ID H2YJL7_CIOSA Unreviewed; 986 AA.
AC H2YJL7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Exportin-2 {ECO:0000256|ARBA:ARBA00018945};
DE AltName: Full=Chromosome segregation 1-like protein {ECO:0000256|ARBA:ARBA00032265};
DE AltName: Full=Importin-alpha re-exporter {ECO:0000256|ARBA:ARBA00030693};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005516.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000005516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the XPO2/CSE1 family.
CC {ECO:0000256|ARBA:ARBA00008669}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2YJL7; -.
DR STRING; 51511.ENSCSAVP00000005516; -.
DR Ensembl; ENSCSAVT00000005590.1; ENSCSAVP00000005516.1; ENSCSAVG00000003299.1.
DR eggNOG; KOG1992; Eukaryota.
DR GeneTree; ENSGT00550000074884; -.
DR HOGENOM; CLU_009614_0_0_1; -.
DR InParanoid; H2YJL7; -.
DR OMA; AENEFLM; -.
DR TreeFam; TF300473; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0007589; P:body fluid secretion; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 30..108
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 986 AA; 112079 MW; F3B94168E231BBC2 CRC64;
YSLNKKYMAD KVYKALESTL SPDEAVRKQA EKYLENVEAS AGYAVMLLKL VDDARQQQQS
TSMVPLAAAI TFKNFVKRNW RIVEDEPSKI SEEDRNTVKC TVVDLMLTSP KQYQKQLSEA
ISIIGREDFP EKWPSLLEDM NKKFQSGDFH IINGVLQTAH SLFKRYRHEF RSDKLWTEIK
HVLNTFAAPL TELFVNTLKL AEQNSSNVEN LRVLFSSLVL ITKVFYSLNY QDLPEYFEDN
METWMTHFHA LLTDKAILHT QDDEEAGLVE LLKSQICDNV ALYAQKYDEE FAKFLPQFVT
AVWNLLVNTG KEVKYDLLVS NAIGFLRSVC ERQQYKSLFE DEGILVSICE KVIVPNMEFR
TADEEQFEDN PEEYIRRDLE GSDVDTRRRA ACDLVKGLTK FFEAPVTRIF SQYVGSMLQQ
YASNPSTNWK SKDAAIYLVT SLAQKGSTAK HGTTQSNQLV NLEEFFNTHI LTDLNQENVN
SLPVLKSDSI RFVVTFRNQL GRPNLLLVFP HLVRLLLSTG HVVHTYAAHS VERILMIKDG
NSNSPLFRKE DILPHLESLL SNIFGAMGMV GSEENEYMMK ALLRVVSLAQ DSVLPYMPTL
VEGLTQKLVI VSKNPNKPHF NHYLFEVLSL CIRSTCSKDK SAVVGFEGAL FGIFTDILQR
DVTEFIPYVL LPPIVVHWCN LISTPVMSLL LELHEPPVPD TYMALFPHLL APVLWERPGN
IPPLVRLMQA FIEKGGNSIG ASDKFNNVLG VFQKLIASKS NDHYGFYLLN SMIEFMQPDL
LEPFMKQIFS LLFQRLMKSK TGKFVRGILV FFSLHIIQTS ADKFQQLIDS IQNRMFSMVL
EKLIISDTQK VSGAMERKIC SVGMTKLLTS CTALLDENYS HLWAPLLEAL IGLFELPQDD
SVADDEHFIE IEDTPGYQTA YSQLAFAGKR EHDPVKVENP KLFLAQQLSS LSKQMPGKVS
GMLGYLNPKA QEFLKGYVTA AQVTIS
//
