ID H2YJU8_CIOSA Unreviewed; 715 AA.
AC H2YJU8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005597.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000005597.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; H2YJU8; -.
DR Ensembl; ENSCSAVT00000005672.1; ENSCSAVP00000005597.1; ENSCSAVG00000003342.1.
DR GeneTree; ENSGT01090000259987; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF60; INTEGRIN BETA-PS; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF00362; Integrin_beta; 2.
DR PIRSF; PIRSF002512; Integrin_B; 3.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..388
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 569..644
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 668..714
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 82..88
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 136..198
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 386..390
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 408..448
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 413..422
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 424..439
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 454..459
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 456..489
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 461..474
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 476..481
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 495..500
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 497..534
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..520
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 540..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 547..561
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 569..578
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 575..639
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 715 AA; 79262 MW; 95118C7B6FCC4395 CRC64;
GDPLNIELSF KQAEDYPVDL YYLLDLSKSM ENDLNSLRAL GRELGMSMQN ITRDFRLGFG
SFIDKTVMPY ISTVPAKIKN PCSDKAPCVP TYSFHNDLPL TPEIEAFVTS VNNVTHSSNL
DNPEGGLDAM MQAIVCKVRL VLKNFALSPC FVQAPVYRFN INWRKDATHL LVYSTDASFH
YAGDGKLGGI VLPNDGRCYL NSKGHYYNAN YMVGFCYIFI AMILLHFVLI FAGLPINRAF
SEKNHIAQYS THICRNFECH TNIHSKYLVD LGFLQNLQKM IPKSVVGELS GDSSNIQLIQ
DAYNDTERIR WAPIHWVTGV ACHPCYDVGT DSLGHRGGIC LIQPFHSQVN FTFTLSTEKC
LTSPVQVIVS PYGYNEVVTI NVESLCDCQC EETEAPTNNC SGHGNYQCGS CVCESGFTGL
DCSCDQKDVL GIESYLANCT DPTTGVVCNR GGECQCGSCI CTQYANKKID GKYCECDNTS
CKRAGGKVCN GMGKCDCGDC ICEPGWKGKA CECTLEQALC YDHSDDALDS TKPCNGNGEC
ECGQCVCKLS QGGAKFRGQY CETKPLVVCD IHRDCIQCNG MAHWQLILSA RRSMTEDYQY
SGYSQECRFT DLSDDCTYQA NFEEIDGIIM VEVEPDKVCK TYANPVYIII GIIAAIVGIG
LAILLIWKLL TSIKDAREYK NFQKESQNPK WQGGENPIFK KATSTFKNPM YSAGK
//
