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Database: UniProt
Entry: H2YLU3_CIOSA
LinkDB: H2YLU3_CIOSA
Original site: H2YLU3_CIOSA 
ID   H2YLU3_CIOSA            Unreviewed;       620 AA.
AC   H2YLU3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000006295.1, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Proteomes:UP000007875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA   Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA   Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA   Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA   Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA   Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA   Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA   Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA   Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA   Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA   Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA   Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA   Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA   Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA   Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA   Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA   Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA   Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA   Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA   Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA   Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA   Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA   Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA   Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA   Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA   Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA   Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA   Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA   Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA   Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA   Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA   Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000006295.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC       {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR   AlphaFoldDB; H2YLU3; -.
DR   Ensembl; ENSCSAVT00000006374.1; ENSCSAVP00000006295.1; ENSCSAVG00000003771.1.
DR   GeneTree; ENSGT01080000257336; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd17336; MFS_SLCO_OATP; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004156; OATP.
DR   NCBIfam; TIGR00805; oat; 1.
DR   PANTHER; PTHR11388:SF157; KAZAL-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR   Pfam; PF03137; OATP; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU362056};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362056};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT   TRANSMEM        69..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        134..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        171..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        219..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        302..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        340..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        494..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        530..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        585..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   DOMAIN          417..469
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
SQ   SEQUENCE   620 AA;  68112 MW;  F2FA3B4C65FB971A CRC64;
     KIEKAMNLFE LLHQVLAGTY SRSVLSSIER RFELPSTISA VVSSSYQIGN LTVMALVSYL
     GSKVNRPRFL AAGSLLLFIG YILVVLPQFL GDLYVFADLS TTSTSNHSQT FTFAEITPHS
     TSCEMEEEKA NSNMYIFIIV GMMVCGIGGA PTQPLGLSYV DDHASEHNSA LYIGIITTIT
     LVGPALGYLM GSFCLKIWVD FGRVDLDSIT IDPKHQSWVG AWWLGFIVCI VVIAIASFPL
     WFFPKHLEKP EEKTKEDTKP EVTKLKKKMF YLQSQVNTFL PIFNETYSIN IIRLLKEKTF
     EYYICVLVIF TSIGFKIAGL GTFVVKYLEV AFGKSASQSS FLIGAINLPF LIIGTLLGSV
     IIKRWKLQKL GMVRLCICGF VLSFACMIPS FFIGCDTIAH AGLTVPYPTS AETEIADGVE
     STCNSMCHCD QNTYIPVCGP ANITYLSPCH AGCTDTSSES GKNEYTSCSC LGANGTSQSV
     TIGRCFVSNC EESVWGVIVS KSLSNFFSGM CITAIMILKM RTVLPQDKSF GIGIGLLVYR
     VLAAIPGPIA FGALIDSSCL FWSQNPCSNR SYCTVYDNHK YRRGFIGLVL IAQIASIVAA
     IVLHSLVVKE QGKYTFKQEH
//
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