTISRSRFD AISQATERDA SRSSTAFDDQ MSHASGFTPY VGSESRMGSM
TPSSAAGAPY FVIQPKSQYV LEGDSAYFAA QCDGKPSPKL TWYHDGRIIK DNEKYSLGAI
RGKRTLEIRD CQVIDVGNYV CIAESSKGSA TTEFTLDVTP RRRSASSAS
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